Scientists in the United States, working on a cure for AIDS said they found important clues about how HIV is "camouflage" to prevent the immune system to eliminate completely of the HIV in the body, even after the suppression of the bloodstream by drugs make up the cocktail.
The sleeping virus, and mutates to escape detection by the immune systemHas been the great enigma in the quest for AIDS cure.
Now, the good news is that, thanks to laboratory experiments on the immune system, we are finding a way to track the virus and eradicate it, enthuses Robert Siliano.
The research, published in Nature, described as "kick-and-kill" (kick-and-kill strategy in free translation), was the pivot of research in this ambitious campaign war 33 years against AIDS.
HIV, which causes AIDS, is hidden in the cells CD4 TAlso known as "memory cells", one of the components of the immune system after infection by antiretroviral be reversed, is the conclusion of the study.
Noting that, once the therapy is stopped, the virus recovers. The study said the focus of therapy capable of expelling the virus with powerful drugs and eliminate it, so that HIV was "forced" to leave their hiding place and returned to circulate in the bloodstream.
Whereas 40 million lives were lost in the last three decades, with 78 million people infected with HIV (Translator's note: This data is the author of the text), Any advance is a big jump in curing diseases like AIDS.
During the study, the team analyzed the blood of HIV-positive people 25, distributed so that 15 them initiated antiretroviral therapy soon as they were diagnosed, and another ten in the infection spread and became chronic.
Those who were quickly initiated therapy managed to stop the reproduction of the virus and not allow its mutations.
On the other hand, those who received antiretrovirals later "allowed" that HIV suffer numerous mutations, forming a "community" with various strains, generating what call "escape mutations" that were undetectable to the "immune sentinels".
Realizing that shortly after discontinuing antiretroviral medication the virus' counter-attacked "and returned to act in the patients in question, the study focused on the therapy" Kick-and-kill "(kicking and killing in free translation) to "kick" the virus with potent drugs and eliminate it so that the virus was "forced out of infected cells."
Whereas due forty million (Estimates)were lost because of AIDS and taking into account a universe estimated at around thirty million people are HIV positive for HIV or living with AIDS (Translator's note: these figures are estimates of the result of the author of this study) whereAny step forward, however small it may seem, is a big jump!
Solution in sight for Positives
The aim of the research is to move towards a possible solution to the central problem that is ultimately eliminate HIV from the body of these people, the chief scientist said. Our results suggest to us that if we can attract the HIV out of hiding, we will have won half the battle, said Robert Siliciano, professor of molecular biology at Johns Hopkins School of Medicine, Maryland.
Found "latent virus pools" that carry mutations that make the HIV virtually invisible to the cells of the human immune system.
But we are almost sure to disarm him, even when the virus comes out of hiding and evade detection from the immune system, concluded Siliano.
In their research, the scientists exposed immune cells not infected without the virus; some have been exposed to HIV and who underwent a mutation, while others were exposed to the virus kept, or, as scientists say, "wild". Those who were not exposed to the virus eliminated maintained 61 percent dinfected cells. But those with the immune system mutant HIV-infected cells responded poorly, deleting only 23 percent of infected cells, a bad result.
"It's like the imunitlógico system had lost its ability to detect and destroy the virus; however, CD4 Killer T cells are still able to recognize a different part of the virus, a part that does not suffer mutations in the HIV protein, awakening a natural immune response, Siliciano said in a press release.
Sharon Lewin, director of Infection and Immunity Institute in Doherty, Australia, proved to be excited about the findings and implications of this study.
The study highlighted the need for an additional boost to the immune system to clear the virus from the body expelled from the reservoirNoted scholar.
Research continues in the search for solutions.
Translated by CSS from Original Cure For AIDS In Sight As Scientists Zero In On Methods To Neutralise Drug Evading HIV
Note the Seropositive Web Site Editor: Note that the best result eliminated just a little more than 60% of HIV-infected cells not mutant and this definitely is not cure for AIDS; only a hope for the future. Still will take years of research to find a solution (or solutions combined) to eliminate HIV completely from the infected host, and that here reported experience was an made with clinical laboratory controland there is no prospect of it for this procedure before the end of this decade or later, e the condom is still the best option when it comes to HIV prevention.