APOBEC Enzyme Can Make HIV Co-inhabit with the Human Organism

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Two HIV-infected men undergoing a “spontaneous cure”.

The scientists discovered the phenomenal adaptation mechanism that apparently led two HIV-infected men to undergo a "spontaneous cure".

They say the finding could lead to new treatments for HIV disease, AIDS.

In this case, the two HIV-infected patients, and one of these individuals carries the AIDS virus at least thirty years ago , without ever developing any signs of advancing HIV infection for an AIDS case.

The virus still exists in the cells CD4 (The most important Immune system and that they are the main target of the AIDS virus) and, however, it was inactivated because its genome had changed, as the researchers say.

The change seems to be related to an increase in the activity of a certain enzyme, known as APOBEC, and, in line with the theories espoused by the researchers.

The "spontaneous cure" has caused "great uproar" among scholars in pharmacodynamics who work with the development of new drugs; one of them says the following

"The work opens therapeutic paths for a cure, using or stimulating this enzyme among newly infected patients who have a chance of spontaneous cure ”, said a statement.

The paper, published in the journal Clinical Microbiology and Infection, was carried out by scientists from France's Institute of Health and Medical Research (Inserm).

HIV replicates after invading the cells of the Immune system human CD4 and, after insert your genome into the CD4 cell genes by a process called Reverse Transcriptase, which, without realizing it, begins to create new copies of HIV until the cell ends up dying, which causes a spill of new copies of HIV into the bloodstream. And these viruses go in search of new host cells to repeat the process. For a while the body can replace the lost cells, and then it starts losing these battles and the CD4 count starts to drop and the person, without proper treatment, can develop AIDS (read the article Better Understanding the Disease - This link opens in another tab of your browser)

A very small group of people - less than 1% of HIV-positive people - are naturally able to control viral replication and keep the virus at undetectable levels, medically speaking.

They are known as “elite controllers” (click here to learn more about the lives of these people, the “Elite controllers - This link also opens in another tab of your browser). But the mechanism by which they keep the virus under control remains an unfathomable mystery.

The French group observed the two HIV carriers, a 57-year-old man diagnosed HIV positive in the mid-80s of the last century, and a 23-year-old man who received his diagnosis in 2011, and the genome was sequenced viral of both.

Although they have remained infected, their viral loads continue, although without being on undetectable ART (antiretroviral therapy).

The team found that in both cases, the virus was unable to replicate itself in cells of the immune system due to mutations in its genetic code.

A hypothesis was suggested in which, always a hypothesis, there is a spontaneous evolution mechanism between humans and the virus, in a process called “endogenization”, where it is believed that human DNA has neutralized HIV in our ancestors.

A similar process has been observed in a koala population that has integrated an AIDS-like virus into their genes, but they have managed to resist and pass that resistance on to their descendants.

"We propose that the cure for HIV can occur through endogenization in humans“, The team officially declared.

"These results suggest that, without therapeutic and prophylactic strategies, after several decades of interaction between HIV and millions of deaths, it is likely that some people can neutralize and transmit this neutralizing power to their children.”, They added.

Researchers believe that genomic interaction is exactly the key to inactivating it and finding a cure for HIV infection, thus decreeing the end of AIDS even in people with AIDS pictures, from the study of the viral genome while interacting with the human genome.

Although the two patients presented in the research have controlled levels of HIV in the blood, other patients have already been considered cured.

Timothy Ray Brown, is considered the first to have been cured, after receiving a bone marrow transplant, in a treatment against leukemia. The marrow donor is believed to have transmitted his resistance to HIV.

In another study, a Mississippi baby who was born with HIV received antiretroviral drugs for 18 months after birth and was declared cured, but unfortunately, HIV returned to the girl's body some time later.

Notes from the editor of seropositivo.org: Although the font I used does not clarify some points, I left, in the middle of the text, some links that I would suggest you to click. I remember that until very recently I envied (white envy) the elite controllers; I don't envy you anymore. This happened because I found a story, which is on this site and the link is just above, which shows how difficult the life of an elite controller is and I find it hard to believe that the two patients used as an example in this study can be considered elite controllers, given the volume of suffering, the number more hospital admissions , the status of elite controller is that of a person who lives much longer in a state of Immune Response (a state of humoral response that is always composed of inflammatory responses, such as fever, constant pain and everything that involves the immune response itself that you see in the following video (The text continues after the video and you are entirely free to ignore it, but you will stop learning very interesting things about how your body works and how much the life of a Elite Controller… (…)…

I do not go so far as to disbelieve the possibility of adapting the human organism to presence of HIV and not even a “viral initiative” that seeks a balanced relationship with the host organism. So it is in cases of Feline AIDS, caused by VIF (Feline immunodeficiency virus which, in English would be FIV); however, at least in the case of felines, this was at least a secular process and I cannot, from my modest point of view, see how to make a global “forced evolution”In the human genome without breaking some bowls (human lives)… Is this acceptable from an ethical / moral point of view? In what way?

I do not know. However, I know someone will say that if it is necessary to save humanity, it is permissible to select a few million (!!!) [@:] to continue the human species.

And I ask again: And who would these "elect" be? Those who can afford it? Or would there also be a selection for casual servants? I do not know.

What I do know is that this is an issue pregnant with other issues. Although I want to feel my heart full of hope, I always remember Leviathan and the old maxim that Man the true wolf of man

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