People are infected with HIV are more likely than HIV-negative individuals suffer heart attacks, develop kidney disease and cancers unrelated to AIDS in the age of highly effective antiretroviral therapy, but do so around the same age, on average, According to a study of US veterans published in DOS.October 30 edition ofClinical Infectious Diseases
Several observational studies have shown that people with HIV experimental age-related conditions, such as cardiovascular disease, liver and kidney disease, and malignant diseases unrelated to AIDS more often than their HIV-negative counterparts. However, it remains unclear if these conditions occur earlier, suggesting that HIV infection promotes accelerated aging.
Keri Althoff Johns Hopkins Bloomberg School of Public Health and his colleagues compared the risk for diseases and conditions associated with 3º age such as myocardial infarction (MI), end-stage renal disease, and cancers not defining or related to AIDS - and ages at which they occur in HIV-positive patients and negative adults.
The researchers used a cohort study of data from the veterans and aging, a prospective study of HIV-positive patients and demographically infected matched US veterans, collected in the period April 2003 the December 2010, after the widespread availability of antiretroviral treatment. The analysis included data from 98.687 full participants mostly male, about a third of whom were living with HIV. During this period occurred 689 Myocardial infarctions, 1135 cases of kidney disease, and 4179 diagnosis of cancers unrelated to AIDS.
HIV positive patients participating adults were at increased risk for all 3 results compared to HIV-negative after adjusting for confounders. However, the average age to have a heart attack or unrelated cancer development AIDS do not differ according to HIV status, and the average age of diagnosed HIV-positive people with kidney disease were only 5,5 months under negative people.
"Adults infected with HIV had a higher risk in these age groups of associated events, but they occurred at similar ages [as] people without HIV," the study authors concluded.
Below is an excerpt from an editionJohns Hopkins press releasedescribing the study and its findings in more detail.
HIV-infected adults diagnosed with Age-Related Eye Disease Study diseases with similar ages and withers adults
The treatments are successful helping people infected with HIV to achieve similar longevity as those without HIV
11 2014 OF NOVEMBER - new research and studies from the Johns Hopkins School of Public Health Bloomberg suggests that HIV-infected adults are at increased risk of developing heart problems, kidney failure and cancer. But contrary to what many believed, the researchers say that these diseases are occurring at similar ages, adults who are not infected with HIV.The results appeared online last month in the journalClinical Infectious Diseases. According to the researchers, these results can help reassure HIV-infected patients and their health care providers. "We found no conclusive evidence to suggest that screening for these diseases should occur at earlier ages in HIV-positive patients compared to uninfected adults," says Keri N. Althoff, PhD, MPH, an assistant professor in the Department of Epidemiology at Bloomberg School and author of the study. Using data from 98.687 adult HIV-infected and uninfected patients in the war veterans group, in an 1 April 2003, 31, December 2010 cohort study, researchers were able to compare the ages at which each group was diagnosed with heart attack, kidney failure, and non-AIDS cancers. Althoff and his colleagues found that HIV-infected adults were diagnosed with kidney failure on average when they were six months younger than the non-HIV group. There was no statistically significant difference in age differences at diagnosis between infected and uninfected adults among adults for non-AIDS-related heart attacks or cancers. The study also compared the risk of age-related diseases in HIV-infected and uninfected adults. Similar to previous studies, HIV-infected adults appear to be at increased risk for disease, but the magnitude of the increased risk was lower than has been reported in many of the earlier studies, probably because of this study, with adjustment capacity for factors such as obesity, smoking, diabetes, depression, among others, that influence the risk of both HIV-infected and uninfected adult patients. In the early years of the AIDS epidemic, HIV was a death sentence. But in recent years antiretroviral therapy (ART) has proven to be quite effective in suppressing HIV viral replication and increasing longevity for people living with HIV. A study published in December of 2013, the American AIDS Cohort Collaboration Research and Design (NA-ACCORD) shows that the life expectancy of HIV-infected adults is only a few years less than the general US population. At the same time that HIV-infected people are living longer, there has been a contentious debate in medical circles about whether they are undergoing an accelerated aging process. People living with HIV have required more rigorous study of whether and why this may be happening. Just because the data show that the onset of these three diseases is similar between those with and without HIV infection does not mean those with HIV are so healthy, Althoff warns. "Many HIV-infected adults feel older than their age," she says. "Our study examines three important age-related diseases and found no significant age difference at the time of diagnosis. But this is not the whole story. We need more research to find out what's going on. "
KN Althoff, KA McGinnis, CM Wyatt, AC justice, et al. Risk comparison and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining of cancer in HIV-infected adults vs withers.Clinical picture Infectious Diseases. 30 2014 OF OCTOBER (Epub ahead of print).
The Johns Hopkins Bloomberg School of Public Health. HIV-infected adults diagnosed with Age-Related Eye Disease Study diseases with similar ages as adults withers.Press release11 2014 OF NOVEMBER.