A note of Soropositivo.Org Editor.
The Click any price
Yesterday, Sunday, 02 2016 October, after waking up and take my coffee, I saw that my mailbox had been buried emails asking me if I knew anything about the patient healing (s) AIDS patients.
I know this exponential propagation of news where the Mornings of South Park publishes Eric Kartmann creates a new form of paste in school and, twelve hours later, on the other side of the World The Hong Kong Post announces in bold letters:
DEVELOPED SUPER ROUND TO PREVENT THE SEPARATION OF TECTONIC PLATES OF AMERICA AND EUROPE
Before thinking to answer I was to my sources, I I consider very serious, A few of them I've been following for the past ten years and saw nothing. Someone taught me to truly painful way that when in doubt, you must not exceed certain lines and remained silent.
But I browsed the Brazilian WEB and I had the bad feeling I have from time to time, which seems to me to be a liability, or a fetish, to get a click at any cost; and if the cost is based on Google's "pay per click, to me that's fine, it's money they're spending and it's not mine, in which case, damn it. But it is not at this price, it is with the cheap sensationalist currency what in the print media this is called "brown journalism"; And it seems to me that the click at any price does not care if the used currency is evaluated is the most expensive of all, even if this cost has to be calculated in loss of human lives that, as I learned recently, each person is a world and when it dies can leave wife, children, grandchildren, great-grandchildren, perhaps a second family at the other end of the airlift (...) etc.
I like to give good news, but with each passing week, every month progresses, each promising study I publish and results in nothing, I become more and more conservative, more selective, because when talking in HIV, AIDS and HEALINGYou may be determining destinations in directions the directions that would not be taken if I had been more prudentLike I went yesterday. I prefer to maintain trustworthiness and respect for those who come here, often with a painfully tight heart, receiving from me an often discouraging disillusionment about "gilding" a pill and leading, towards perfectly avoidable suffering, a group of people who always has the discernment to think that, even if it exists, it can take years and years to be available to more than thirty million people, like this image that I will show below, which has an emergency lack of new therapies that we are under HAART, with our controlled viral loads and our CD4 counts in good or medium condition. I believe that people, as I show below, have strict priority over us ... well, we can wait, and we will certainly be the ones who will be very close to the end of the line
A child, an orphan reportedly HIV positive in an orphanage near Chennai, near Madras, India abandoned by his family
If someone from another site come here and read this, my humble receive this message seriously, because we are all the same distance from death
A Sunday Times of yesterday reported That HIV had become undetectable in a man's blood after taking part in the study called RIVER, It is a study on an intensive treatment scheme developed for test whether it is possible to reduce levels of HIV-infected cells in the bodies of people newly infected with HIV. The researchers hope that treatment can eradicate the HIV infection completely.
The Sunday Times reported that British scientists are "of a cure for HIV infection". In fact, the study is still in its early stages and will not be able to describe the participants as "cured" until an extensive follow-up takes place and is carried out. Professor Sarah Fidler, a researcher at Imperial College, London, said to the Sunday Times that the study participants will be followed by five years. (Editor's note. This study, for example, already exceeds the vaunted forecast, in that video, a five-minute overproduction, promising cure for 2020.)
About the study RIVER
The study: RIVER is an acronym for 'Research in Viral Eradication of HIV Reservoirs' *** Investigation into the possible eradication of HIV Reservoirs *** - in free translation. The study is being conducted by the collaboration "the CHERUB Collaboration " a consortium of research teams at Imperial College and King's College, London, Oxford University and Cambridge University, funded by NHS National Institute for Health Research.
The study is recruiting people who have been infected with HIV in the previous six months - those who are known to be in "primary infection" which in this case may have fewer infected body cells at this time and, in theory, this group of people may be more conducive to complete HIV eradication or to stop antiretroviral therapy without causing a resumption of HIV viral load levels.
Study participants received a combination of four antiretroviral drugs including Raltegravir, which is included because it can lower HIV levels in the blood faster than other antiretroviral drugs. Aggressive antiretroviral treatment started during the primary infection has been shown to be effective in allowing the treatment to be completely discontinued without viral rebound in about 15% of people in a French cohort study called VISCONTI.
After 22 weeks of antiretroviral treatment, study participants are randomly selected to continue receiving ART with the four-drug regimen alone or to receive the antiretroviral regimen plus a vaccination designed to improve the immune response of HIV-infected cells . The participants in the present study will also receive ten doses of vorinostat, a drug that activates HIV-infected cells in those places known as hidden reservoirs, where HIV remains inactive and therefore imperceptible to the immune system.
If the experimental scheme is effective, vorinostat must "trigger" the mechanism of cells infected with latent HIV to produce HIV. The outbreak of the virus in production as a direct result of activation will be suppressed by the combination of highly effective antiretroviral drugs. Infected cells must be discovered by the immune system and vaccination should improve the immune system's ability to seek out and kill infected cells. This strategy, already known for some time, as "shoot and kill"Uses ten applications of vorinostat over 28 days - this was designed to "Wash the infected cells and kill them", leaving little or no HIV DNA remaining in the body.
The study is designed to test whether the approach effectively lowers HIV levels in the DNA of human cells, or even excising the infection completely. The study is measuring HIV DNA levels in the 40 and 42 the week after the start of treatment, but it is not a test to see if the treatment can be completely stopped after 42 weeks.
The study RIVER aims recruit 52 people diagnosed with the primary HIV infection. Recruitment takes place in clinics in London and Brighton.
What the study reported?
The Sunday Times reported that a study participant has no detectable levels of HIV after completing the study scheme.
This participant continues under antiretroviral therapy (ART).
this participant has not been cured of HIV infection at this point: prolonged follow-up will be required to determine whether the virus has been completely eradicated by the experimental treatment.
Professor Sarah Fidler of Imperial College, London, said to the Sunday Times"We will continue with medical tests for the next five years and at the moment, we are not recommending the suspension of ART, but in the future (five years ahead, reinforces the editor of Soropositivo.Org) depending on the test results maybe we can explore this step"
The RIVER study should not have complete testing of all participants until December 2017, as soon as possible, so that the results of the study will be available and likely to be reported in the first half of 2018. At this stage the researchers will be able to tell whether or not there was elimination of all traces of HIV in the DNA of participants in the experimental scheme. But the true test of an eradication scheme will have to be done to check what happens when treatment is stopped.
To date, the only person who appears to have been cured of HIV infection é Timothy Ray Brown,the so-called "Berlin patient who lost all evidence of HIV infection after a bone marrow transplant. A more recent study of similar bone marrow transplant recipients with HIV (to be translated) Identified that people who had undetectable and undetectable viral load of HIV in the DNA of their cells, have, however, experienced viral rebounds after treatment is discontinued – sometimes after a long interval. Long-term follow-up will be essential for anyone watching what happens to those who stop treatment in order to determine if HIV has truly been eradicated from the body. [Editor's note: In my modest understanding, with more than fifteen years of reading, translating, and following studies, it may be necessary to follow and monitor the health of these people for the rest of their lives to get to, to some conclusion that can be taken for granted in a science that, secondly, the doctors who have listened to me over the last 22 years, nothing is 100 percent reliable ...}]
If participants discontinue treatment after completion of the study, assuming that the regimen is successful in the evaluation statement that will assess whether of HIV DNA are undetectable, will be a matter of discussion between researchers and study participants and will depend on the best information available at that time on the consequences of discontinuation of treatment. In other words, it is too premature a report or a headline speaking in a breakthrough toward healing and who then say, headlines talking about HIV CURE.
Translated literally a matter of urgency by Claudio Souza, from the original Media reports of the British HIV cure 'breakthrough' are premature, written by Keith Alcorn and reviewed by Mara Macedo
For those who get here and want a little more realism, I invite you to click the below link and you will see that, somehow, to this day, since 1996 when did the combination therapy with three drugs, one being another inhibited protease, scientists say that since then, virtually little and almost nothing has changed since then
Reprinted on Tuesday made 04 October 2016
Originally published simultaneously in: 03 of October of 2016 by AIDSMAP (original source in English) and in Seropositive.Org in its Portuguese version of Brasil