Cure for HIV is not there in front around the corner ... But there is hope!

Cut through the hype and hyperbole.

There is much to be done in the field of scientific advances until they find a cure for AIDS

I, Cláudio Santos de Souza, since this video, knowing that the person responsible for his placement can prevent it from being displayed here.

Before proceeding I ask what is the suit of "activist" who hides behind an avatar?

I know and respect (some I love) many activists. And not all I know personally. But I saw their faces, dozens of times, on facebook, twitter, Instagram, on their personal websites and more importantly, I know their names!

You need to think you can trust someone who "fight for you", but hiding in the anonymity of a "nickname" and an avatar. Because that's all we know, the summary of summaries ...

If you do not see the video here you will find the link to it at the end of this introduction.

I recommend you to watch this video carefully and a certain amount of skepticism. This video gave rise to the text that I translated below, which should be read carefully.

I consider at least a reckless action spread this video, which makes people think about things they can change their sexual behavior when it comes to safety in relations, leading to a considerable increase, and even tragic AIDS cases throughout the planet as a result fatal to humans, victims of people without regard for human life!

The video has given rise to this text and I suggest that you read carefully with eyes and reasoning. They are trying to make us believe something that might not be realized. I work for almost seventeen years with this site and I take very, very careful what you publish, because I know I deal directly with public health involving human lives.

If the video is not here look for in YOUTUBE (the link opens in another tab to the right of the one you are in now). I do not disregard the idea of ​​being relocated to another URL, and maybe you can find it looking for this expression:

as I predicted, the incorporamento was blocked. For those interested in joining ...

But ... The video is there! And below it, the response of the scientific community

If you do not find, warn me, for then I will know that I have been able to remove it. :) and I will put it back to warn about this kind of irresponsibility, like a lighthouse on the cliffs, with a light so strong that no fog can overshadow.

Claudio Souza. Seropositive since 1994.
Claudio Souza. Seropositive since 1994.

Liver - Female Organs - Human AnatomyThe news in April 2013. The Danish researchers said was a matter of "mere months" (it opens in another flap and I was also one of those who fell on the hopeful news) to find a cure for HIV. Other media eagerly took up the electrifying report, and the words crossed the planet in online newspapers, and after that, of course, they reached social media, which fostered the idea that it was a matter of waiting (p.ara it has been a matter of waiting there twenty-two years) to talk about "an end to the HIV / AIDS epidemic, and that this could happen soon, becoming a reality."

There was a difficulty: the UK surprisingly placed on the first page of a newspaper, "Scientists on the Verge of cure of HIV infection."

It was not true. Researchers at the University of Aarhus Hospital in Aarhus, Denmark, were and are still researching a cure for HIV. A Danish scientist who is investigating an anti-cancer known as histological deacetylase (HDAC inhibitors) as a means of flushing the virus from the so-called "latent reservoir where he (HIV) hides, evading antiretroviral treatment (ART). But at Aarhus University research is just one of the early stages of the processes several years before testing in humans. And there is no guarantee that researchers are no more than scratch the surface of the arduous task of finding a cure for the widely complex process of viral infection such as HIV infection.

The Telegraph, which eventually revised the article online, while the hospital launched its own correction, were practically alone in the request, or at least implying that a cure of the infection for HIV infection would be imminent. Not only is the health of HIV concern that inspired this wrong hyperbole. Since President Richard Nixon announced the "war on cancer" in 1971, with news they have repeatedly raised the hopes of the great victory ahead.

Usually an enticing headline related to HIV comes from medical sites daily, as those in March 2015, get excited to say that a functional cure for the virus is not completely eliminated from the body but is under control without ARVs was a step closer to reality.

However, Michael Farzan, PhD, a prominent researcher of curing HIV infection, a professor at Scripps Research Institute in Florida, says, "It's hard to say how far we are from start to finish" in the search for a cure for HIV. "Who knows; we could have moved in an inch in a march of 100 miles. "

Zhi Hong, Ph.D., chief research in infectious diseases GSK (GlaxoSmithKline), which is one of several pharmaceutical companies to invest in curing research, puts the issue in a more definitive way: "There is no illusion that [the cure] can still cost a monumental investment of money and decades to come to fruition."

Zealous members of the media are practically the only ones contributing to misperceptions about curing public research. Perhaps unintentionally-his words ran contrary to all other public messages from his foundation focused on global health and Microsoft founder Bill Gates told participants at the World Economic Forum in January that both an HIV vaccine and the means to avoid that people living with HIV have the need to take ARVs daily would reach 2030.

Richard Nova Lima, an expert by the search for a vaccine and cure against HIV in Action Treatment Group, said in a post on the TAG website, expressed the following reasoning:

"Hope does not equal inevitability."

Regarding the enthusiasm of Gates, New Lima wrote, "have no scientific basis; there were encouraging signs of progress on the vaccine and cure on some fronts in recent years - but the challenges that lie ahead should not be underestimated

Then there is a lush and hyperbolic amount of messages from amfAR Foundation to raise funds for the fight against AIDS, for research on AIDS, which sends frequent emails signed by CEO Kevin Frost in which he characterizes non-profit organization for the countdown of the "cure", a self initiative as outlined devoted to "end unlocking the mysteries of HIV" or clearing the "final obstacles" that are still blocking a cure for HIV infection.

A video of amfAR's extremely high merchandising concept in April states that the fight against HIV has made it "the final mile of an epic journey," and that "healing for all is near. The end of the Journey is finally in sight. All we need to do is grab the torch and touch the finish line. "Only at the end of the 1.000 words of the promotional text amfAR stands as the pivot of the respective achievement repeatedly stressed that the purpose of the foundation is to find" a cure for HIV broadly applicable up to 2020 "to finally clarify that it really aims to help lay the scientific foundations of a" cure. " AmfAR released a press release announcing the February 2014 cure. An initiative that has never been clarified.

[A note from the editor: Who watched "Waiting for a Miracle," with Tom Hanks, the controversial work of Stephen King, one should remember the final sentence: "The last mile is the longest." (...)]

However, Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH), says that success in front of healing is a matter of "if" in instead of "when."

"That does not mean there's no hint of giving up on trying," he says. "But you need to understand where you're in the process."

Contrary to the overly effusive trend reports on the healing progress, CNN showed a headline on its website July citing the French virologist Françoise Barré-Sinoussi, PhD, co-discoverer of HIV, which claimed that "developing healing is almost impossible"

Headers are by their reductive nature, certainly due to space constraints, but perhaps even more so because journalists' efforts at attracting readers often subvert nuance or specificity in the text. In this case, CNN left many with the unfortunate impression as inaccurate as the notion that a cure is just around the corner that we all hope that the Barré-Sinoussi thought was lost. But as the interview explains, winner of the Nobel Prize claim was more pragmatic than pessimistic and articulated in his description of the extreme difficulty of eliminating all the latest infected cells in the body of HIV. (When referring to the success of such a feat, many scientists use a more specific terminology, a healing sterilization. He argued that what she called remission, in which the virus is brought to very low levels and daily kept there without medication, is a more feasible goal that others call functional cure.

Miracle letterpress

Of course there is a person who aparentemenet was cured of HIV:

Timothy Ray Brown.

The 49-year-old American also known as the Berlin patient, a city where he was treated for leukemia and to whom two bone marrow transplants were given in 2007 and 2008 from a donor whose immune cells were naturally resistant to HIV due to a genetic mutation inherited around 1% of Caucasians (a mutation) have. Leukemia is from bone marrow cancer, which makes immune cells. A bone marrow transplant offers an individual something of someone who will help recreate the immune system after the diseased immune system has been intentionally destroyed, usually by chemotherapy.)

Until Brown's case was first reported, and then widely announced, at 2008, a cure for HIV was the ambition to investigate those who did not dare to pronounce his name. The absence of virus replication in the body of the established chestnut that scientists call proof of principle - in this case, that cure is possible and shake the field of healing for life. More scientists have not received scholarships and scholarships for these studies and they have not flowed.

Note from the editor soropositivo.Org

I read a scientific text that could not copy that describes the process that cured the Berlin Patient, become a thing serially something at least reckless.

Of the three people who went through the same process that Brown two lost their lives on the operating table and the other did not get the same results, and if I were a doctor, I would say that the Berlin patient's cure is more like a cyst of 6 cm in my right kidney was discovered in ultrasound examination of my abdomen, "a laboratory finding" (I Fawn this kidney cyst and it's bigger than my Dirito kidney and yet is harmless) ..

The challenge before them is formidable. The main enemy viral reservoir is an amorphous body composed of cells infected with the virus replication in a suspended state, and canBrain impulses. Thinking prosess.
also include infected cells beyond the reach of standard treatment, such as in the brain. The standard for HIV treatment does not eliminate the reservoir because ARVs only work when a cell is replicating and because not all drugs can cross the blood-brain barrier call.

Unfortunately, Brown curing cure is not widely applicable. Such cancer treatments, which are highly expensive, have a steep mortality rate; post-Brown, similar efforts to cure HIV and cancer simultaneously in six other failed or individuals died before investigators can determine if the cure of HIV has been successful. Attempts to prepare the body for a bone marrow transplant with a less potentially lethal strategy also means not defeat HIV.

CNC machining station at work. Milling, threading industry.A critical obstacle facing efforts for healing is that scientists have not yet developed refined tools enough to determine with absolute certainty that no infected cells in hidden latency in one's body that may in later years to life, start producing new copies of the HIV and eventually repopulate the reservoir. An important element of the research and work of discovery that characterizes the healing field in large measure today is the attempt to map the reservoir and to develop tests that can accurately measure its presence. Versions of such springs tests are helping scientists to determine the success of current attempts to at least reduce the size of the reservoir.

The disappointing case of the notorious Mississippi Baby illustrates not only the pitfalls of this inability to correctly detect and measure the reservoir but also the lack of standards for describing a cure or anything of HIV in that which is generically approximated to the scientific community.

The Conference on Retroviruses and 2013 Opportunistic Infections (CROI) in Atlanta, Deborah Persaud, MD, a pediatric infectious disease researcher at the Johns Hopkins Children's Center, she announced that a baby with at the time 18 months of Mississippi had been healed Functionally HIV.

In some ways, the "functional" qualifier recognizes the impossibility of declaring success in achieving a cure sterilization. Again, a functional cure is usually set when there is no official definition as a case in which a person is not contagious and although he or she still harbor HIV and the virus is under control without the need for ART.

Pile of various colorful pills background.

After the baby was infected in Mississippi during birth, at birth, the vertical channels of the mother who refused to use antiretroviral drugs for her daughter, in the blood of crucible in which a delivery room turns, doctors quickly began their therapy in a cocktail of aggressive and atypical antiretrovirals. His mother finally discontinued treatment, and the first time Persaud presented the case to fellow scientists, the girl had spent ten months off ART without viral rebound in the absence of ART. highly sensitive tests could, however, continue to detect the virus remains in your body. Persaud says she used the word "working" at the time because he felt he had not spent enough time to confirm that the child was simply cured.

This period came to an end after 27 months when the viral load of the child jumped and she was replaced on ART in 2014.

"This really provides a great field to think about, evaluate, test, and then try to stop and think about terminology and expectations," reflects Persaud, who is among the leaders of a study looking to replicate the baby's case. Missions in newborns infected at birth around the world.

Editor's note. Here at this site you can search by clicking on this link transmission and you will see, for example, that there are already four or five years that no one unborn seropositive in the city of coast Santos of São Paulo and, a little further, you can see that Cuba was considered by the World Health Organization as that "finalized" within the vertical transmission (from mother to child at birth).

There is hope that other children may be better off than the Mississippian Baby (whose case, along with other healing attempts failed, taught scientists a great idea and helped shape and advance the future of research). The July Meeting of the International AIDS Society conference in Vancouver, British Columbia, reports that a French 18 year-old woman and a woman who has twelve years of experience about her life after being born with HIV, receiving prophylactic treatment and then lived for six years combination therapy before leaving treatment. Some researchers may still find HIV DNA in their body, but it has no detectable viral replication in their plasma.

View on Eiffel tower at sunset
Another dozen French, known as the Visconti cohort individuals remained in a state of remission throughout a decade after stopping Antiretroviral Therapy, all started within six months from the transmission of HIV. Scientists believe that in each of them, as early treatment prevented the viral reservoir significantly incutisse

Asier Sáez-Cirión, PhD, of the Pasteur Institute in Paris, presented for the first time data on Visconti in cohort of 2011; but, in his words, the news rose "almost unnoticed" at the moment. In recent years he has gained more interest, but nothing compared to the baby of the Mississippi. The great disparity in the attention directed to Sáez-Cirión and respective announcements of Persuad can be attributable to the semantics. Sáez-Cirión from the beginning of his work has moved away from the glamor and emotion of the word "cure", with or without a qualifier and decidedly insisted on characterizing these French individuals as just and only a state of remission.

The word "remission", Sáez-Cirión, evokes a concept people are familiar with cancer: The disease is over but there is always a chance that it could return. "When you use the term" functional "he adds," sometimes the "functional" part is interrupted and the part that says 'cure' continues. And it creates a certain confusion. "

In fact, many of the headlines on the Mississippi baby established that it was healed, so without any semantic care, leaving the raw message, no polish or other care in writing, opening the wings of imagination of all who read the to give it any nuance. Touting their contributions to the case (another possible reason for the case received as received as much attention in the media), amfAR said in a press release that "confirmation of cure was possible," in part by a grant from Persaud amfAR to support the study (SIC).

In sharp contrast to the survey of Steps Foundation, director of research at amfAR, Rowena Johnston, PhD, a measured tone when describing the current state of research on the cure of HIV infection, saying "thoughts around major challenges are beginning to accrete (opens in another browser tab). Not that researchers have necessarily found answers or all answers. But what people are actually beginning to agree that the challenges are likely to be dismantled"

An important factor which is increasingly coalescence and money. According to a report July's global HIV advocacy group AVAC, a global public and philanthropic healing research investment jumped by 82% between 2012 and 2014 from US $ 88 million to $ 160 million. The lion's share comes from the United States, mainly in the form of grants, with $ NIH 114 2014 million and an estimated level of $ 127 million scheduled for 2015. The amfAR you want to quickly scale their funding from annual amount 4,4 million in 2014 to offer researchers a total of 100 million dollars over a period of six years from 2015. The Gates Foundation awarded about $ 9 million for cure research in 2014.

Such figures are still meager compared to the latest investments in HIV vaccine research; NIH spends more than half a billion dollars annually on this front. According to S. Fauci, the disparity between the funding of the cure and the vaccine is not a reflection of the agency's lack of enthusiasm for the cause of the cure. Instead, vaccines get more money because the field is more advanced; vaccines are mainly in the field of development, rather than discovery, or stage.

HVAC global cure research figures do not account for expenses industry. GSK recently pledged to 20 million dollars over five years for a joint effort with the University of North Carolina (UNC) at Chapel Hill. In addition, Merck, Gilead Sciences, Janssen, and biotech companies Calimmune Sangamo BioSciences and are all in the search.

The field is increasingly collaborative. At 2011, the NIH established the Martin Delaney Collaboratories, which encouraged cooperation between academia and the private sector. There is also collaboration between fellows of amfAR.

When it comes to research that goes beyond background study and progresses in curative therapies, the actual greatest focus is on a method known as "kick and kill." In the first part of this phase-kicking strategy in an agent, or combination of agents, it propels the latent "machinery" of infected cells back into action. The subsequent killing challenge is in part to find ways to cleanse the body of newly activated cells.

Unfortunately, ARVs do not kill HIV-infected cells. Neither the immune system, in part because these cells have so few specific HIV antigens on their surfaces (Antigens the flag of a cell that allows the same infected and feels like to summon help an immune response). The problem of confusion, the immune response of people with HIV may have decreased after years taking ART and the virus latently infected cells may be able mutant strains resist to the main line of immune response.

Robert Confitada's MD, PhD laboratory at Johns Hopkins University leads the field "Kicking and Killing," which includes efforts from more than two dozen groups around the world, such as the UNC-GSK team and the Danish laboratory which has won the wrong headlines. Researchers are testing at least six walking gait agents in humans, including HDAC, inhibitorsvorinostat, panobinostat and romidepsin.

Scientists are exploring on several ways to increase the immune response of the front KICK in order to give rise to immune cells or antibodies that can more effectively attack the newly awakened infected cells.

According to David Margolis, MD, who led the effort to UNC kicking and killing is still "in its infancy," but it has enjoyed some recent advances. "The greatest limitation to progress now," says Margolis, "is that we have not yet truly developed diagnostic tools that they are safe and effective and that they demonstrate that the reservoirs so that the reservoirs are sufficiently impoverished and that we can measure. " In other words, research with kicking, part of the strategy, is only at the beginning, any results are particularly insufficient. "I think we will then wait for something that is not too long, maybe a year or two, and we will have the forward movement where some form of progress is being made."

However, S. Fauci "is not sure that the global shock and approach of kicking and killing" will succeed.

Even more to the realm of science fiction is achievable research in curative gene therapy. Researchers are trying to recreate the event Tim Brown (at least partially), but without the danger and the impracticality of a traditional bone marrow transplant (editor's note Click here ara get a good definition of marrow transplant. The text will open in another tab or window of your browser, but in Portuguese)

The donor marrow Brown had a genetic mutation that prevented the development of infection which would be the donor itself, called coreceptor CCR5 which is located on the surface of immune cells CD4 that are the targets of HIV. Without CCR5, Most copies of HIV does not catch on immune cell count, let alone infects. So scientists Sangamo and the Fred Hutchinson Cancer Research Center, among others, are experiencing the drawing with HIV positive immune cells of the individual or of immune cells that produce stem cells

(Stem cells, mother cells or stem cells are cells that have the best ability to divide giving rise to two cells similar to the originals.From Wikipedia, the free encyclopedia redirecionado of Stem cells) and editing your code to prevent the development of coreceptor CCR5. (Editor's note: if this is or was obtdo, HIV would be in blood plasma, almost adrift, hunted - I like to think of it - by antibodies to the last copy of its RNA Source of the scientific part Wikipedia (opens on another tab) Source of the cruel part: Myself 🙂

Sangamo has had some promising results from gene therapy company, with a man with 32 years out of therapeutic regimens (HAART) for more than a year and a half after an infusion edited cells (stem cells), resistant to HIV. He is not cured of HIV infection, which is still actively replicating but his viral load is only about 500 and his CD4 level has remained stable (The article does not mention the CD4 rate).

This is a partial example of success that researchers can build on as they reach a partial success; but, especiallyA success. Each of these individual steps can offer new and exciting benefits for the health of people living with HIV. Ultimately, several approaches may be needed to hit the virus more efficiently than the ART is already able to do.

"There are many routes of attack" in the quest for cure of HIV infection, say Nobel laureates, virologist David Baltimore, Ph.D., Professor of the California Institute of Technology and founder of Calimmune, "and from my point of view , the word healing is, perhaps, misleading. What we want to do is to make this disease, HIV infection, into a lesser and less debilitating disease. And what that means is to limit the effects of the virus and also move towards forms of therapy that are less debilitating for the patient ".
closeup round white pill in hand

Another incremental advancement that research can achieve cure is to reduce the low level reproduction of viral replication that occurs even in the presence of successful ART treatment. Scientists suspect this virus activity may stimulate the immune system in a state of chronic inflammation, and believes it is to contribute to the increased risk of age-related disorders among people living with the virus. Another short-term ambition is for treatments that would allow extended periods of remission, giving HIV-positive people anti-viral in a safe way of living a time off toxicities da ART.

Shrinking vastly, but not completely eliminating the reservoir, may allow such extended remission. If at the point, members of the Visconti cohort do not have zero reservoir; are only very small reservoirs in each of them. (Scientists have the tools to determine this.) A recent study found that if someone stops taking HAART will on average pass a week before at least one infected latent cell becomes reactive successfully that is able to initiate a rebound viral. Considering the large number of cells in the typical reservoir, the implication is that any cell only rarely jumps into meaningful action. Based on these observations, the authors estimated that an 50-A-70-fold reduction in reservoir size can extend the time between the stop and a viral rebound in need of antiretroviral therapy for an average of once year. Confit made his projection that some people with HIV could experience learning remission with something around 1.000-10,000 * reduction fold reservoir.

"We could get interventions where I work a good deal of time in positive sections of the people," says AmfAR Johnston. "And so it's going to be this interactive process over time to come up with an intervention that will heal most people most of the time. Maybe as good as we can wait. "

Editor's note: In the case of the 1.000 10.000 as is no transmission of the virus, and as an undetectable viral load <4o? It would be a return to the transfer?

Translated from original The Cure For HIV Is Not Around the Corner de Benjamin Ryan by Claudio Souza in 16 February 2016

Yes, this is the photo of me! My niece asked me to put this picture on my profile! .... I had here a description of me that one person described as "irreverent". This is really a euphemistic way of classifying what was here. All I know is that an "NGO" which occupies a building of 10 floors has established a partnership with me, and I have the logs of the partnership time, which was more a vampirism because for each 150 people leaving my site, clicking on them, there was, on average, one that came in. WHEN I ENTERED AND ENTERED

6 Comments

  1. [...] The Sunday Times reported that British scientists are on the brink of a cure for HIV infection. In fact, the study is still in its early stages and will not be able to describe the participants as "cured" until an extensive follow-up takes place and is carried out. Professor Sarah Fidler, a researcher at Imperial College, London, told the Sunday Times that study participants will be followed for five years. (For example, this study already surpasses the propitious forecast, in that clip, an overproduction of ...).

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