Jesús Damieta - 05 / 12 / 2014
According to a US study published in the edition of the magazine in October 30Clinical Infectious Diseasespersons with HIV have a greater risk of heart attacks and develop end-stage renal disease (in which the kidney is no longer able to meet the body's needs) and not defining cancers of AIDS, despite continued use of antiretroviral therapy. However, the average age at which they develop these diseases would not be significantly different from the average age of the general population.
Several observational studies have found that people with HIV suffer from diseases associated with aging (see Day News 29 / 09 / 2014) Such as heart, kidney or liver affections and cancers unrelated to AIDS more often than people not affected by the virus. To date unknown up, however, if this condition develops at an early age, which would suggest that HIV accelerates the aging process, which is the subject of debate.
A research team from the School of Public Health Johns Hopkins (Baltimore, USA) compared the risk of developing three diseases associated with aging - acute myocardial infarction (AMI), end stage renal disease and cancers unrelated to AIDS - and the ages at which is produced in people with and without HIV.
The researchers used data coming from the study of the Veterans Aging Cohort Study (whose acronym is VACS). Data were collected between April and December 2003 2010, a period in which antiretroviral therapy great effectiveness (TARGA) was widely extended.
Since the development of TARGA, longevity of people with HIV has increased dramatically, to the point thatthe average life expectancy of people with HIVAccording to a study of the American Collaboration AIDS Cohort in Research and Design (NA-ACCORD, the acronym in English)was only slightly lower than the general population. Other studies have also shown a lower risk of developing serious diseases not associated with AIDS after starting antiretroviral therapy in the Spanish context (see Day News 19 / 10 / 2012)
The analysis included data 98.687 cases almost exclusively of men, of which approximately one third were infected with HIV. In this period, there have been cases of AMI 689, 1.135 cases of ESRD and 4.179 diagnosis of non-defining cancers of AIDS.
Participants with HIV had a higher risk of developing the three diseases compared with those without HIV, after making the adjustment for possible confounding variables. However, not enjoyed significant differences between both groups in the Middle Ages to suffer an acute MI or not develop AIDS-defining cancers. People with HIV who was diagnosed ESRD were only 5 an average and a half months younger than those without the virus.The authors concluded that the risk of suffering the three diseases was higher in people with HIV, but the age at which they developed was similar in both groups.
The research team that conducted the study calls for caution, as the results should not be interpreted as the state of people with HIV is also healthy - since although not reveal premature aging, but reveals a greater risk of suffering related diseases with aging. In addition, these results should be analyzed in a broader research context in order to understand the mechanisms that really work in the aging process of those affected by the virus.
Translated and Revised by For Diana Margaret Sorgato.
Source: HivandHepatitis / Prepared (TWG-HIV).
Reference: KN Althoff, KA McGinnis, CM Wyatt AC Justice, et al. Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected vs. uninfected adults. Clinical Infectious Diseases. 30 October 2014 (Epub ahead of print).