Drugs for cholesterol can provide benefits in patients with candidemia

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candidiasisStatins to manage high cholesterol in people at risk for cardiovascular disease can also reduce short-term mortality among people with fungal infections CândidaPerhaps due to its immunomodulatory properties, according to a study presented at 52ª Inter Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC to 2012) this week in San Francisco.

This retrospective cohort study analyzed more than 400 hospitalized patients with candidemia (Candida infection in the bloodstream), 14% of whom were taking statins. Nevertheless people on statins with more comorbidities associated with health and statin and not of equivalent statin in patients who received antifungal therapy, those taking statins had significantly lower mortality rate in 5 days (5 7% vs% respectively ). However, 2 groups had similar ratesCândidapersistence, stability 48 hours and the mortality 30 days.

Below is an excerpt from a press office ICAAC edition describing the findings in more detail.

Candidaemia is a leading cause of complications and death in hospitalized patients. It has been suggested that the use of hydroxymethylglutaryl-CoA reductase inhibitors, also known as statins, be the drug of choice for treating dyslipidemias, may have a beneficial effect on the outcome of patients with infections. The statins have anti-inflammatory properties, anticoagulants and antioxidants that are thought to have beneficial effects during sepsis. Furthermore, statins have intrinsic You determine activity against strains of Candida.

A multidisciplinary team led by Professor Cuervo which included specialists in infectious diseases and microbiology six hospitals in Spain, Brazil and Argentina have carried out research with the hypothesis that statins could improve the outcomes of adult patients with candidemia. The study results will be presented at the Interscience Conference on 52ª antimicrobial agents and chemotherapy to 2012 meeting in San Francisco on September 9.

Cuervo et al. They showed that patients on statins were older and often had chronic cardiovascular diseases.Candida albicansIt is the most common species, followed byC. parapsilosis, C. tropicalis, C. glabrataandC.krusei.

Although patients recebifo similar antifungal treatments and whose disease severity, were equivalent, those on statins had lower early mortality rate (5º day). This effect was not seen with other cardiovascular drugs (aspirin, beta blockers and ACE inhibitors). In general (30 days) mortality rates were similar between groups.

The results were equivalent in most severely immunosuppressed patients. Those with neutropenia were excluded. Translator's note: Neutropenia is small amount of neutrophils in the blood.

These results suggest that statins can have a beneficial effect on the outcomes of patients with candidemia. This hypothesis deserves to be evaluated in prospective studies.

Translated from original2012 ICAAC: Statins Are Beneficial for Patients with Candida Fungal Infections?by Claudio Souza; reviewed by Mara Macedo

References

G Cuervo, C Garcia-Vidal, Nucci M, et al. Effect of Statin Use on the Outcomes of Adults with Candidemia. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012). San Francisco. September 9-12, 2012.Abstract M-329.

Other Source

ICAAC / American Society for Microbiology. Drugs for Cholesterol Control Could Provide Benefits in Patients with Candidemia. Press release. September 9, 2012.

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