- Device similar to the contraceptive implant may "revolutionize" the Antiretroviral Therapy
- "Releasing" automatic antiretroviral drugs - that prevent HIV to replicate
- The current treatment requires a lot of attention and can complicate treatment adherence, because the therapy is usually prescribed with three different drugs to prevent the virus from becoming resistant
- Experts hope new implant could sit under the skin for up to 12 months
A new small-sized device can "revolutionize" the way people with HIV are treated, experts say.
The device, which is similar to contraceptive implant designed to be placed under the skin provides anti-retroviral drugs to patients.
Research has shown that strict compliance with the prescription of these drugs is vital in suppressing HIV. They work by preventing the virus from replicating in the body, allowing the immune system to repair themselves and help prevent any further damage.
They reduce the amount of HIV in a person's blood, their viral load to very low or undetectable level (in Brazil, in public, this limit is set at 40 copies of HIV); in some laboratories for more precise tests, ms have to get used to what we have.
With an undetectable viral load, HIV is not able to damage the immune system of the person.
This form of treatment can also be used as a means of preventing the spread of HIV.
Successful treatment plans against HIV are able, according to the study IPPERGAY still undergoing analysis, to avoid passing the virus to a sexual partner and, similarly, prevent the mother transmit HIV to her child during pregnancy or childbirth, the call transmission.
However, patients may have difficulty adhering to their prescriptions, usually juggling a complex number of different drugs with different doses to be followed for the smooth progress of the treatment.
Combination therapy, or cocktail, as it is known by the Brazilian population, typically involves a patient taking three antiretroviral drugs, because HIV can adapt to drugs in a process "monotrapia" with one drug (Translator's note. Combination therapy uses different drug class, and each class interferes with one of several stages of the HIV life cycle, _virtualmente make it impossible for the virus to replicate. It is this replication which arise resulting mutations that may be resilient and that it is free to I, and many others, have survived for more than a decade to HIV infection; this has required of us a draconian discipline when it comes to taking medication).
But scientists at Oak Crest California Institute of Science believe that his new invention can provide a more effective means of treatment of patients.
The device works by providing a controlled amount of antiretroviral drugs for a long period of time.
First tests in animals have shown no side effects over a period of days 40.
Study author and founder of Oak Crest Dr. Marc Baum, said:
"To our knowledge, this is the first implant to be used for this purpose. "
"This new device will revolutionize the way we treat or prevent HIV and AIDS, it provides a powerful scheme ART (Antiretroviral Therapy) not subject to errors, which eliminates a major obstacle to the prevention of the development of infection HIV AIDS, maintaining correct levels in the appropriate dosage of each of the complex HAART regimens. "
He said that doctors and scientists recognize that one of the main drawbacks of current treatments is the problem of patients to remain within very complex schemes of therapy, which can fail even because of "Social Pressure. (Translator's note, click the below link and see carefully to what can be a serious issue of medication adherence when it needs a dose at midday, in the hours: The right of AIDS (Original title of matter that opens at another site in another tab of your browser)
"It's unfortunate, but patients do not always follow the prescribed dosage instructions," he said.
"In clinical trials irregular intake of medicines led to the highly variable efficacy results.
"That's what struck our interest in the possible use of a subcutaneous implant for the prevention of HIV."
The implant, a small flexible tube measures about 40 mm long and is designed to be inserted under the skin by a health care professional.
Dr. Baum added, "Our subdermal implant is used just as a contraceptive implant.
"It is easily inserted and removed and provides sustained release of the powerful pro-drug tenofovir alafenamide.
"That's about 10 times more potent against HIV that tenofovir disoproxil fumarate - another prodrug which has been shown very effective in preventing HIV infection and STDs when used as a" PrEP agent. "
"We are delighted with the results of our preliminary studies and are working diligently to develop a subdermal implant HIV prevention that remain in force for a total of 12 months."
The findings of Dr. Baum's team were published in the journal Antimicrobial Agents and Chemotherapy.
Commenting on the revolutionary process, Dr Rosemary Gillespie, CEO of the Terrence Higgins Trust, "said:" administer antiretroviral medication through an implant is potentially an exciting new way to provide treatment for people living with HIV. "
"Currently, antiretroviral drugs must be taken daily and orally.
"We know that there are many situations that can lead to a patient ma-adhesion with respect to the medical dose, so that an implant could overcome this challenge. ".
He added: "But the most important thing to note here is that the effectiveness in humans remains to be tested with this implant."
Boot the Seropositive Editor Web Site: While this is not enough you need to find palliative and if you have a smartphone, or even a cell able to use Android in 2.2 version or higher and the same applies for IOS users if a user Iphone, you can click the web address that put forward. It leads to the page you can take if you decide so, the installation of a "App" which takes the place of a nurse / Desk, where you can enter all your medical schedule, from medicines, with the possibility of describing how to take as pills, tablets, drops or spoonfuls, for example, to its schedule ! You can register which doctor prescribed medication, assign them, and to you too, an avatar, email address and telephone number (if you get the miracle to get this information). Finally the application name is MEDSAFE and it would be ideal if you were logged in to your Google Account, to enjoy immediately the benefits that this application can saw aa offer.Here the link to the websiteof the application that helps us to maintain our well controlled therapy, being controlled, enough, with the help since implant and the observance of this treatment. It is important that each person becomes aware of the important role they can play in the treatment of another person's HIV