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HIV infection is related to a higher prevalence of diseases associated with aging second Dutch study

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HIV infection is related to a higher prevalence of diseases associated with aging

We also observed a higher prevalence of traditional risk factors of these diseases in this population group

The sad drop of blood with yellow HIV virus, biohazard warning sAccording to a Dutch study, published in the electronic edition of the journal Clinical Infectious DiseasesThere seems to be a relationship between HIV infection and increased risk of suffering from various diseases associated with aging.

The research team compared the risk of suffering cardiovascular, renal and bone diseases among people with HIV of old age and a control group of seronegative persons with similar characteristics. The prevalence of these pathologies associated with aging was higher in the group of people with HIV, especially in the case of CVD and kidney. As might be expected, we found an association between the likelihood of developing these diseases and the presence of other risk factors more commonly referred to, but also associated the existence of HIV infection, and the immunosuppression period suffered and the presence of systemic inflammation.

Clexane

The inflammatory HIV framework resulted, for me, a vasculitis. Vasculitis increased my risk of developing blood clots in the bloodstream. On two occasions I had Pulmonary embolism thrombus deep, and I'm alive, is Grace of God, who considered that would not yet come 'my time'. Well safe than sorry and next January will do minor surgery, similar to an angiogram, to install a filter in a major vein that connects the lower limbs to the body. This unfortunately did not deliver me from the two injections that I take daily. ms, at least in theory, will be safer

The prevalence of comorbidity due to diseases associated with aging was significantly higher among those with HIV than those found in the control group. This phenomenon, also present in those cases of undetectable viral load, is compatible with the findings of previous research. Thus, a higher prevalence of geriatric syndromes with low CD4 counts was related months ago.

The improvements in the treatment and attention which did not prevent HIV infection in many cases, reach an advanced age. However, in these cases appears to be to produce an appearancesmoking yl sigaro of early age-related diseases. Are unknown the exact reasons why this occurs, but they include the classical risk factors (smoking, obesity, etc.), Side effects of antiretroviral therapy, inflammatory effects of HIV infection and the damage caused by the immunosuppression.

In 2010, a research team located in Amsterdam (The Netherlands), established a cohort to study the relationship between HIV and the diseases associated with aging. The present study compared the prevalence of diseases associated with aging among a group of people with HIV infection and a control group composed of seronegative individuals for a period of two years, adjusting the results of both groups by sex and age. Risk factors related to an increased risk of age-related comorbidity were also verified.

The study population included 540 people with HIV in a group and 524 people seronegative in the control group. The groups were adjusted for age, with the same average age (of 52 years). Most participants were men who had said sex practices with other men.

About a third of participants with HIV had been diagnosed with AIDS, but during the study the practical totality was consuming antiretroviral therapy and viral load was undetectable.

The prevalence of cardiovascular risk factors - smoking, high blood pressure, waist-chair index, physical inactivity - was significantly higher in the group with HIV than in the control group.

3D golden number 5 - isolated with clipping pathThe overall prevalence of age-related comorbidity was also significantly higher in the group of people with HIV than in the control group, with a mean prevalence per participant of 1,3 1,0 against (p <0,001). Also, in the first group the probability of having several age-related diseases was significantly higher (p = 0,009). This higher prevalence occurred for all age groups considered (50-55, 60-65, 65 largest). Moreover, the moment of appearance of each disease associated with aging people with HIV was approximately five years prior to observed among those seronegative.

Considering each comorbidity separately, the prevalence in the group of people with HIV was also significantly higher in all cases, especially in the case of hypertension (45 against 31%; p <0,001), myocardial infarction (4 against 2%; p <0,018 ), peripheral artery disease (3 against 1%; p <0,008) and renal dysfunction (4 against 2%; p <0,044).

It was also found between the traditional risk factors (age, smoking, family history and index waist-chair) with higher comorbidity.

HIV infection acted as a risk factor independently, increasing the risk of suffering diseases associated with aging in more than 50% (odds ratio [CP]: 1,58; confidence interval 95% [IC95%]: 1,23 - 2,03; p <0.001).

By explicitly noted risk factors in the group with HIV, there is a first time to a longer period of HIV infection (p <0,001), a longer period receiving antiretroviral treatment (p <0,001) and a longer period with a CD4 count below 200 cells / mm3 (p <0,001) increased the risk of diseases associated with aging. However, after the elimination of possible confounding factors, only found statistically significant time of immunosuppression.

There was also a relationship between the risk of age-associated diseases and inflammatory markers. HIV infection is associated with inflammation, immune system activation and coagulation disorders usually considered causative of much higher comorbidity in people with HIV infection and those that are not infected by the virus.

Weather in treatment in complete dose ritonavir (Norvir) met at the limit of statistical significance.

The authors concluded that the study results would support the hypothesis that links HIV infection with premature aging. It is questionable whether this is due to the way HIV acts as an added risk factor to traditional, increasing total comorbidity, or whether HIV acts directly on the very biology of aging.

Jesús Damieta - 29 / 09 / 2014

Translated Diana Margarita SorgatoOriginal in Spanish this link.

norvir

Many years ago when I lived in yet another city, I went through a tremendous financial difficulties and ended up having the electricity cut. I went there and religuei. He came and cut the top of the pole; I went up on the slab and religuei; they cut across the street where passing power lines and I did not risk. I went to the court of justice and got a lawyer, do not know how, and he filed an injunction because I would (not take) norvir and this remedy had to be (as has even) stored in the refrigerator. I spent hours there, desperado. Almost eight in the evening judge signed the injunction and ordered the bailiff in CPFL. They religaram the light and I was, unemployed, with months of back rent, the utility maintained by an injunction. Then came the blackout. They cut my light; Therefore, eight months later. Before paying the light I had to get diunheiro to have food to eat and God knows how much I have had to turn to it (!); at the time, one of the leading d Commission of Women Lawyer made a kitty and all OAB building in St. Paul has paid contributions and almost £ 1.000,00 in electricity bill was paid. This is one of the rare times I received fiduciary help anyone; I remember having sent an email to several "famous" and the father of a particular to the volate in formula one replied that if touched with my case and made a donation. US $ 100,00. Debts grew, the bank used some stratagem and justice (sic) led me to TV, the computer and stuff ... Not worth telling the rest! I remembered it to see the norvir box; damn memory. Know because I was unemployed? Simple, in 1996 I got to get my FGTS due to HIV infection (then we died like flies and it was almost an act compassional deliver a zombie its guarantee fund for, after all, it does not 'last long'. When I arrived in the city where I lived for three or four years, I got a job in a computer store, as 'técinico in hardware' - Today I know that at that time, I was exchanger parts. But well changed the parts. I worked two months without registering, after this time, they decided to register. I remember that there was much "zum zum-zum-'with the number of my NIT, they came to know me if it was the same. And I confirmed it was. In the records of the CEF included the code of my drawing of the guarantee fund and he indirectly infomava I drew the Fund due to AIDS d. A week later I was summarily dismissed and what I got in justice, now of money, would not yield or £ 250,00. PQP. The great thing was that they me "denounced in the city coo _aidético_ and all the gates in computer shops closed. I lived there a while nozzles. But in town with 300.000 people the hardest thing is to keep nozzles; course, there were more serious things, I can not even mention because they involve other people, but, in short, I was expelled from Piracicaba (to say all) because of the discrimination to people with HIV in the work market, which is something systemic. They dismiss ten people cutting title expenses only and solely to get rid of someone with AIDS. The thing is so serious that about 9 months ago I got a job in a large company here in São Paulo; I passed all tests were two days of chipping. I got the job. I gave all my documents, filled out forms, I went through medical examination and only have d wait for the phone call that would indicate the beginning of training; this call did not come in ummês and I went there to see what was. Do you know what was the my place had closed and I would not be REQUIRED, they gave me all the documents and said they would call me when needed. Never more. I know what happened, but I have no means to prove!

 

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