Many research teams are looking for ways to slow down the aging process, both in HIV-positive patients and in HIV-negative individuals. So far there are no proven methods for actually reversing aging (despite what TVTL savvy advertisers put out on TV and on the Internet stating they can). Here is a sample of some of the most promising examples of slow aging research, and a few examples of people in whom these "tactics" may be more risky and require caution.
As already explained, the chronically active immune system is harmful in many ways. Not only it can directly damage our blood vessels and vital organs, but can also accelerate the turnover of our immune cells, leading to develop immunosenescence related to age.
A wide variety of compounds currently available for other conditions and other-experimental are being tested in people with HIV to calm the immune system. Among the drugs under study are aspirin, HMG-CoA reductase inhibitors (commonly called "statins" and used to lower cholesterol), protease inhibitor entry ( Selzentry maraviroc), and drugs that are commonly used to treat malaria. Experimental drugs include those that have been designed to treat arthritis and other inflammatory diseases.
Lengthening Telomeres and repair
In case of damage or shortened telomeres leading to immune exhaustion, then we should be struggling to repair or lengthen them, right? The best answer to that question is yes, but only if we can do it safely. There is a good reason to have evolved such that our telomeres decreased if a cell plays back: consiguem cells that do not stop the replication become carcinogenic. Drugs that stimulate telomerase enzyme, which helps maintain telomeres could hypothetically increasing the risk of certain cancers. There are some promising drugs in the early animal studies, but a great job of research will be needed before they are ready for the first time.
One of the most written and the methods of animal life cycle of stretching and (hopefully) the people is extreme calorie restriction. Studies have progressed from insects to small mammals and so far, it seems that a diet containing about half the "ideal" amount of calories for a given animal can significantly extend the life of the animal and increase their health and vitality during these additional years of life. We are very far from being able to study this method in humans, however, and most researchers and health care providers do not recommend that people with HIV start super-diets low in calories.
Another common treatment in "clinics and longevity" in the United States is the use of hormones like testosterone, human growth hormone and anabolic steroids. While each of these has been approved to treat common muscle and fat loss in people with advanced HIV disease (wasting syndrome), none of them is approved to slow down or reverse the aging process and all come with side effects that can actually increase some related to age, such as cardiovascular disease, liver problems and diabetes.
Some Final Thoughts on HIV / AIDS and aging
Potent combination ARV is not perfect and all available treatments can cause some side effects, the drug must be taken regularly almost perfect for the rest of his life; or it may stop working. That said, many experts agree that a person getting ARVs early enough have a great chance to live an almost normal life. The big question for many, then, is whether people with HIV to be able to stay healthy during the course of his old age?
Current research is trying to answer that question. Although rates of age-related diseases are much higher in people with HIV, it does not mean that those who are HIV positive will incur multiple diseases by the time they arrive at the 50 years. In fact, the actual rates of certain age-related diseases are still well below the 10 percent of people with HIV. What it is not yet clear and will be at increased risk of diseases, such as guards have to be screened in various diseases and the treatment of any diseases, have a need to be different in people with HIV.
Researchers are actively working on these issues. However, the best methods available for preventing age-related, physical and mental decline are the old standbys hot: diet, exercise, maintaining social connections and abstain from harmful behaviors.
Translated from Original in Are there experimental treatments to slow aging in people with HIV? by Cláudio Souza on 12 in September of 2016