Men from middle age living with HIV age faster, proves DNA methylation study

Acceleration of epigenetic clock

last-minute-alarm-clock-icon-vector-illustrationThese studies establish a scenario using methylation patterns to investigate whether people with HIV advance their organ age faster than uninfected, said Ideker, who for the new study collaborated with Howard S. Fox, MD, PhD, professor and vice - executive chair of pharmacology and experimental neuroscience at the University of Nebraska Medical Center in Omaha.

His research team took blood samples from a total of 137 non-Hispanic white men aged 25 to 68 years who were infected with HIV and taking antiretroviral therapy. In addition, they took blood samples from 44 healthy non-Hispanic men, white and non-HIV infected individuals. The research team isolated the DNA from these samples and analyzed all methylation patterns of the genome using molecular techniques.

The results demonstrated that the biological age of HIV-infected men on antiretroviral therapy is on average about 5 years ahead of their chronological age, resulting in 19% increased risk of mortality. In contrast, the biological and chronological ages of their healthy counterparts were closely aligned. All but 15 of HIV-infected men had some degree of advanced age, Ideker said.

"The beauty of this bookmark is that it is very fast, quantitative and conclusive," said Ideker.

Methylation data was what researchers and clinicians needed to validate the anecdotal observations that people with HIV age faster, Fox noted.

"The epigenetic clock of methylone predicts whether increased mortality or morbidity is accelerated and [our study] actually showed that this clock was advanced in patients with HIV," Fox said.

In addition to accelerated aging in HIV-positive individuals, Ideker and Fox team also found that the average rate of acceleration of age was the same regardless of how long the person had been infected with HIV, which was unexpected.

"I'm not entirely sure how to interpret this result," said Ideker, noting that perhaps the rate of advanced age is constant over time or, alternatively, trials do not have the power to detect subtle differences in age acceleration between those who were recently infected and those who had been infected for many years.

Viruses or drugs?

the HIV-VIRUS-facebook

What is not yet clear is whether this accelerated aging is due to the virus's own or long-term effect of antiretroviral therapy. Chronic inflammation resulting from viral infection may be leading to early onset of age-related morbidities in HIV-positive patients, noted Larry Corey, MD, Professor of Medicine at the University of Washington and past president of the Fred Hutchinson Cancer Research Center. Seattle. Corey directed the AIDS Clinical Trial Group in 1987.

"We know clinically that HIV causes a continuous inflammatory response," Corey said.

While it is possible that antiretroviral drugs may play a role in accelerated aging, Corey said that it is unlikely because this accelerated aging appears to occur among HIV patients, no matter which combination of antiretroviral drugs they are using. Instead, he suspects that reactivation of latent HIV reservoirs may contribute to the process.

In any case, it is a moot point because HIV is deadly if the patient does not take antiretroviral medication, Fox pointed out.

Another question that remains is what accelerated aging rate occurs among HIV-infected women and people of different racial groups, noted Carl Dieffenbach, PhD, director of the AIDS division of the National Institute of Allergy and Infectious Diseases, who was not involved with study.

"The aging of the woman is a bit more complicated with the effect of estrogen," said Dieffenbach.

directions Interesting

hiv

The study is solid and well done and points to HIV research for 'very interesting directions', commented Dieffenbach.

One finding with key clinical implications, Dieffenbach notes, is that human leukocyte antigen (HLA), genes that regulate the acquired immune response, have been hypomethylated in HIV-infected men.

"The direction this points us is that other diseases are associated with [HLA] hypomethylation?" Dieffenbach commented.

Researchers also found that hypomethylation is associated with HIV status and may be related to infection control and subsequent inflammation. The inflammation
caused by HIV infection, in turn, may be associated with the early onset of non-AIDS-related diseases such as cardiovascular disease and cognitive impairment in HIV-positive patients, Fox explained. He noted that this finding supports his overall conclusion that advanced biological aging predicts increased morbidity and mortality.

Another interesting question that the study raises, said Dieffenbach, is whether accelerated aging can be attenuated in people with HIV infection or if it is permanent.

"The virus, after taking the human body, establishes a path from which it can not recover or" change course "?" Dieffenbach said. "Even as the drugs got better and better, people with HIV infection show a deficit of 5 to 7 years in the expectation and quality of life."

Slowing the clock

HIV Virus

Along these lines, the results of this study may encourage ongoing lifestyle research and adjunctive pharmacological interventions, which could potentially delay the onset of age-related illness in HIV-positive individuals, Ideker noted. For example, a study currently underway is examining whether statins can reduce the risk of cardiovascular disease among HIV-positive adult patients aged 40 to 75 years who are having antiretroviral therapy without a history of heart disease (http://www.reprievetrial.org).

Editor's note: I showed the article about it to my doctor and she found reasons to prescribe statins me. "

atorlip-atorvastatin 20mg-10tab

The National Institute on Aging has called attention to the possible link between inflammation and age-related illness in people with HIV and is supporting studies of anti-inflammatory interventions such as aspirin and vitamin D (http://1.usa.gov/1SRXacL).

The study by Ideker and Foxsugere suggests that HLA genes may be a potential target of the drug to prevent the early onset of age-related diseases linked to chronic inflammation, Dieffenbach said.

"The hypomethylation of HLA locus is telling us something about how HIV changes the immune response, tilting the balance in favor of the virus", Dieffenbach said. Focusing on hypomethylation leading to a better immunity to HIV disease, as well as chronic diseases [such as heart disease] is a valuable drug target. ""As a family history of a certain disease, seropositivity of a patient should be seen as a major risk factor for other diseases, Fox said, requiring that doctors have "increased vigilance, increased prevention, and increased screening [for morbidities age-related]. "

Julie A. Jacob, MA

Translated by Claudio Souza Original in Men With HIV Age FasterAccording to DNA Methylation Study

Claudio Souza - Seropositive from 1994
That is the psycho-killer face

Review Bob Volpe (Tantum Nominum Nulum par Elogium)

beto

(*) Translator's Note: Early in the reading bumped into the term "Methylation". I concluded that without clarifying this point, even if pifiamente, I would be going against the tide and found the following : Methylation is the term used in chemical sciences to name the bond or substitution of a methyl group over several substrates. The term is commonly used in chemistry, biochemistry, science of alone and in the biological sciences.

In biochemistry, methylation refers more specifically to the substitution of an atom of hydrogen by the methyl group.

Em biological systems, methylation is catalysed by enzymes; such methylations may be involved in the modification of heavy metals, regulation of gene expression, regulation of protein functions, is RNA metabolism. Methylation of heavy metals can also occur outside biological systems. Chemical methylation of tissue samples is also a method to reduce certain artifacts of histological staining.

Source Wikipedia

Yes, this is the photo of me! My niece asked me to put this picture on my profile! .... I had here a description of me that one person described as "irreverent". This is really a euphemistic way of classifying what was here. All I know is that an "NGO" which occupies a building of 10 floors has established a partnership with me, and I have the logs of the partnership time, which was more a vampirism because for each 150 people leaving my site, clicking on them, there was, on average, one that came in. WHEN I ENTERED AND ENTERED

2 Comments

  1. Hello Mr. Claudio! .. Him greet with the Peace of God to Mr.!. I am grateful to God for your life and he estrategiado I get you your page in a constant search have been doing for over a year. five years me missing for my retirement in the new Law 85 / 95 ... (I'm 53 years and contribution of 25) I am HIV positive will 16 years, do treatment with antiretroviral there 10 years, thanks to God my membership was more than quiet, positive, I was never affected by any opportunistic disease ,. However suffer from depression since then, and even continuous treatment, I am now at a stage that no longer stand it do the same things, the routine of my work ... .etc ... take as many medications daily with the sum of psychotropic drugs and also ... all that was generated from contamination because I kept secret for thirteen years, and only God and I know how much it cost me and without even examining biological age I know how grown older my soul all these years .... but as Mr. I was blessed by God and married to three with a seronegative husband and I shared with him my stigma and now want to live in peace, take care of my home and always dreamed of my husband ,,, ,,, be voluntary etc ...... .In summary because I know your time is precious and you will meet many, after trying to find on the internet, I sought help from a lawyer and my infectious diseases ... nothing got, Dr. He claims to have no knowledge of such an examination I even handing printed matter ... and the lawyer said that without this examination, also has no argumentative proof ... .Enfim ... like Mr.. I help in the local research orientation in Brazil, that may or send material abroad for the examination referred to in this matter, to confirm my biological age, it would then be increased at least five years in my biological age, coming against my need to enter the judicial process application in Social Security for my retirement. I believe this attempt, and if I can, I believe in God so ... I could reverse my depressive state, which at the time me is more worrying that the positive ... for antidepressants take appetite me and I have had a lot of weight loss and therefore, you know better than I can the near future lower my immunity by lack of vitamins and nutrients, and then yes take risks with positivity. Thanks to God my CD4 is great and an undetectable viral load for years ... made my final exams this month, but for the first time in all these years I'm worried about the results that are not ready, due to the significant weight loss that had ... 20 kilos in three months. Today was more a lawyer and she was very enthusiastic about my initiative in this process, because we believe it is unprecedented, because the old deficit discovery also ... of 2015 until now, if I'm not mistaken ... .then took as a challenge that even if successful, it could help many other people ... .but we know that this examination is the fundamental argument for the interpretation of the Judge ... and still have their human interpretation will my favor, even scientifically, unfortunately this is a incontestable proof. Already, Sr.Claudio, I congratulate you for your deployment and attitude of life, and thank you very much for your attention. I'll be anxious awaiting a touch yours. May God continue to bless greatly Mr. and your wife ... good health, happiness and a fraternal embrace!

  2. Nanci Hello, sorry for the delay in answering, but I've been looking for what u asked me and I did not find solution.
    I think you should print this page and go to specialized health centers and seek what is needed. I would go further if you and would go to court with a request for an injunction that forced the CTA where vc is assisted to take the exam, even if they have to "import the technology."
    That would not be good just for you.
    If u win, and I have faith that win, TVZ u could give me documentation. I would create a new page with the non-personal data of its action and that opened doors for dozens, maybe hundreds, and ultimately deny the exam would cost so expensive for them that would eventually seeing forced to import technology and pass offer the standard way test "for any and every other individual in your similar situation.
    I remember a girlfriend, C. Carvalho, who on one occasion mentioned that the forest fire extinction until the hummingbird, carrying water on the tip of its beak, already make a big difference in the set in effort to end the fire

    Think about it

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