Progressive Multifocal Leukoencephalopathy (PML)

Image default
Articles serious illness Oportunisas Diseases Opportunistic diseases ?! AIDS-related illnesses January 2015

O What is it and what are the symptoms?

Progressive Multifocal Leukoencephalopathy (PML) is a brain infection that poses a risk of life and that can occur in people living with HIV. It is caused by a virus - the JC virus. “JC” is the initials of the first patient to be diagnosed with PML. The virus is polyomavirus, a family of viruses that also includes human papillomavirus (HPV).

idea in head

The "progressive" term in PML means that it continues to get worse and usually leads to severe brain damage. The term "multifocal" means that the virus "JC" cause diseases in various parts of the brain. The "leukoencephalopathy" means that the disease affects the white matter of the brain. More specifically, the JC virus infects cells in the brain calls oligodendrocytes. These cells are responsible for producing myelin, a fatty substance that helps protect the nerves in the brain. If too much myelin is lost and not replaced by oligodendrocytes, the nerves are damaged and often stop working correctly.

More than 85% of adults worldwide are infected with the JC virus, usually during the early years of childhood. However, the virus only becomes active in people who have low immune system functioning. This includes people undergoing immunosuppressive chemotherapy for cancer and people with compromised immune systems due to HIV. Before antiretroviral therapy (ARV) combination use, it was estimated that between 3 and 7 percent of people with AIDS developed PML. It usually occurs in people with cell counts CD4 very low (less than 100), but was seen in some HIV-positive people with a CD4 cell count in 500.

In the early years of the AIDS epidemic, the PML was often progressive and fatal. Death occurred between 1 and 4 months after the onset of symptoms. While the diagnosis of PML today remains rapid in progression and possibly fatal, improvements in our ability to stabilize the immune system using HIV drugs have helped improve the prognosis associated with this opportunistic infection.

PML symptoms include mental deterioration, loss of vision, speech disorders, ataxia (inability to coordinate movements), paralysis, and coma. In rare cases, seizures can occur. As injuries and nerve damage can occur in any part of the brain, the first symptoms may be different among people with the disease.

Source AIDSMEDS

Translation into Portuguese from Brazil: Rodrigo S. Pellegrini

The texts below may interest you!

One person already said something !!! And you will be left out!?

Hi! Your opinion always matters. Got something to say? Is here! Any questions? We can start here!

This site uses Akismet to reduce spam. Learn how your feedback data is processed.

Automattic, Wordpress and Soropositivo.Org, and I, do everything in our power regarding your privacy. And we are always improving, improving, testing and implementing new data protection technologies. Your data is protected, and I, Claudio Souza, work on this blog 18 hours or day to, among many other things, ensure the security of your information, since I know the implications and complications of past and exchanged publications. I accept the Privacy Policy of Soropositivo.Org Know Our Privacy Policy

%d Bloggers like this: