Altered cholesterol metabolism appears to protect cells of the immune system from HIV-positive individuals "no long-term progressors"
Cholesterol metabolism improved in certain cells of the immune system may help explain why some people with HIV can naturally control the virus with little or no disease progression, according to research presented at 8ª International AIDS Society conference on pathogenesis treatment and HIV prevention in search for a cure, last month in Vancouver. The results suggest that the regulation of cellular cholesterol metabolism may offer a novel approach to controlling HIV and potentially reach a functional cure or long-term remission.
Giovanna Rappocciolo the University of Pittsburgh and colleagues performed a presenting laboratory analysis comparing cell - dendritic cells and B cells that capture invading viruses and display it for recognition by T cells from HIV-positive people with progression of the typical disease and non-progressors, or individuals whose disease does not progress for years, even without antiretroviral therapy.
Researchers previously reported that presenting cells from non-progressing individuals are inefficient in transfection or are ineffective transferors of the virus intact to T cells. Presenting cells from non-progressing individuals have shown transinfection before and after the primary HIV infection, while cells of common progressors showed normal trans infection. They hypothesized that the difference probably had a genetic basis.
Translator's note. Iron and fire the entry transifection It is well defined in Wikitionary: Transinfection (plural transinfections) (the biology of infection) from a host (the act of infecting one) with a bacterium or virus of another type, often with microinjection, in order to study the different roles of hosts and infected species often used to describe DNA import transfer mediated infection, which is what occurs within one of the HIV "invasion" processes in CD4 cells click here to see the HIV lifecycle
In a poster presented at the IAS, Rappocciolo and colleagues reported that a genetic analysis has shown that transfection is affected and appears to be due to the advanced cholesterol metabolism within the presenting cells of non-progressing individuals, leaving them with extremely high cholesterol levels low.
Specifically, they performed a transcription analysis of the entire genome in dendritic cells, B cells and CD4 T cells from 8 non-progressors and 8 typical progressors in the Multicenter AIDS Cohort Study (MACS) .. A long-term study of the natural history of the disease by HIV or AIDS treated and untreated in men who have sex with men looking for differences in the expression of genes related to cholesterol metabolism.
They note that the "presenting cells" of non-progressing individuals express several genes related to cholesterol metabolism pathways compared to typical progressors.
We found that presenting cells of individuals non-progressors a complete lack of ability to transinfectar of T-cells, the researchers concluded. This was associated with cholesterol metabolism which appears to be deeply improved hereditary, and identify genes involved in the uptake, trafficking and metabolism of cholesterol that are associated with the phenotype of lack of cross infection.
These results, added, provide a basis for therapeutic interventions for the control of HIV-infection 1 through modulation of cholesterol metabolism.
Translated by Claudio Souza reviewed by Mara Macedo the original IAS 2015: Altered Cholesterol Metabolism May Protect Immune Cells of Non-progressors
Observation of Soropositivo.Org Editor: This is all very promising and, as a friend says, it is too early to celebrate is a cure. There is a possibility and I believe that this may be a way to find, for example, a long-term treatment with, for example, a Picula HIV each month, perhaps every one year, do not.
But, as the day Beatriz PachecoEveryone connected adherence to get forms and strong to this day functional cure, remitting or complete!
G Rappocciolo, J Martinson, P Piazza, et al. Profound alterations in cholesterol metabolism restrict HIV-1 tranny infection of CD4 T cells in nonprogressors. 8th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention. Vancouver, July 19-22, 2015. Abstract MOPEA013.
National Institute of Allergy and Infectious Diseases. Cholesterol Metabolism in Immune Cells Linked to HIV Progression. Press release. July 17, 2015.