Burkitt's lymphoma, AIDS-related disease

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Opportunistic Diseases! What are?! And What Are They?
Burkitt's Lymphoma, SeropositiveOrg Burkitt's Lymphoma - This Disease Has Taken Me Someone Important
I met a woman, who lived in search of a prince encando that she could never, in life, find. Although I know her name, she would rather be called Amaryllis.
We were great friends and she even introduced me to Sandra Stone. And, six hands. we did a project to relocate HIV positive people to the job market. A few months ago, I reread the project and realized, stunned, that there must be something in the water tank that feeds the house of our mutual friend, because the project was without head or foot. And, in what I dare not call the body, there was only the exacerbation of everything hereolo that we, the three of us, but deplored!
And I remember that we are going to work with a “determined” NGO and the person in charge of the site didn't even want to read the project, as it is very large (15 pages). Thank God, I think now! They didn't read!

But the theme here is Burkitt's Lymphoma

You, who read me, must know. No one gets a second chance to make a good first impression.
But we met and I remember that me, my wife and Amarílis went to the birthday party at a disco there on the XNUMXth of July. She, Amarilis, did not know, but Burkitt's Lymphoma had already “started her Work!

Burkitt's Lymphoma Is A Potentially Fatal Opportunistic Disease!

CTHA, my friend, do not understand that you may be at this risk, your exams are right and the simple fact that I know this disease, Burkitt's Lymphoma, would be enough for me to go to Andromeda looking for a solution to your problem, your fears and doubts. Just read the primary text about immunological window
I'm reviewing the others! A little bit
Life flowed naturally after that. And when I say naturally, I mean that there was also a loss… 🥺🥺🥺
Once I was in Santos and I remembered calling Amaílis only by wave; it was a wednesday and she was there while I was at the sea, enjoying the sun in Santos….
And that was what I intended to say to her, when she answered the phone and in the meantime, it was her brother who answered the phone, who explained to me that she had woken up a few days ago unable to move her legs and, because God is great , she had the cordless phone in bed and called Sandra.
I will not dwell on that and the fact is that her agony was painful and short. In fifteen days she had passed away.
At the time, her death certificate had, as a cause of death, non-Hogkin's lymphoma; who has finally been identified as Burkitt's lymphoma.
Unfortunately, I wanted to look for a photo referring to the disease and I will regret having found it until the end of my days.
That is why I put this article here.
Amarilis passed away in mid-2003 and is almost 12 years after her death. Anyone who wants to know more about it, just read the text named "At such a time to tell in memorian"

Burkitt's Lymphoma, SeropositiveOrgO Burkitt's lymphoma (Formerly High-grade non-Hodgkin's lymphoma of small non-cleaved cells) is a highly aggressive mature B cell neoplasm (cancer) that affects mainly the younger age group, being endemic in African regions.

T (8; 14) (q24; q32) - translocation of genetic material between chromosomes 8 and 14 - occurs in 80% of cases. The other 20% correspond to (2; 8) (p12; q24) and (8; 22) (q24; q11).

All of these cytogenetic changes involve the overexpression of a gene with multiple cellular functions called c-myc. This gene is decisive in the development of this pathology.[1]

Histological sections of the tumor may have the appearance of a “starry sky” (starry sky). There is an association between infection by the virus Epstein-Barr virus (EBV) and the development of Burkitt's lymphoma.

It often presents with extra nodal disease. The carriers can be affected mainly in the bone structures, with massive oral lesions, the mandible being the most affected bone. It can also affect several structures, including kidneys and ovaries.

Burkitt's lymphoma cells are morphologically identical to cells of acute lymphoid leukemia, subtype FAB L3. Cellular immunophenotyping reveals CD20 positivity in the vast majority of cases.

The first description of this disease was made in 1958 by Irish physician Denis P. Burkitt, who observed a high prevalence of a highly aggressive tumor that endemically affected children in equatorial Africa.

It was initially described as sarcoma (cancer of the soft tissues), but later it was observed that it was a primary tumor of the lymphatic system (lymphoma).

Burkitt's lymphoma and acute L3 lymphoid leukemia (Burkitt's leukemia) were believed for many years to represent different diseases. However, with the advent of modern techniques of chromosomal and genetic analysis, it was possible to determine that both represented symptoms of the same disease.

In 2001, the World Health Organization (WHO) classified these conditions as being a single entity (mature B cell neoplasia, subtype Lymphoma / Burkitt's Leukemia), with three clinical variants.

Clinical variants

According to the WHO, three clinical variants are identifiable:

  • Endemic variant: occurs in children from equatorial Africa where malaria is endemic and has a high correlation with EBV infection (98% of cases). It is believed that the status of chronic immunodepression caused by malaria contributes to the development of the disease.
  • Sporadic variant: affects children and adults from other geographical areas. It is associated with EBV infection Epstein-Barr virus) in 5-10% of cases.
  • Associated with immunodeficiency: in most cases associated with infection by the human immunodeficiency virus (HIV). The association with EBV co-infection is between 25-40% of cases.

References

  1. Hecht J, Aster J. (2000). "Molecular biology of Burkitt´s lymphoma". J Clin Oncol 18: 3703.
  2. Burkitt D. (1958). "Sarcoma involving the jaws in African children". Br J Surg 46: 218.
  3. Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology & Genetics of Tumours haematopoietic and lymphoid tissues. [Sl: sn], 2001.

From Wikipedia, the free encyclopedia

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