HIV infection is an independent risk factor for stroke


A HIV infection is linked to a much increased risk of stroke, reports research conducted in North America, published in the electronic edition Journal of Acquired Immune Deficiency Syndromes.

The association between infection with the AIDS virus and stroke remained at a significant level after some studies and control options evil. Of factors related to HIV infection, viral load was found to be the most important factor of all.

The possibility of stroke increased parallel to viral load growth, suggesting that inadequate viral control and the inherent inflammatory and immunological sequelae may exacerbate the risk of vascular / cerebral risk.

Nowadays it is common knowledge that the Human Immunodeficiency Virus associated with this accentuation of risk of cardiovascular diseases. Despite this, trombogêncio effect of HIV is still not clear and everything is in the field of theories; however, the risk exists.

Was to get a better measure this link scientists from Boston outlined a study that compared the incidence rate of stroke in 4 308 2005 between PLWH and 2007 32 000 and seronegative individuals as a control group for the analysis.

There was a wide prevalence of risk factors for stroke in people with HIV, such as high blood pressure, diabetes, smoking unhappy, cardiomyopathies, left heart valve disease and heart failure.

132 stroke have been noted in people with HIV and not 782 in people carrying the virus. The index was 5.27 per thousand patients / year between seropositive and 3.75 every thousand patients / year in people who are not HIV-positive people.

Within this analysis the researchers, HIV infection showed to be linked to a gain of approximately 40% risk of stroke (HR = 1.40; 95% CI, 1.17-1.69, p <0.001).

Even taking into account that the traditional risk factors have mitigated this value, the risk of stroke remained remarkably high in people living with Human Immunodeficiency Virus (HIV) (HR = 1.21; 95% CI, 1.01-1.46, p = 0.046 ).

"Smoking and the Hyper Tension Arterial risk factors were more prevalent among people with HIV and significantly associated with stroke," the study authors emphasize "These factors may therefore be targets of interventions truly importantesjunto community seropositive.

This link between HIV infection and increased risk of stroke was more significant among women (HR = 2.16; 95% CI, 1.53-3.04, p <0.001) than in men (HR = 1.18; 95% CI, 0.95-1.47, p = 0.14).

In addition, the aggravated risk of stroke in persons serologically positive for virus was more restricted to younger people (the 18 49 years). As an example, HIV-positive in the age group between 18 29 years and people had a fourfold higher risk than those who do not carry the virus in the same age group used to control (ARR = 4.42; 95% CI, 1.56-11.09).

The authors of the research function of HIV as a risk factor for stroke may be more pronounced in younger people, before the common risk factors related to age began to play an important role in this context, analyze.

The analysis of factors specifically related to HIV infection and its actual weight in the risk of stroke, this demonstrated that viral load amplified the hazard of stroke (p = 0.001).

Moreover hand, prolonged duration of antiretroviral therapy (famous cocktail) (p <0.001) and a lower viral load 400 copies / mL (p = 0.008) reduced risk that substantially.

Demonstrated thus a new finding: The risk of stroke is shown enlarged in people with HIV compared with patients in the control group, and that this risk remains, the relativist way, after entering the weight of the risk factors traditional, finalize the researchers.

The observed association between oo viruses and stroke should make the responsible and caregivers to see HIV as a plausible risk factor for, in a nutshell, a stroke (CVA), and further lower the limit of an intervention more aggressively, with the aim of minimizing the risk of vascular tripod system, coronary risk and risk of stroke, especially in women and young people - groups not usually typified for risk addressed in this study.


CF Chow et al. Comparison of ischemic stroke Incidence in HIV-infected and non-infected pacientes in the U.S. health care system. J Acquir Immune Defic Synr, onine edition. DOI: 10.1097 / QAI.0b013e31825c7f24, 2012.

Michael Carter

Traduçãopara the Portuguese of Portugal:

GAT - Portuguese Group of Activist Treatments on HIV / AIDS

Adaptation to Portuguese of Brazil: Claudio de Souza Santos

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