A Look Editor. I am about to finish an important article dealing with this thing called "blip" viral. After searching in several dictionaries I started to look at my sources which could be a "viral blip". And with rare happiness, I found this article, whose sources are techne cited at end of article
Some people experience transient viral load increases that are called "viral blipes. Viral load quickly returns to an undetectable level without any change in therapy. Several studies have found that the 20 60% of patients with viral suppression with some experience viral blipes (depending on the regimen used and the frequency of viral load testing), and perhaps a third of repeated experiments. Most blipes are small, with viral load up to somewhere between 50 and 1000 copies / ml.
Blipes can have various causes, including variation in the testing process, temporary changes in drug concentration or transient discharges of immune activation, for example due to having received a vaccine or an infection such as influenza. A study measuring the viral load in blood samples of ten patients every three days for four months two separate laboratories. Nine patients presented with one or more blipes viral load, but only one of 18 total blipes was detected by two laboratories at the same time.1
While a reduction in adhesion can cause an increase in viral load, most studies have shown that people who live blipes experience have no worse adhesion than those with undetectable viral load consistently nor adhesion is necessarily less before a blip .2In addition, drug levels before, during and after the blip viral load are often higher than the minimum recommended concentrations of drugs.3,1
Most doctors believe that an isolated viral load, a blip, it's nothing to worry about. However, several blipes, or those who began to occur with increasing frequency, may be an early sign of imminent expiry treatment failure.
Blipes also are not necessarily associated with drug resistance emergence.4However, some studies suggest that transient increases in viral load may be a sporadic signal activation of the immune system and may help to replenish latent viral reservoirs.5
The relationship between blipes and viral load and immune recovery is clear.3 6Even with the best available therapy and optimal adherence, viral blipes may occur. For this reason, orientaça be advised that viral load should be checked at least twice to see if the increase is a continuing trend before deciding to change treatment.
- RE Nettles et al. Intermittent HIV-1 viremia (blips) and drug resistance in Patients receiving HAART. JAMA 293: 817-829, 2005
- LG Miller et al. Episodes of transient HIV viraemia (blips) are not associated with drops in medication adherence. Antivir Ther 8: S396, 2003
- V Martinez et al. HIV-1 intermittent viraemia in Patients treated by non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS 19: 1065-1069, 2005
- PK Lee et al. HIV-viral load blips 1 are of limited clinical significance. J Antimicrob Chemother 57: 803-805, 2006
- LE Jones and Perelson AS Transient viremia, plasma viral load, and replenishment reservoir in HIV-infected Patients on antiretroviral therapy. J Acquir Immune Defic Syndr 45: 483-493, 2007
- PW Hunt et al. Continued CD4 cell count Increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy. AIDS 17: 1907-1915, 2003