Two HIV-infected men going through a "spontaneous cure".
Scientists have discovered the phenomenal adaptation mechanism that apparently took two HIV-infected men to go through a "self-healing".
They say the finding may lead to new treatments for the disease caused by HIV, AIDS.
In this case, the two patients infected with HIV, and one of these individuals carries the AIDS virus there are at least thirty years , without ever developing any sign of advancing HIV infection in an AIDS case.
The change appears to be related to an increase in specific enzyme activity, known as APOBEC, and consistent with the theories espoused by the researchers.
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“The work opens therapeutic avenues for healing, using or stimulating this enzyme among newly infected patients who have a chance of spontaneous healing " said a statement.
The paper, published in the journal Clinical Microbiology and Infection, Was conducted by scientists from France's Institute of Health and Medical Research (Inserm).
HIV replicates after it invades the cells of the Immune System human CD4 and, after insert your genome into the CD4 cell genes by a process called Reverse Transcriptase, which, without realizing it, begins to create new copies of HIV until the cell ends up dying, which causes a spillage of new copies of HIV into the bloodstream. And these viruses go in search of new host cells to repeat the process. For some time the body is able to replenish the lost cells and then it begins to lose these battles and the CD4 count begins to fall and the person, without proper treatment, can develop AIDS (read the article Best Understanding the Disease - This link opens in another tab of your browser)
A very small group of people - less than 1% of people living with HIV - are naturally able to control viral replication and keep the virus at undetectable levels, clinically speaking.
They are known as "elite controllers" (click here to learn more about the lives of these people, "Elite controllers - This link also opens in another tab of your browser). But the mechanism by which they keep the virus under control still remains an unfathomable mystery.
The French group watched the two HIV carriers, a 57 year-old man diagnosed HIV positive in the mid 80 decade of the last century, and one with 23 years, who received his diagnosis in 2011, and was made sequencing the genome Viral both.
Although they have remained infected, their viral loads remain, though without being on ART (antiretroviral therapy) undetectable.
The staff found that in both cases, the virus was unable to replicate in cells of the immune system due to mutations in their genetic code.
A hypothesis was suggested that whenever a hypothesis, there is a spontaneous mechanism of evolution between humans and the virus, a process called "endogenization", where it is believed that the human DNA has neutralized HIV in our ancestors.
A similar process was observed in a population of koalas that have built a virus similar to AIDS in their genes, but they managed to resist and pass this resistance to their offspring.
“We propose that cure can occur by HIV in humans endogenization"Officially declared the team.
“These results suggest that without therapeutic and prophylactic strategies, after several decades of interaction between HIV and millions of deaths, it is likely that some people might neutralize and transmit that power neutralizer for their children"They added.
Researchers this genomic interaction is exactly the key to inactivating it and finding a cure for HIV infection thereby decreasing the end of AIDS even in people with AIDS pictures, from the study of the viral genome while interacting with the human genome.
Although the two patients presented in the study had the controlled levels of HIV in the blood, other patients have already been considered cured.
Timothy Ray Brown, is considered the first to have been cured after receiving a bone marrow transplant in a treatment against leukemia. The bone marrow donor is believed to have transmitted its resistance to HIV.
In another study, a Mississippi-born baby who was born with HIV received antiretroviral drugs for 18 months after birth and was declared cured and yet, unhappily, HIV returned to reappear in the girl's body some time later.
Soropositivo.org editor Notes: Although the source I used not clarify a few points, I left, inset of the text, some links I would suggest that you clicked. I recall that until recently I envy (envy white) elite controllers; I do not envy more. This was because I found a story that already It is this site and the link is just above, which shows how difficult the life of an elite controller is, and I find it hard to believe that the two patients used as examples in this study can be considered elite controllers, given the volume of suffering, the number of hospital admissions , the status of elite controller is that of a person who lives much longer in the state of Immune Response (a humoral response state that always consists of inflammatory responses such as low-grade pain, constant pain and everything that involves the immune response itself that you see in the following video (The text proceeds after the video and you are entirely free to ignore it, but you will fail to learn very interesting things about how to your body works and how much the life of a Elite Controller... (...) ...
I can not disbelieve in the possibility of adapting the human organism to the presence of HIV and not even of a "viral initiative" that seeks a balance relation with the host organism. So it is in cases of Feline AIDS, caused by FIV (Feline immunodeficiency virus which in English would be IVF); however, at least in the case of felines, this was at least a secular process and I can not from my modest point of view see how globally a "forced evolution"In the human genome without breaking a few cups (human lives) ... Is this acceptable from an ethical / moral point of view? In what way?
I do not know. However I know that someone will say that if it is necessary to save mankind, it is lawful to select a few million (!!!) [@:] to give continuity to the human species.
And I ask again: And who would these "elect" be? Who can afford it? Or would there be a selection for casual servants? I do not know.
What I do know is that this is a matter of other issues. Although I want to feel my heart full of hope, I always remember Leviathan and the old maxim that claims to be the Man the true wolf of man
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