Educators often explain what happens in the body of people with HIV as a battle: the war between the virus and immune cells. Although too simple, this is truly the description / situation. HIV is not the only one with respect to this point, however. The immune system is constantly "war" with a number of harmful organisms, for example, viruses and bacteria which enter our bodies and our own cells that become defective and begin to reproduce very rapidly - what we call cancer.
Where HIV differs from many diseases is that in 99 percent of HIV-positive patients the immune system fails to control the virus very well. This constant battle state, where the virus reproduces and the body fights against it, keeps the immune system on high alert chronically, a so-called inflammation syndrome.
Inflammation is not intrinsically evil and that is something that we need to fight infections such as avian flu, to repair the damage to body tissues and prevent the growth of certain cancers, but unchecked inflammation can cause absolute chaos on the body, causing the accumulation of risks of heart attack and stroke, causing plaque in our arteries, feeding the growth of some cancers, and burning capabilities of our immune system.
We know, from the early years of the epidemic, the immune systems of people with HIV are chronically inflamed, but before the introduction of combination highly active antiretroviral therapy (HAART) in the late 1990, most people with HIV died too young and too fast for the long-term consequences of inflammation could be known. Since HAART became available, and people began to live longer, scientists were finally able to study the long-term effects of inflammation in people living with HIV.
In the last decade, Several studies produced some important results. We know that inflammation is significantly reduced in people who are able to get and keep their viral loads undetectable using ART. This is one reason why the committee responsible for writing the treatment guidelines for HIV Department of Health and Human Services (DHHS) recommends that people start therapy against HIV earlier. Unfortunately, we have also learned that an undetectable viral load does not mean that the inflammation is completely blocked, which can still be detected, and can cause problems in people who, otherwise, would be responding well to treatment with ART.
While researchers are concerned with how inflammation directly affects major organs such as the heart, the liver13 and kidneys, they are also interested in how chronic inflammation affects the immune system itself. The longer the person's immune system continues to fight HIV - even if ART is being used, the more likely that person can experience immunosenescence age-related, sometimes also called This condition means "immune exhaustion." that immune cells can not react appropriately when faced with a new challenge. They also do not reproduce easily and efficiently. In fact, when scientists have immune cells of people with HIV, they find that these cells often have the same degree of wear, the cells of HIV negative people decades older ...