Due to the wide availability of potent anti-HIV therapy combination (commonly called ART-Antiretroviral Therapy or HAART), many HIV-positive patients are living longer, and researchers are increasingly hoping that some of these people will reach old age. With HIV-positive people with advanced age, the risk of 2-like diabetes and other aging-related complications are likely to increase. The precursor of 2 type diabetes is insulin resistance and we will discuss this in a near future.
The hormone insulin helps to pass sugar (glucose) from the blood into the cells. Inside the cells, this sugar is converted into energy. Relatively stable blood sugar levels are needed to help the body's organs perform their best. In some people, cells become less sensitive to insulin and a development called peripheral insulin resistance. To compensate, the pancreas gland produces more insulin, and this "tactic" works for a time, in some cases for years. But over time, If no measures are taken to reverse insulin resistance (this link opens in another browser tab on another website, which is in English, and I personally undertake to translate it into a maximum of 30 days as of the date of publication of this article). a doctor, the problem can get worse. Finally, despite increasing insulin production, resistance to the effects of this hormone becomes overwhelming and diabetes type 2 develops.
As part of a study (called HEPAVIH ANRS CO-13) researchers in Marseille and other regions of France have been monitoring the health of HIV-positive adult patients co-infected with the hepatitis C virus (HCV). The researchers collected information from participants through questionnaires, blood samples and various evaluations. Some of the questions put to participants treated with substance use, including marijuana.
The researchers found a statistical relationship between marijuana use and a possible decrease in the risk of insulin resistance.
The total number of study participants was 1.324 people. However, researchers excluded those who had diabetes or insufficient data for the final analysis. This left 703 participants, who were the focus of this analysis. The profile of these 703 participants entering the study was as follows:
- 68% Of men, 32% of women
- Average age - 44 years
- Most participants (69%) had a CD4 + count above 350 cells / mm3
- The majority of participants (72%) had a viral load lower than 50 copies / ml
The questionnaire asked the participants if they used marijuana and how often.
The researchers found that on their first study visit, 46% of participants revealed that they had used marijuana in the previous four weeks, distributed as follows:
- Occasional use - 21%
- Regular usage - 12%
- Daily usage - 13%
Taking several factors into account, the researchers found that participants who used marijuana were less likely to have insulin resistance.
In addition, the researchers found that drinking coffee was associated with a decreased risk of insulin resistance.
Have in mind
The present study was observational in its design.
Such studies do not allow definitive conclusions to be drawn between cause and effect. In other words, the present study can not prove that marijuana use actually reduces the risk of peripheral insulin resistance. Observational studies can never rule out the possibility of some other factor not measured during the study that may or may not have been noticed may have distorted the conclusions in the interpretation of the data. The findings of the present study, therefore, need to be analyzed with caution. However, the study is a good first step in establishing a possible relationship between marijuana use and a decreased risk of peripheral insulin resistance in HIV-positive patients. Such a study was necessary because some observational data from HIV-negative people in the US also suggest an association between marijuana exposure and a reduction in the risk of peripheral insulin resistance. Physicians in Quebec working with Eskimo populations have also found in observational studies that marijuana appears to help reduce the risk of peripheral insulin resistance. Despite these findings, other observational studies in HIV-negative patients found no beneficial association between marijuana and peripheral insulin resistance.
The need for good data
Physicians who treat people with insulin resistance need corporate data than to make recommendations on the safety and potential of marijuana use for the management of this condition. There are many questions that require answers that are relevant to the problem of insulin resistance, such as the following:
- What does marijuana do in human metabolism to reduce the risk of insulin resistance?
- What compounds in marijuana may be responsible for reducing the risk of insulin resistance?
- How many times has marijuana been used to help reduce the risk of insulin resistance?
- What is more effective in reducing the risk of insulin resistance-coffee or marijuana?
- Is marijuana as effective as the widely used and relatively inexpensive insulin sensitizer metformin? (Note that metformin is based on an extract from a plant.)
- How can marijuana be administered to the patient (smoked or ingested) to achieve the best effect against peripheral insulin resistance?
- Marijuana helps all people with insulin resistance?
- Do marijuana and other medications used to treat insulin resistance interact? If yes, how?
- How safe is marijuana use for people with peripheral insulin resistance and other coexisting diseases, such as cardiovascular disease, lung disease, and so on?
The present French study was not designed to answer these important questions.
However, robust and well-run clinical trials could be developed to provide accurate answers to these and other questions surrounding peripheral insulin resistance and the potential medicinal use of marijuana.
Such assays are likely to be expensive and time consuming to implement and eventually interpret the captured data.
However, by working with a physician, specifically an endocrinologist, making dietary changes, encouraging regular physical exercise, and taking the prescribed medication in a religious and critical manner, it would be possible to control and reduce peripheral insulin resistance and reduce , thus, the risk of diabetes type 2.
- The Diabetes Drill– Positive side
- Canadian survey compares marijuana use across different conditions– CATIE News
- About Diabetes- Canadian Diabetes Association
Diabetes - Health Canada
This information was provided by CATIE (Canada Exchange of AIDS treatment information). For more information, contact CATIE, 1.800.263.1638 or via email at Catie. The credit must appear on any online publication, with a link back to the original.
The translation into Brazilian Portuguese can not be used without the prior written authorization of those responsible for the Seropositive Web Site, subjecting the offender to the possible implications of the laws covering intellectual property rights. Note that in general, I will hardly deny the use of the text itself, provided the credits are given. However, exact replication of the page, making use of the images that I am forced to buy to maintain some originality and not fall into the sameness, I will not authorize. If you want to get good quality photos for surprisingly low prices, click on this link, which opens in another tab and on another site. Thank you
Translation adaptation and revision of the original in Canadian English to Portuguese of Brazil (it does not exist Brazil with "z" and "BraZil" is in the idiomatic aberration created for persons that only God knows why they do this and which obscure intention they may have ...) of the original in French study hints at marijuana's potential for Reducing diabetes risk by Claudio Souza