- Device similar to contraceptive implant can "revolutionize" Antiretroviral Therapy
- "Automatic" release of antiretroviral drugs - which prevent HIV from replicating
- Current treatment requires a lot of attention and can complicate ADHESION for treatment, since therapy is usually prescribed with three different drugs to prevent the virus from becoming resistant
- Experts hope new implant could sit under the skin for up to 12 months
A new small device can "revolutionize" the way HIV carriers are treated, experts say.
The device, which is similar to the contraceptive implant designed to be placed under the skin, provides antiretroviral drugs to patients.
Research has shown that strict adherence to the medical prescription of these medications is vital in suppressing HIV. They work by preventing the virus from replicating itself in the body, allowing the immune system to repair itself and help prevent any further damage.
They reduce the amount of HIV in the person's blood, their viral load to a very low or undetectable level (in Brazil, in the public network, this limit is set in 40 copies of HIV); in some laboratories there are more precise examinations, but we have to get used to what we have.
With an undetectable viral load, HIV is not capable of damaging the person's immune system.
This form of treatment can also be used as a means of preventing the spread of HIV.
Successful HIV treatment plans are able, according to the IPPERGAY study still in the analysis phase, to prevent transmission of the virus to a sexual partner and, in the same way, prevent the mother from transmitting HIV to the child during gestation or childbirth, the transmission.
However, patients may have difficulty adhering to their prescriptions, usually juggling a complex number of different medications, with several dosages to be followed for the proper course of treatment.
Combination therapy, or cocktail, as it is known by the Brazilian population, usually involves a patient taking three antiretrovirals, as HIV can adapt to drugs in a single-drug "monotrace" process. drugs of different classes, and each of these classes interferes in one of several stages of the HIV life cycle, make it virtually impossible for the virus to replicate. I, and many others, have survived HIV infection for more than a decade; this has required of us a draconian discipline in taking medications.
But scientists at the Oak Crest Institute of Science in California believe that their new invention may offer a more effective means of treating patients.
The device operates by delivering a controlled amount of antiretroviral drugs over a long period of time.
Early tests on animals have not revealed side effects over a period of 40 days.
Author of the study and founder of Oak Crest, Dr. Marc Baum, said:
"To our knowledge, this is the first implant to be used for this purpose. "
"This new device will revolutionize the way we treat or prevent the HIV virus and AIDS, as it provides a powerful non-error-prone Antiretroviral Therapy (ART) scheme that eliminates one of the major obstacles to preventing the progression of Infection to AIDS, while maintaining the correct dosage levels for each of the complex ART regimens. "
He said doctors and scientists recognize that one of the major drawbacks of current treatments is the patient's problem of staying within very complex therapy regimens, which can fail even on account of "Social Pressure. (Note from the translator, click on the link below and watch carefully what can be a serious problem of adherence to the medication when it needs a dose in the middle of the day, in the middle of the file: The right of AIDS (Original title of matter that opens at another site in another tab of your browser)
"It's unfortunate, but patients do not always follow the prescribed dosing instructions," he said.
"In clinical trials, irregular drug administration has led to highly variable efficacy.
"This is what has hit our interest in the possible use of a subcutaneous implant for HIV prevention."
The implant, a small flexible tube, measures about 40 mm in length and is designed to be inserted under the skin by a health professional.
Dr. Baum added: "Our subdermal implant is used in the same way as a contraceptive implant.
"It is easily inserted and removed and provides for sustained release of the potent pro-drug tenofovir alafenamide.
"This is about 10 times more potent against HIV than tenofovir disoproxil fumarate - another pro-drug that has been shown to be very effective in preventing HIV infection as STDs when used as a" PrEP agent. "
"We are very pleased with the results of our preliminary studies and are working diligently to develop a subdermal HIV prevention implant that will remain in effect for a total of 12 months."
The findings of Dr. Baum's team have been published in the journal Antimicrobial Agents and Chemotherapy.
Commenting on the revolutionary process, Dr. Rosman Gillespie, CEO of Terrence Higgins Trust, said: "Administering antiretroviral medication through an implant is potentially a new and exciting way to provide treatment for people living with HIV."
"Currently, antiretroviral drugs must be taken daily and orally.
"We know there are many situations that can lead a patient to over-adherence to medical posology, so that an implant could overcome this challenge. ".
He added, "But the most important thing to note here is that efficacy in humans continues to be tested with this implant."
Boot the Seropositive Editor Web Site: While this is not enough you need to find palliative and if you have a smartphone, or even a cell able to use Android in 2.2 version or higher and the same applies for IOS users if a user Iphone, you can click the web address that put forward. It leads to the page you can take if you decide so, the installation of a "App" which takes the place of a nurse / Desk, where you can enter all your medical schedule, from medicines, with the possibility of describing how to take as pills, tablets, drops or spoonfuls, for example, to its schedule ! You can register which doctor prescribed medication, assign them, and to you too, an avatar, email address and telephone number (if you get the miracle to get this information). Finally the application name is MEDSAFE and it would be ideal if you were logged in to your Google Account, to enjoy immediately the benefits that this application can saw aa offer.
Here the link to the website of the application that helps us to maintain our well controlled therapy, being controlled, enough, with the help since implant and the observance of this treatment.
It is important that each person becomes aware of the important role they can play in the treatment of another person's HIV