People are infected with HIV are more likely than HIV-negative individuals suffer heart attacks, develop kidney disease and cancers unrelated to AIDS in the age of highly effective antiretroviral therapy, but do so around the same age, on average, According to a study of US veterans published in DOS.October 30 edition ofClinical Infectious Diseases
Several observational studies have shown that people with HIV experimental age-related conditions, such as cardiovascular disease, liver and kidney disease, and malignant diseases unrelated to AIDS more often than their HIV-negative counterparts. However, it remains unclear if these conditions occur earlier, suggesting that HIV infection promotes accelerated aging.
Keri Althoff Johns Hopkins Bloomberg School of Public Health and his colleagues compared the risk for diseases and conditions associated with 3º age such as myocardial infarction (MI), end-stage renal disease, and cancers not defining or related to AIDS - and ages at which they occur in HIV-positive patients and negative adults.
The researchers used a cohort study of data from the veterans and aging, a prospective study of HIV-positive patients and demographically infected matched US veterans, collected in the period April 2003 the December 2010, after the widespread availability of antiretroviral treatment. The analysis included data from 98.687 full participants mostly male, about a third of whom were living with HIV. During this period occurred 689 Myocardial infarctions, 1135 cases of kidney disease, and 4179 diagnosis of cancers unrelated to AIDS.
HIV positive patients participating adults were at increased risk for all 3 results compared to HIV-negative after adjusting for confounders. However, the average age to have a heart attack or unrelated cancer development AIDS do not differ according to HIV status, and the average age of diagnosed HIV-positive people with kidney disease were only 5,5 months under negative people.
"Adults infected with HIV had a higher risk in these age groups of associated events, but they occurred at similar ages [as] people without HIV," the study authors concluded.
Below is an excerpt from an editionJohns Hopkins press releasedescribing the study and its findings in more detail.
HIV-infected adults diagnosed with Age-Related Eye Disease Study diseases with similar ages and withers adults
The treatments are successful helping people infected with HIV to achieve similar longevity as those without HIV
11 2014 OF NOVEMBER - new research and studies from the Johns Hopkins School of Public Health Bloomberg suggests that HIV-infected adults are at increased risk of developing heart problems, kidney failure and cancer. But contrary to what many believed, the researchers say that these diseases are occurring at similar ages, adults who are not infected with HIV.
The results appeared online last month in the journalClinical Infectious Diseases.
According to the researchers, these findings may help reassure HIV-infected patients and their health care providers.
"We found no conclusive evidence to suggest that screening for these diseases should occur at an earlier age in HIV-positive patients compared with uninfected adults," says Keri N. Althoff, PhD, MPH, an assistant professor in the Department of Epidemiology at Bloomberg School and author of the study.
Using data from 98.687 HIV-infected patients and uninfected adults in the group of war veterans, a 1º cohort Aging Study April 2003 of 31 December 2010, the researchers were able to compare the ages at which each group was diagnosed with heart attack, kidney failure, and cancers unrelated to AIDS. Althoff and his colleagues found that HIV-infected adults have been diagnosed with kidney failure, on average, when they were six months younger than the group without HIV. There was no statistically significant difference in age at diagnosis differences between infected and uninfected individuals among adults for heart attacks or cancers unrelated to AIDS.
The study also compared the risk of age-related disease in HIV-infected and uninfected adults. Similar to previous studies, HIV-infected adults appear to be at increased risk of disease but the magnitude of increase in the risk was lower than has been reported in many previous studies, probably due to this study, adjustment capability for factors such as race, sex, obesity, smoking, diabetes, depression, among others, that influence the risk of both adult HIV-infected and uninfected.
In the early years of the AIDS epidemic, HIV was a death sentence. But in recent years antiretroviral therapy (ART) has been quite effective in suppressing viral replication of HIV and increased longevity for people living with HIV. A study published in December 2013, the US AIDS Cohort Collaboration Research and Design (NA-ACCORD) shows that the life expectancy of HIV-infected adults is just a few years unless the general population USA.
While people with HIV are living longer, there has been a contentious debate in medical circles about whether they are going through an accelerated aging process. People living with HIV have required more rigorous study of whether and why this might be happening.
Just because the data shows that the appearance of these three diseases are similar among those with and without HIV infection does not mean those with HIV are as healthy, Althoff warnings.
"Many HIV-infected adults feel older than their age," she says. "Our study examines three major age-related diseases and we found no significant difference in age at diagnosis. But this is not the whole story. We need more research to find out what is happening. "
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KN Althoff, KA McGinnis, CM Wyatt, AC justice, et al. Risk comparison and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining of cancer in HIV-infected adults vs withers.Clinical picture Infectious Diseases. 30 2014 OF OCTOBER (Epub ahead of print).
The Johns Hopkins Bloomberg School of Public Health. HIV-infected adults diagnosed with Age-Related Eye Disease Study diseases with similar ages as adults withers.Press release11 2014 OF NOVEMBER.