There is life with HIV

Cure for HIV is not there in front around the corner ... But there is hope!

Cut through the hype and hyperbole.

There is much to be done in the field of scientific advances until they find a cure for AIDS

I, Cláudio Santos de Souza, since this video, knowing that the person responsible for his placement can prevent it from being displayed here.

Before proceeding I ask what is the suit of "activist" who hides behind an avatar?

I know and respect (some I love) many activists. And not all I know personally. But I saw their faces, dozens of times, on facebook, twitter, Instagram, on their personal websites and more importantly, I know their names!

You need to think you can trust someone who "fight for you", but hiding in the anonymity of a "nickname" and an avatar. Because that's all we know, the summary of summaries ...

If you do not see the video here you will find the link to it at the end of this introduction.

I recommend you to watch this video carefully and a certain amount of skepticism. This video gave rise to the text that I translated below, which should be read carefully.

I consider at least a reckless action spread this video, which makes people think about things they can change their sexual behavior when it comes to safety in relations, leading to a considerable increase, and even tragic AIDS cases throughout the planet as a result fatal to humans, victims of people without regard for human life!

The video has given rise to this text and I suggest that you read carefully with eyes and reasoning. They are trying to make us believe something that might not be realized. I work for almost seventeen years with this site and I take very, very careful what you publish, because I know I deal directly with public health involving human lives.

If the video is not here look for in YOUTUBE(The link opens in another tab to the right of where you are now). I do not disregard the idea of ​​it being reallocated to another URL, and perhaps you can find it looking for this expression:

as I predicted, the incorporamento was blocked. For those interested in joining ...

But ... The video is there! And below it, the response of the scientific community

If you do not find, warn meAs well I know I got it to be removed. :) And I recolocarei back to warn about this kind of irresponsibility, like a lighthouse on the rocks, with such a strong light that no fog can overshadow.

Claudio Souza. Seropositive since 1994.
Claudio Souza. Seropositive since 1994.

Liver - Female Organs - Human AnatomyThe news in April 2013. The Danish researchers said was a matter of "mere months"(Opens in another tab and I was also one of those who fell in the hopeful news) to find a cure for HIV. Other media eagerly took the electrifying report, and the words crossed the planet in online newspapers and, after that, of course, reached social media, which promoted the idea that it was a matter of waiting (para it has been a matter of waiting there twenty-two years) To speak of "for an end to the HIV / AIDS epidemic, and that this could happen soon become reality."

There was a difficulty: the UK surprisingly placed on the first page of a newspaper, "Scientists on the Verge of cure of HIV infection."

It was not true. Researchers from Aarhus University Hospital in Aarhus, Denmark, were and are still searching for a cure for HIV. A Danish scientist who is investigating an anti-cancer known as histônica deacetylase (HDAC inhibitors) as a means to wash the virus called "latent reservoir where it (HIV) is hidden, escaping from antiretroviral treatment (ART). But at Aarhus University research is just one of the early stages of the processes several years before testing in humans. And there is no guarantee that researchers are no more than scratch the surface of the arduous task of finding a cure for the widely complex process of viral infection such as HIV infection.

The Telegraph, which eventually revised the article online, while the hospital launched its own correction, were practically alone in the request, or at least implying that a cure of the infection for HIV infection would be imminent. Not only is the health of HIV concern that inspired this wrong hyperbole. Since President Richard Nixon announced the "war on cancer" in 1971, with news they have repeatedly raised the hopes of the great victory ahead.

Usually an enticing headline related to HIV comes from medical sites daily, as those in March 2015, get excited to say that a functional cure for the virus is not completely eliminated from the body but is under control without ARVs was a approach to reality step.

However, Michael Farzan, PhD, a prominent researcher of curing HIV infection, a professor at Scripps Research Institute in Florida, says, "It's hard to say how far we are from start to finish" in the search for a cure for HIV. "Who knows; we could have moved in an inch in a march of 100 miles. "

Zhi Hong, Ph.D., chief research in infectious diseases GSK (GlaxoSmithKline), which is one of several pharmaceutical companies to invest in curing research, puts the issue in a more definitive way: "There is no illusion that [healing] can still cost a monumental investment of money and decades to come to materialize."

Zealous members of the media are practically the only ones to contribute to inaccurate perceptions of cure of public research. Perhaps unwittingly, his words have gone unlike all other public posts its foundation focused on global health co founder of Microsoft, Bill Gates told participants at the World Economic Forum in January that both an HIV vaccine as the means to avoid people living with HIV have the need to take daily ARV arrive until 2030.

Richard Nova Lima, an expert by the search for a vaccine and cure against HIV in Action Treatment Group, said in a post on the TAG website, expressed the following reasoning:

"Hope does not equal the inevitability."

Regarding the enthusiasm of Gates, New Lima wrote, "have no scientific basis; there were encouraging signs of progress on the vaccine and cure on some fronts in recent years - but the challenges that lie ahead should not be underestimated

Then there is a lush and hyperbolic amount of messages from amfAR Foundation to raise funds for the fight against AIDS, for research on AIDS, which sends frequent emails signed by CEO Kevin Frost in which he characterizes non-profit organization for the countdown of the "cure", a self initiative as outlined devoted to "end unlocking the mysteries of HIV" or clearing the "final obstacles" that are still blocking a cure for HIV infection.

A video very high concept, in terms of merchandising, amfAR in April states that the fight against HIV has the "final mile an epic journey" and that "the cure for all is close. The End of the Day is finally in sight. All we need to do is grab the torch and touch the finish line. "Only at the end of 1.000 words promotional text amfAR sets as the respective done pivot repeatedly stressed that the purpose of the foundation is to find" a cure for HIV broadly applicable to 2020 "to finally clarify that really aims to help establish the scientific foundations for a" cure. " AmfAR has released a press release announcing the cure in February 2014. Initiative that was never clarified.

[A note from the editor: Who watched "Waiting for a Miracle," with Tom Hanks, the controversial work of Stephen King, one should remember the final sentence: "The last mile is the longest." (...)]

However, Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH), says that success in front of healing is a matter of "if" in instead of "when."

"This does not mean that there is no evidence of withdrawal to try," he says. "But you need to understand where you are in the process."

Contrary to the overly effusive trend reports on the healing progress, CNN showed a headline on its website July citing the French virologist Françoise Barré-Sinoussi, PhD, co-discoverer of HIV, which claimed that "developing healing is almost impossible"

The headers are by their reducing nature, certainly due to space constraints, but perhaps even more so because the efforts of journalists in attracting readers often subvert nuance or specificity in the text. In this case, CNN left many with the unfortunate impression as inaccurate as the notion that a cure is just around the corner that we all hope that the Barré-Sinoussi thought was lost. But as the interview explains, winner of the Nobel Prize claim was more pragmatic than pessimistic and articulated in his description of the extreme difficulty of eliminating all the latest infected cells in the body of HIV. (When referring to the success of such a feat, many scientists use a more specific terminology, a healing sterilization. He argued that what she called remission, in which the virus is brought to very low levels and daily kept there without medication, is a more feasible goal that others call functional cure.

Miracle letterpress

Of course there is a person who aparentemenet was cured of HIV:

Timothy Ray Brown.

The American 49 years of age also known as the Berlin patient city in which he was treated for leukemia and who were given two bone marrow transplants in 2007 and 2008 from a donor whose immune cells are naturally resistant HIV thanks to an inherited genetic mutation about 1% of Caucasians(A mutation) have. Leukemia is cancer of bone marrow, which produces immune cells. A bone marrow transplantation offers an individual something that someone will help the immune system to recreate, after the patient's immune system have been intentionally destroyed, usually by chemotherapy).

Even Brown's case be reported for the first time, and then widely announced in 2008, a cure for HIV was the investigation of ambition of those who did not dare to pronounce his name. The absence of virus replication in established Chestnut body that scientists call proof of principle - in this case, that healing is possible and to shake the healing field for life. Most scientists did not receive scholarships and financial grants for these studies and they do not have flowed.

Note from the editor soropositivo.Org

I read a scientific text that could not copy that describes the process that cured the Berlin Patient, become a thing serially something at least reckless.

Of the three people who went through the same process that Brown two lost their lives on the operating table and the other did not get the same results, and if I were a doctor, I would say that the Berlin patient's cure is more like a cyst of 6 cm in my right kidney was discovered in ultrasound examination of my abdomen, "a laboratory finding" (I Fawn this kidney cyst and it's bigger than my Dirito kidney and yet is harmless) ..

The challenge before them is formidable. The main enemy viral reservoir is an amorphous body composed of cells infected with the virus replication in a suspended state, and canBrain impulses. Thinking prosess.
also include infected cells outside the range of standard therapy such as in brain. The standard for HIV treatment does not eliminate the reservoir because ARVs only work when a cell is replicating and because not all drugs can cross the blood-brain barrier call.

Unfortunately, Brown curing cure is not widely applicable. Such cancer treatments, which are highly expensive, have a steep mortality rate; post-Brown, similar efforts to cure HIV and cancer simultaneously in six other failed or individuals died before investigators can determine if the cure of HIV has been successful. Attempts to prepare the body for a bone marrow transplant with a less potentially lethal strategy also means not defeat HIV.

CNC machining station at work. Milling, threading industry.A critical obstacle facing efforts for healing is that scientists have not yet developed refined tools enough to determine with absolute certainty that no infected cells in hidden latency in one's body that may in later years to life, start producing new copies of the HIV and eventually repopulate the reservoir. An important element of the research and work of discovery that characterizes the healing field in large measure today is the attempt to map the reservoir and to develop tests that can accurately measure its presence. Versions of such springs tests are helping scientists to determine the success of current attempts to at least reduce the size of the reservoir.

The disappointing case of the notorious Mississippi Baby illustrates not only the pitfalls of this inability to correctly detect and measure the reservoir but also the lack of standards for describing a cure or anything of HIV in that which is generically approximated to the scientific community.

The Conference on Retroviruses and 2013 opportunistic infections (CROI) in Atlanta, Deborah Persaud, MD, a research of pediatric infectious diseases at the center infantilJohns Hopkins, she announced that a baby with at the time 18 months old Mississippi had been healed Functionally HIV.

In some ways, the "functional" qualifier recognizes the impossibility of declaring success in achieving a cure sterilization. Again, a functional cure is usually set when there is no official definition as a case in which a person is not contagious and although he or she still harbor HIV and the virus is under control without the need for ART.

Pile of various colorful pills background.

After the baby was infected in Mississippi during birth, at birth, the vertical channels of the mother who refused to use antiretroviral drugs for her daughter, in the blood of crucible in which a delivery room turns, doctors quickly began their therapy in a cocktail of aggressive and atypical antiretrovirals. His mother finally discontinued treatment, and the first time Persaud presented the case to fellow scientists, the girl had spent ten months off ART without viral rebound in the absence of ART. highly sensitive tests could, however, continue to detect the virus remains in your body. Persaud says she used the word "working" at the time because he felt he had not spent enough time to confirm that the child was simply cured.

This period came to an end after 27 months when the viral load of the child jumped and she was replaced on ART in 2014.

"This event offers, really, is a great field to think, evaluate, test and experience then stop and think about terminology and expectations," reflects Persaud, who is among the leaders of a study that seeks to replicate the case of a baby's Mississippi birth to infected babies worldwide.

Editor's note. Right here on this site you can search by clicking this linktransmission and you will see, for example, that there are already four or five years that no one unborn seropositive in the city of coast Santos of São Paulo and, a little further, you can see that Cuba was considered by the World Health Organization as that "finalized" within the vertical transmission (from mother to child at birth).

There is hope that other children the result may be better than the Baby Mississippi (which case, along with other healing attempts failed, taught scientists a great idea and helped shape and drive the future of research). The Meeting conference July International AIDS Society in Vancouver, British Columbia, news that a French 18 years old and a woman who has twelve years of experience in his life after being born with HIV, receiving prophylactic treatment and then lived six years on HAART combination therapy before leaving the treatment. Some researchers may also find DNA of HIV in his body, but she has no detectable viral replication in their plasma.

View on Eiffel tower at sunset
Another dozen French, known as the Visconti cohort individuals remained in a state of remission throughout a decade after stopping Antiretroviral Therapy, all started within six months from the transmission of HIV. Scientists believe that in each of them, as early treatment prevented the viral reservoir significantly incutisse

Asier Sáez-Cirion, PhD, of the Pasteur Institute in Paris, first presented data on the Visconti in 2011 cohort; but just in his words, the news went "almost unnoticed" at the time. In recent years he got more interested, but nothing compared to Mississippi baby. The great disparity in attention directed to Saez-Cirion and their Persuad ads may be attributable to semantics. Saez-Cirion since the beginning of his works turned away from the glamor and excitement of the word "cure", with or without a qualifier and resolutely insisted characterize these individuals as French only and solely a state of remission.

The word "remission," Saez-Cirion, evokes a concept people are familiar with cancer: the disease was over, but there is always a chance that he could return. "When you use the term cure" functional, "he adds," sometimes "functional" part is interrupted and the part that says 'cure' remains. And it creates some confusion. "

In fact, many of the headlines on the Mississippi baby established that it was healed, so without any semantic care, leaving the raw message, no polish or other care in writing, opening the wings of imagination of all who read the to give it any nuance. Touting their contributions to the case (another possible reason for the case received as received as much attention in the media), amfAR said in a press release that "confirmation of cure was possible," in part by a grant from Persaud amfAR to support the study (SIC).

In sharp contrast to the survey of Steps Foundation, director of research at amfAR, Rowena Johnston, PhD, a measured tone when describing the current state of research on the cure of HIV infection, saying "thoughts around major challenges are beginning to accrete(Opens in another browser tab). Not that researchers have found answers or necessarily all the answers. But what people are really starting to agree that the challenges are capable of being removed"

An important factor which is increasingly coalescence and money. According to a report July's global HIV advocacy group AVAC, a global public and philanthropic healing research investment jumped by 82% between 2012 and 2014 from US $ 88 million to $ 160 million. The lion's share comes from the United States, mainly in the form of grants, with $ NIH 114 2014 million and an estimated level of $ 127 million scheduled for 2015. The amfAR you want to quickly scale their funding from annual amount 4,4 million in 2014 to offer researchers a total of 100 million dollars over a period of six years from 2015. The Gates Foundation awarded about $ 9 million for cure research in 2014.

Such values ​​are still scarce compared to the last vaccine research investment against HIV; NIH spends more than half a billion dollars annually on this front. According to Fauci, the disparity between the funding of cure and the vaccine is not a reflection of the lack of agency's enthusiasm for the cause of healing. Instead, vaccines get more money because the field is more advanced; Vaccines are mainly in the field of development, rather than discovery, or phase.

HVAC global cure research figures do not account for expenses industry. GSK recently pledged to 20 million dollars over five years for a joint effort with the University of North Carolina (UNC) at Chapel Hill. In addition, Merck, Gilead Sciences, Janssen, and biotech companies Calimmune Sangamo BioSciences and are all in the search.

The field is increasingly collaborative. In 2011, the NIH established the Martin Delaney collaboratories, which encouraged cooperation between the academic world and the private sector. There is also collaboration between grantees of amfAR.

When it comes to research that goes beyond the background study and progress in healing therapies, the real main focus is on a method known as "shoot and kill". In the first part of this phase of kick strategy an agent or combination of agents, impels the "machinery" of latent infected cells back into action. The challenge to kill subsequent is partly to find ways to cleanse the body of the newly activated cells.

Unfortunately, ARVs do not kill HIV-infected cells. Neither the immune system, in part because these cells have so few specific HIV antigens on their surfaces (Antigens the flag of a cell that allows the same infected and feels like to summon help an immune response). The problem of confusion, the immune response of people with HIV may have decreased after years taking ART and the virus latently infected cells may be able mutant strains resist to the main line of immune response.

The laboratory of Robert confit, MD, PhD at Johns Hopkins University, leads the field "kick and kill," which includes efforts of more than two dozen groups around the world, such as the UNC-team GSK and the Danish laboratory who won the wrong headlines. Researchers are testing at least six latency march agents in humans, including HDAC, inhibitorsvorinostat, panobinostat and Romidepsin.

The scientists are exploring on various ways of increasing the immune response of KICK forward in order to give rise to antibodies or immune cells that can more effectively attack the newly awake infected cells.

According to David Margolis, MD, who led the effort to UNC shoot and kill is still "in its infancy", but he has enjoyed some recent advances. "The biggest limitation to progress now," says Margolis, "is that we have not yet really developed the diagnostic tools that are safe and effective and to demonstrate that the reservoir so that the reservoir are sufficiently depleted and we can measure. " In other words, research on the kick, part of the strategy is only the beginning, any results are particularly inadequate. "I think after something other than wait too long, maybe a year or two and we will move forward on that account some form of progress."

However, S. Fauci "is not sure that the global shock and approach of kicking and killing" will succeed.

Even more to the realm of science fiction is achievable research in curative gene therapy. Researchers are trying to recreate the event Tim Brown (at least partially), but without the danger and the impracticality of a traditional bone marrow transplant (editor's note Click here ara get a good definition of marrow transplant. The text will open in another tab or window of your browser, but in Portuguese)

The donor marrow Brown had a genetic mutation that prevented the development of infection which would be the donor itself, called coreceptor CCR5 which is located on the surface of immune cells CD4 that are the targets of HIV. Without CCR5, Most copies of HIV does not catch on immune cell count, let alone infects. So scientists Sangamo and the Fred Hutchinson Cancer Research Center, among others, are experiencing the drawing with HIV positive immune cells of the individual or of immune cells that produce stem cells

(Stem cells, mother cells or stem cells are cells that have the best ability to divide giving rise to two cells similar to the originals.From Wikipedia, the free encyclopedia redirecionado of Stem cells) and editing your code preventing the development of coreceptor CCR5. (Editor's note: if this is or was obtdo, HIV would be in blood plasma, almost adrift, hunted - I like to think of it - by antibodies to the last copy of its RNA Source of the scientific part Wikipedia (Open in another tab) Source of cruel part: Myself

Sangamo has had some promising results from gene therapy company, with a man with 32 years out of therapeutic regimens (HAART) for more than a year and a half after an infusion edited cells (Stem cells) resistant to HIV. He is not cured of HIV infection, which is still replicating actively but your viral load is only about 500 and their level of CD4 remained stable (The article does not mention the CD4 rate).

This is a partial example of success that researchers can build on as they reach a partial success; but, especiallyA success. Each of these individual steps can offer new and exciting benefits for the health of people living with HIV. Ultimately, several approaches may be needed to hit the virus more efficiently than the ART is already able to do.

"There are many attack routes" in the search for a cure for HIV infection, say winners of the Nobel Prize, the virologist David Baltimore, PhD, Professor at the California Institute of Technology and founder of Calimmune, "and from my point of view the word cure is perhaps misleading. What we do is make this disease, HIV infection, a smaller and less debilitating. And what that means is to limit the effects of the virus and also move towards forms of therapy that are less debilitating for the patient ".
closeup round white pill in hand

Another incremental advance that research can achieve a cure is to reduce the reproduction of low-level viral replication that occurs even in the presence of successful treatment with ART. Scientists suspect this virus activity can stimulate the immune system in a state of chronic inflammation, and believes it is contributing to the increased risk of age-related disorders among people living with the virus. Another short-term ambition is for the treatments that allow long periods of remission, giving antivirals to HIV-positive people a safe way to live a whileoff toxicities da ART.

Vastly shrinking but not totally eliminating the reservoir may allow such extended remission. Case in point, the members of the Visconti cohort have zero reservoir; They are just too small reservoirs each. (Scientists have the tools to determine this.) A recent study found that if you stop taking ART will spend, on average, a week before at least one infected dormant cells become reactive successfully to be able to start a rebound viral. Considering the large number of typical reservoir cells, the implication is that any cell only rarely jumps into meaningful action. Based on these observations, the authors estimated that an 50-A-70-fold reduction in reservoir size can extend the time between the stop and a viral rebound in need of antiretroviral therapy for an average of once year. Confit made his projection that some people with HIV could experience learning remission with something around 1.000-10,000 * reduction fold reservoir.

"We could get interventions that work a good deal of time in positive sections of the people," said amfAR Johnston. "And so it will be this iterative process over time until reaching an intervention that will cure most people most of the time. Maybe as good as we can expect. "

Editor's note: In the case of the 1.000 10.000 as is no transmission of the virus, and as an undetectable viral load <4o? It would be a return to the transfer?

Translated from originalThe Cure For HIV Is Not Around the Corner ofBenjamin Ryan by Claudio Souza in 16 February 2016

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5 thoughts on "Cure for HIV is not there in front around the corner ... But there is hope!"

  1. Pingback: The Suffering Drama of the Eternal Immune Window and My Answer to Ryan - Seropositive.Org - There is life with HIV

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