More than 25% of HIV-positive people develop OHL at some point during the course of their infection. It is more common among men and smoking HIV-positive.
What is and what symptoms?A Progressive Multifocal Leukoencephalopathy (PML, in English) is an infection in the brain that life-threatening and can occur in people living with HIV. It is caused by a virus - the JC virus. "JC" are the initials of the first patient to be diagnosed with PML. The polyoma virus is a virus of the family which includes human papillomavirus (HPV).
The "progressive" term in PML means that it continues to get worse and usually leads to severe brain damage. The term "multifocal" means that the virus "JC" cause diseases in various parts of the brain. The "leukoencephalopathy" means that the disease affects the white matter of the brain. More specifically, the JC virus infects brain cells called oligodendrocytes. These cells are responsible for producing myelin, a fatty substance that helps protect the nerves in the brain. If too much myelin is lost and not replaced by oligodendrocytes, the nerves are damaged and often stop working correctly.Over 85% of adults worldwide are infected with the JC virus, usually during the early childhood years. However, the virus only becomes active in people who have an active immune system. This includes people undergoing immunosuppressive chemotherapy for cancer and people with compromised immune systems due to HIV. Before using the combination of antiretroviral (ARV) therapy, it was estimated that between 3 and 7 percent of people with AIDS developed PML. It usually occurs in people with very low CD4 cell counts (less than 100) but was seen in some HIV-positive people with CD4 cell counts in 500. In the early years of the AIDS epidemic, PML was often progressive and fatal. Death occurred between 1 and 4 months after the onset of the first symptoms. While the diagnosis of PML today remains rapid in its progression and possibly fatal, improvements in our ability to stabilize the immune system using HIV drugs have helped improve the prognosis associated with this opportunistic infection. PML symptoms include mental deterioration, loss of vision, speech disorders, ataxia (inability to coordinate movements), paralysis, and coma. In rare cases, seizures may occur. As injuries and nerve damage can occur in any part of the brain, the initial symptoms may be different among people with the disease. Translation Rodrigo S Pelegini