Thanks to the wide availability of potent anti-HIV combination therapy (commonly called ART-therapy antiretroviral or HAART), many HIV-positive patients are living longer and researchers increasingly expect that some of these people reach old age. HIV-positive people with advanced age, the risk of diabetes type 2 and other complications related to aging are likely to increase. The precursor of diabetes type 2 is insulin resistance and discuss this in the next opportunity.
The hormone insulin helps move sugar (glucose) in the blood into the cells. Inside the cells, the sugar is converted into energy. Relatively stable blood sugar levels are needed to help the body organs perform their best. In some people, the cells become less responsive to insulin and a development called insulin resistance. To compensate, the pancreas gland produces more insulin, and this "tactic" works for a while in some cases for years. But with the passing of time,If no measures are taken to reverse insulin resistance (This link opens in another tab of your browser, and another site, which is in English. I take personally committed to translate it into a maximum of 30 days from the date of publication of this article) With the guidance of a doctor, the problem may worsen. Finally, despite the increasing insulin production, resistance to the effects of this hormone becomes overwhelming and diabetes type 2 develops.
As part of a study (called HEPAVIH ANRS CO-13) researchers in Marseille and in other regions of France have been monitoring the health of HIV-positive patients co-infected adults with hepatitis C virus (HCV). The researchers collected information on participants through questionnaires, blood samples and more reports. Some of the questions posed to participants treated with the use of substances, including marijuana.
The researchers found a statistical relationship between marijuana use and a possible decrease in insulin resistance risk.
The total number of study participants was 1.324 people. However, researchers excluded those with diabetes or insufficient data for the final analysis. This left 703 participants, who were the focus of this analysis. The profile of these 703 participants at enrollment was as follows:
- 68% Of men, 32% of women
- Average age - 44 years
- Most participants (69%) had CD4 + count above 350 cells / mm3
- Most participants (72%) had a viral load below 50 copies / ml
The questionnaire asked participants if they used marijuana and how often.
The researchers found that, in their first study visit, 46% of respondents revealed that they had used marijuana in the past four weeks, distributed as follows:
- Occasional use - 21%
- Regular use - 12%
- Daily use - 13%
Having several factors into account, the researchers found that participants who used marijuana were less likely to have insulin resistance.
In addition, the researchers found that drinking coffee was associated with a decreased risk of insulin resistance.
Have in mind
This study was observational in design.
Such studies do not allow to take definitive conclusions between cause and effect. In other words, this study can not prove that marijuana use, in fact, reduces the risk of insulin peripheral resistance. Observational studies can never rule out the possibility of some other factor not measured during the study may not have been noticed, may have distorted the conclusions when interpreting the data. The findings of this study, therefore, need to be carefully analyzed. However, the study is a good first step to establish a possible link between cannabis use and a decreased risk of insulin resistance in HIV-positive patients. This study was necessary because some observational data of HIV-negative people in the US also suggest an association between exposure to marijuana and a reduced risk of insulin peripheral resistance. Doctors in Quebec, working with Inuit people have also found in observational studies, that marijuana, apparently, can help reduce the risk of insulin peripheral resistance. Despite these findings, other observational studies in HIV-negative patients did not find a beneficial association between marijuana and peripheral insulin resistance.
The need for good data
Doctors who treat people with insulin resistance is necessary company data than to make recommendations on the safety and the potential use of marijuana for the management of this condition. There are many questions that require answers that are relevant to the problem of insulin resistance, such as the following:
- What does marijuana in human metabolism in order to reduce the risk of insulin resistance?
- What compounds in marijuana can be responsible for reducing the risk of insulin resistance?
- How many times marijuana be used to help reduce the risk of insulin resistance?
- Which is more effective in reducing the risk of insulin resistance-coffee or marijuana?
- It marijuana as effective as the widely used and relatively inexpensive sensitizer metformin to insulin? (Note that metformin is based on an extract of a plant).
- How marijuana should be administered to the patient (smoked or ingested) to get the best effect against insulin resistance?
- Marijuana helps all people with insulin resistance?
- Marijuana and other drugs used to treat insulin resistance interact? If so, how?
- How secure is the use of marijuana for people with insulin resistance and other coexisting diseases such as cardiovascular disease, lung disease and so on?
The French present study was not designed to answer these important questions.
However, well targeted and robust clinical trials could be developed to provide exhaustive answers to these and other issues surrounding peripheral insulin resistance and the potential medical use of marijuana.
Such tests are likely to be expensive and will require a long time to implement and eventually interpret the captured data.
However, by working with a doctor, specifically a (a) endocrinologist, making dietary changes, encouraging regular exercise and taking practice of religious and critical manner prescribed medication, it would be possible to control and reduce insulin resistance and reduce thus the risk of diabetes type 2.
- The Diabetes Drill-Bright Side
- Canadian survey compares marijuana use across different conditions-CATIE News
- About Diabetes- Canadian Diabetes Association
Diabetes- Health Canada
This information was provided by CATIE (Canada Exchange of AIDS treatment information). For more information, contact CATIE, 1.800.263.1638 or by email atCatie. The credit must appear on any online publication, with a link back to the original.
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Translation adjustment and revision of the original Canadian English into Portuguese of Brazil (it does not exist Brazil with "z" and "Brazil" is the idiomatic aberration created for persons que only God knows why They Do this and obscure intention Which They May Have ...) in the originalFrench study hints at marijuana's potential for Reducing diabetes risk by Claudio Souza