Despite treatment HIV grows silently
HIV can continue to grow in patients who think they are responding well to treatment, according to research from the University of Liverpool.
During the treatment of hides HIV in blood cells called lymphocytes T CD4 that are responsible for immune response of the patient inserting his own genetic information in the DNA of cells CD4.
A study conducted by the University's Institute of Infection and Global Health measuring levels of HIV integrated into CD4 cells of patients undergoing continuous treatment for up to 14 years, comparing thus patients treated for different lengths of time. The researchers found that the amount of HIV was found and integrated into CD4 cells was not decreased at all since p 1º year of treatment even in patients with a treatment window of up to 14 years.
Research shows that whenever a CD4 cell multiplies to produce more cells, it makes a copy of itself and also copy the HIV genes. This process - a kind of silent replication of HIV, the virus means no need to copy, produce new virus particles and infect new cells CD4 - but is automatically incorporated into the birth of the newly created cell.
Antiretroviral therapy is given to patients with HIV to stop the production of new virus to prevent infection and death of T lymphocytes and CD4 disease progression.
Advances in antiretroviral therapy over the past 30 years, mean that most patients can have their virus suppressed to undetectable levels and live a long and healthy life. If it thought that, after many years of successful treatment, the body would be able to purge themselves of the virus itself.
Hard to suppress
Professor Anna Maria Geretti, who led the study, said: "This research shows that unfortunately the HIV virus found another way out of our treatments.
"We always knew HIV is difficult to completely suppress, and that he hides inside CD4 cells, but always hoped that the body gradually renew their CD4 cells and then HIV would have a hidden death. We were surprised to find that levels of HIV integrated into CD4 cells can not be reduced even over a period of 14 years.
"The good news is that we do not see any worsening over time; unfortunately the bad news is that these findings really cast doubt on the question of whether HIV can be "cured" by simplesmte improve immune responses against him - a strategy that now seems doomed to failure. "
The results are published in the journalBiomedicine.