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PrEP and Prejudice - The PrEP is not a silver bullet.

By Benjamin Ryan

Silver Bullet?

Silver Bullet?

  Can personal choices and public health find a common denominator in pre-exposure prophylaxis? "PrEP is not a silver bullet." If you talk to a long list of HIV researchers and advocates about the controversial Truvada HIV prevention pill, you will hear a handful of them spontaneously utter this phrase literally.
Provide drugs to HIV-negative people is not intended as a panacea that will put aside all other methods of prevention, an expert says. And only time will tell if the pre-exposure prophylaxis (PrEP, in English) will really help inhibit the HIV epidemic in the US, particularly among gay men.
Achieving public health success depends on whether Truvada ends up in the drug cabinets of a critical mass of people at high risk of contracting HIV, and whether they end up adhering well to the daily regimen. It has been more than two years since Truvada, a tablet that includes the antiretrovirals tenofovir and emtricitabine, common in the treatment of HIV has been okay for use as a preventive to the virus. Ink rivers have been spilled in the last 12 months over the apparent warm uptake of PrEP. But recent evidence suggests that PrEP is finally starting to become popular with gay men and that a flourishing revolution may be upon us. What is already abundantly clear is that providing medicines to HIV-negative people with a drug that can have as much as 100 percent effective in preventing HIV can be a powerful transformation at the individual level. Of the dozens (almost all gay men) who shared their stories to this article under taking PrEP, many described a personal and sexual rebirth that caused a change in life as, for the first time, they discovered what it is to have sex without fear.
"The PrEP made me feel good about being gay," says Evan (one of which preferred to use only his first name), a sex professional full-time 22 years who lives in Washington, DC "Growing being gay is still very difficult. The first thing we learn about our sexuality is that some people do not like us, and that we probably contrairemos HIV. Taking PrEP allowed me to enter my sexuality and feel powerful. "
PrEP, he adds, "has led me to accept all gay men as potential friends, sexual partners or life partners regardless of their HIV status." Quentin Ergane, 38, who works as a home care provider for adults with mental illness in Seattle may be the perfect candidate for PrEP. Despite being very familiar with the alarmingly high rates of HIV among your male African-American friends who have sex with men (MSM); despite seeing his father, his favorite cousin and his best friend all die of AIDS-related causes; despite a paralyzing fear of becoming HIV-positive; and despite knowing that condoms could help protect him, he has used them only indiscriminately since his domestic partnership ended in 2009. Man Withdrawing the wooden card painted the the gay pride flag "Leaving a period of 10 years without using condoms and now that you are single have to go back to use them, I just did not have the feeling that I was approaching anyone," Ergane says, adding that the decrease in pleasure during sex is another factor, if less important, contributing to their contempt for the latex which is a common refrain among gay men.
"Not always occurs to me in the heat put on a condom," he says. "Also, this attitude is very unnatural. People really disrupt your privacy, your connection, your passion, your everything, and then put a condom and expect things to go back to the same level? "
After starting with PrEP earlier this year, "I finally felt free," he says. "For the first time since I was a boy, I know my sexuality will not be the cause of my death." *** When gay men describe not using condoms despite intentions to do so, they will generally use language suggesting was an accident largely beyond his control: "It was a slip." Some may even describe it as an extra-bodily state of mind: "I realized that my compatibility with condom use had changed." Critics may argue that this elevates to a trick of a conjuring conjurer to deflect justifiable guilt by failing to develop a rational process. However, as John Guigayoma, an 28 boy from San Francisco, can attest, sex has a powerful ability to get over such reasoning. Like Ergane, Guigayoma discovered that his sexual behavior was going against the HIV prevention practices he was teaching - and in his case, he was also teaching others. Despite working at a health education provider, he wore condoms sporadically as he struggled with the shame and guilt of leading a sex life that was making him incredibly unhappy, confused and lost. "I felt that I could not trust myself and that there was something wrong with me," Guigayoma says. "That just added to all my own shame: I'm not doing what I should be doing." Sarit Golub, MD, PhD, a psychologist at Hunter College in New York City who is studying the use of Truvada by gay men, says the biggest benefit of PrEP is that it "separates the HIV prevention act from the potential encounter event," allowing the rational mind to run the show. "I can not rely on myself to use the condom," Ergane says, "but I can rely on myself to take this pill every day." male prostitution"The PrEP helped me take control," says Guigayoma, which started with Truvada a year ago. Reducing your risk of HIV with drugs gave him the chance to take stock of your life and take better care of yourself holistically. Part of this process was to forgive to prefer sex without latex. "Perhaps there is nothing wrong with me," he explained. "Maybe this is just the way I want to live my sex life." Such sexual life includes an increased risk of sexually transmitted infections compared to those who are faithful to the condom. Activists of PrEP believe that those taking Truvada following the advice of the Centers for Disease Control and testing for STI at least twice a year will lead to early diagnosis and that subsequent treatment will counteract the absence of latex. However, such realistic attitudes toward condoms are causing deep concern and even anger among some in the gay community. "No wonder people think I'm irresponsible," says Guigayoma. "But it's more responsible to recognize the reality of our sex lives and to give people options they can work with than to dictate a particular pre-vention tactic." Okay to treat HIV since 2004, Truvada has a long history of supporting the notion that monitoring is generally safe and well tolerated, and that doctors can easily monitor any development of renal dysfunction or reduction in bone density - the two major side effects of long-term use. The issue of drug resistance can be uncertain, however. Research do iPrEx study showed that no one who contracted HIV during the study developed resistance to the drug. But most participants have been tested for HIV monthly, since anyone who maintains the CDC minimum requirements for PrEP will only receive quarterly HIV testing - giving the virus more time to muck. Another concern is that PrEP can lead gay men to increase their sexual risk-taking, a phenomenon known as risk compensation. The argument is usually framed as one or between Truvada and preservatives - take the pill, drop the latex - although in reality overlap in use seems common. Such rigid and dualistic thinking fits in with the popular saying that "condoms have failed" with gay men - a defeatist claim that fails to recognize that without latex HIV rates would probably be catastrophically worse. Other elements typically overlooked in this debate are the many behavioral practices that gay men also use to reduce the risk of HIV, and which can factor in risk compensation, such as: "seroposicionamento", in which the HIV-positive partner is on position passive or below; "Serotriagem" in which men try to have sex with the same serostatus partners; favoring oral sex instead of anal sex; or by the partner who is over (active partner) remove the member before ejaculation. None of the PrEP studies showed any evidence of risk compensation. In fact, both in the placebo phase and the open extent of iPrEx, volunteers, all of whom received risk reduction counseling, tended to behave less risky. But as the gay world begins to discover PrEP, a different story can begin to emerge. In an interview in the winter, Robert M. Grant, chief researcher, physician and Master of Public Health, a university professor at the University of California, San Francisco, was adamant that Truvada did not lead to risk compensation. But when summer came he acknowledged that he was beginning to hear anecdotes about it. Those looking for such a story did not have to go far to find the unofficial PrEP poster boy: Damon Jacobs, a Manhattan therapist who won the title by retelling his experiences with Truvada on dozens of media channels. Uncontrolled in his enthusiasm for this form of HIV prevention, he has not been remorseful about switching from inconsistent condom use to an almost completely free latex existence since PrEP began. This did not prove the paucity of people dividing their own experiences with the PrEP for this article which they reported engaging in varying degrees and various types of risk compensation. Some took Truvada with the clear purpose of opening the condoms. Quentin Ergane, for example, is now enjoying falling more often during sex. However, both are having fewer sexual partners lately. Time will tell how common risk compensation will become. A crucial question is whether those who have taken greater risks will also take their medicines. A combination of widespread risk compensation and irregular adherence to PrEP could push HIV rates in the wrong direction. And if the risk compensation among people taking Truvada influences similar behaviors in others, HIV rates could increase among non-users of PrEP. *** "PrEP works if you take it," according to researcher Robert Grant.
In fact, no one in the iPrEx study or in your open-contracted HIV while taking Truvada four or more days a week. But even if Truvada offer a type of protection "bulletproof" we do not know if it will reduce the 50, 000 new cases of HIV hell-bent on consist in the United States each year.
The key to the success of PrEP spread tailored, according to Anthony Fauci, MD, director of the National Institute of Infectious and Allergic Diseases, is that the field of public health stop "to cheat saying HIV is a 'equal opportunity employer'. " Approximately two-thirds of HIV infections in the United States are transmitted through gay sex. In fact, the group of men who have sex with men (MSM, in English) is the only category of risk that recently did not change the scenario: while heterosexuals and injection drug users have seen rates fall in recent years, the rates among gay and bisexual men only increased, especially among young people.
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This does not mean that all gay men should start taking a blue pill every day. There is still a big risk spectrum within the community. Take into account the estimate that perhaps less than 2,5 percent of sexual encounters between men involves one ejaculatory partner within the other's rectum - the act is by far the most likely to transmit the virus. Arguably the most effective way to increase the power of PrEP is to target HIV-negative men who are not consistently using condoms, and especially to those who are below when the partner ejaculates inside them. (This demographic priority would exclude men in a monogamous relationship or with another HIV-negative man or an HIV-positive man who has had the virus suppressed and is in regular care with HIV.) "My focus is not to help the well-concerned get access to PrEP, "says Jim Pickett, director of prevention advocacy at the AIDS Foundation in Chicago. With such priority in mind, resultados July of the open phase of iPrEx are encouraging: those at highest risk of contracting the virus were both more likely to follow PrEP and were more likely to adhere. However, overall adherence was dramatically lower among younger participants. Hopefully, the benefits of PrEP will extend to individuals taking Truvada. According to Demetre Daskalakis, MD, Public Health Master, new health care commissioner at the Center for AIDS Prevention and Control at the New York City Office, "PrEP, given the right population at risk, is not really only HIV prevention, but specifically it is acute HIV prevention. "Indeed, during the first six to twelve weeks of infection - a time period known as the acute phase - viral loads soar, making HIV transmission much easier. During this phase, a person may feel perfectly fine and continue to engage in the kind of high-risk sex that exposed him to the virus in the first place, thereby helping the virus clear its way through its "network of sexual contacts." So, ultimately, PrEP can operate as a wire cutter that breaks the current. *** As for bringing PrEP to a critical mass, much has been done estimate of the manufacturer of Truvada, Gilead Sciences, that only around 2,300 people are taking PrEP. But this data has many limitations that are usually neglected: it reflects only September data from 2013; he was slaughtered by only 55 percent of North American pharmacies; and it excludes the thousands who are taking PrEP through studies. Numerous health care providers who have been contacted for this article have reported that since the buzz of the media began in 2013, they have seen an oscillation of 2, 5 or even 20 times higher in prescriptions. TruvadaAbstr "We've had a tremendous increase in interest," says C. Bradley Hare, MD, director of HIV prevention and care services at Kaiser Permanente Medical Center in San Francisco, where 250 patients are in PrEP, compared 40 years ago. "It has grown and been in the last year." Why would PrEP candidates choose not to take it? To begin with, there is the possibility of barriers with insurance (although in PrEP they are usually covered), concerns about side effects (founded or unfounded), an unwillingness to take a medicine every day, and fear of being stigmatized as a person promiscuous who has unprotected sex. But the biggest blockade for gay men could be their own lack of information that PrEP could personally benefit them. Daskalakis has recently published a study with gay men at New York City meeting points who found that of the 80 percent who were potential candidates for Truvada, more than three-quarters did not think they were at risk enough to use PrEP. But perhaps the strongest case for PrEP is not necessarily made from the context of anonymous dating. Research critically neglected suggest that gays are many more likely to use condoms in a chance encounter and that between one third and only above two-thirds of transmissions between men occur with their primary partners. In other words: a lot of guys are contracting HIV from boyfriends, not from sexual encounters. The transmission window seems to be open usually when there is a need to show confidence and experience intimacy in a new relationship leaves the condom aside - before men have been tested for HIV and discussed monogamy. *** Unfortunately, an unpublished study led by New York University professor of psychology and public health Perry Halkitis, PhD, Master of Public Health, found that young MSM in romantic relationships were less likely to see use in taking Although they did not use condoms. On the other side of the coin are recent discoveries of a published study recently co-authored between Kristi Gamarel, PhD at Brown University and Sarit Golub of Hunter College who studied adult MSM men in New York City - a set of older men, with a mean age of 32 years - who were in stable relationships in which the two were HIV negative. When men cited intimacy as the reason they had unprotected sex with their partners, the likelihood that they expressed interest in PrEP rose to 55 percent. Those who reported having had unprotected sex with someone other than their partner were also more likely to say they would use PrEP. As well as should be taken into account that HIV targets MSM blacks more disproportionately: They make up about a fifth of all annual infections in the United States. Young black MSM are at particularly higher risk. An alarming 12 percent of young black MSM in Atlanta contract the virus every year. The key to engage this demographic population, said Phil Wilson, founder and CEO of the AIDS Institute in Negros, is to use targeted efforts for equal. "Someone comes in with a sneaker or rap music or a T-shirt and gets popular in the Bronx," says Wilson. "Four days later it's on the billboards in Watts and Compton. So there are in-game mechanisms that are used every day to reach young blacks. "Unfortunately, trying to get Truvada usually means battling with primary care doctors who refuse to prescribe a prescription they are unfamiliar with, with which they believe it will lead to risk compensation, and which they mistakenly find highly complex to monitor safety. Part of the problem stems from Gilead's decision not to advertise Truvada as PrEP. Instead, the company makes modest donations to community groups, universities, and public health agencies that take time off by educating the public and doctors. This remains a stark contrast to the disclosure of birth control in the 60 years, when GD Searle & Company has sent an army of "meticulous men" clinics to clinicians to promote contraceptive Enovid. "In some cases, because the gay sex be so stigmatized, it is leading doctors to make inappropriate judgments," says Jose Zuniga, PhD, Master of Public Health and president of the International Association for AIDS Care Providers. Until recently, the clinic Kaiser Permanente in San Diego called for those looking for PrEP sign a form that warned, "At any time, the Contractor may consider stopping the PrEP if there is continuing evidence of risky sex or is positive for DST's." No matter that both have sex without a condom as sexually transmitted diseases on the list of what makes someone a candidate for PrEP first. Lisa, a woman of 34 years living in a big city on the East Coast that are wanting to conceive of their HIV-positive boyfriend first asked her gynecologist about PrEP. "As soon as I told her that my partner was HIV-positive, the look that woman gave me was disgusting," Lisa remembers. "She spoke to me as if I were an irresponsible person and the scum of the earth." As it is apparently highly common, Lisa's doctor told her to consult an infectious disease doctor, who then told her not to look for HIV- negative and that she would go to her first doctor, subjecting her to months of comings and goings as she sought out a doctor who sympathized with PrEP. "It was so humiliating," Lisa said. Daskalakis, in turn, fears that experiences like Lisa mean that medical specialists will become the large group who prescribe Truvada and that ordinary doctors will do tests to select potential candidates for PrEP. *** Promising efficacy data aside, troubling findings have emerged in the open phase of iPrEx: participants took four or more pills a week only 33 percent of the time and adhered daily 12 percent of the time. Fortunately, it seems that MSM taking Truvada can lose up to TRE doses per week and are likely to remain completely protected. It is estimated that even taking the pill only twice a week reduces the risk of HIV by 76 percent. In this perspective, there is hope that the first discoveries of a continuing study of the use of the PrEP in the real world between the MSM and the trans women in San Francisco, Washington, DC, and Miami. One month into the study, participants were adhering four or more times a week at rates of 92 percent, 90 percent, and 73 percent, in their respective cities. Daily adherence, however, was only a respective 66 percent, 45 percent and 19 percent. And if this study follows the open-phase tendencies of iPrEx, adherence rates may fall over time. Michael Weinstein, president of the AIDS Healthcare Foundation (AHF), a media advisor to citations opposed to PrEP, insists, "There is no evidence in the scientific literature that PrEP is a successful approach to public health." He points to the fact that low adherence has pulled population-level efficacy down, and then it demonstrates average risk-reduction data as failures. THE media campaign "Facts Prep" is opposed to PrEP as an intervention in public health for these reasons. But another way to look at a median effectiveness of 44 percent is to say that if you give PrEP to a good number of high-risk gay men, HIV rates will decline. These data are also reduction about 60 percent in woman's risk of transmission to man that male circumcision confers. Research is beginning to show that the massive campaign to circumcise African men are not only connected to reduce HIV among circumcised men, but also among women. Which brings us back to Daskalakis's point that PrEP can effectively prevent people from transmitting HIV to others by keeping people who are having high-risk sex from contracting HIV in the first place. Weinstein's ultimate argument is that the dominant prevention approach should focus on promoting the use of condoms along with the treatment and diagnosis of HIV-positive people, and that PrEP should be reserved for "special cases." In fact, Recent research suggest that having an undetectable viral load makes it virtually impossible for people living with HIV transmitting HIV. But poor adherence to antiretroviral also pulls down the effectiveness of population-level "treatment as prevention" (TASP in English): A estimated 75 percent of Americans treated for HIV actually have a totally suppressed virus. Another way to look at this is that only 40 percent of all Americans diagnosed with HIV are on treatment and only 30 percent are virally suppressed. Recognized, giving drugs to individuals with HIV is a much more targeted way of containing transmissions than giving Truvada to HIV-negative people hoping to prevent any HIV they may encounter. But all these things considered, PrEP is still being held to a much higher standard: adherence is always factored into the debate over its merit while that element is largely ignored when discussing the TasP. Moreover, only a minority of MSM apparently adheres consistently to the condom. "There is not a single person I know who thinks PrEP is perfect or that adherence is a critical issue," says Mitchell Warren, executive director of the Global HIV Prevention Support Group (AVAC), who added that adherence is critical to all forms of HIV risk reduction. "If there was a perfect intervention, we would prefer it," he says. "But in 2014 the best approach is a Patchwork approaches good, but not perfect. Why would we want to give up any of them does not make sense to me. " By the Numbers Considering the effectiveness Prep 44 percent In the experiment iPrEx with MSM and transgender women who were the first to demonstrate the effectiveness of Prep 2010, the group given Truvada had a reduction of infection by HIV 44 percent rate compared with the placebo group. 92 percent Only 51 percent of participants assigned to take Truvada in iPrEx detected the drug in their systems, but they had a reduction of HIV 92 percent rate compared with those with no detectable drug. The American Center for Disease Control and Prevention (CDC) incorrectly the consistent use of Truvada reduced the risk of HIV in "to 92 percent." The data is not the upper limit of risk reduction of Truvada with perfect grip; it represents a risk reduction of average among those taking absolutely no drug. 99 percent   A specific modeling (Called regression analysis) based on the data iPrEx designed to take Truvada seven days a week reduces the risk of HIV 99 percent. The real data, researchers estimate could be between 96 percent and greater than 99 percent. 100 percent Na placebo free phase iPrEx researchers analyzed the data with what is called stratified analysis, which allowed the evaluation of them reflect more directly the fact that, as early in the iPrEx, nobody contracted HIV while taking Truvada four or more days a week: they designed to adhere to the regime that offers favorably 100 percent efficacy. A drawback of using this different way of statistical analysis was a range of broader estimates: they could only speculate with confidence that the efficacy was nothing less than 86 percent.
About Claudio Souza do Soropositivo.Org (507 articles)
Yes, this is the photo of me! My niece asked me to put this picture on my profile! .... I had here a description of me that one person described as "irreverent". This is really a euphemistic way of classifying what was here. All I know is that an "NGO" which occupies a building of 10 floors has established a partnership with me, and I have the logs of the partnership time, which was more a vampirism because for each 150 people leaving my site, clicking on them, there was, on average, one that came in. WHEN I ENTERED AND ENTERED

2 comments PrEP and Prejudice - The PrEP is not a silver bullet.

  1. Hoan Andrade // 19 June 2016 to 13: 17 //

    Why instead of making use of PrEP, people who want to unprotected sex do a quick test of HIV, Syphilis and Hepatitis, because there are these other diseases as well, and with the rapid test person already discards three diseases once, not just one. There will be safer to do this procedure ????

    • I think vc is very demanding of people.
      Djavan wrote:
      "Being love, invades and end ..." This responds to your questioamento

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