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As HIV infection? As it leads to illness? ...

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The complicated and delicate process that HIV “uses” to make us sick?

Almost thirty years after the first cases of AIDS, we still don't know exactly how the HIV destroys the immune system (!!!). But inflammation - sustained immune activation - is now seen as a key factor in the process in which they do their damage, much like fire under the tundra. Research is reviewing how the virus is understood - and how it can be combated most effectively and forcefully.

Untreated HIV infection is evidently from the onset of the epidemic haphazard demonstrated that, sooner or later, HIV easily causes a massive loss of CD4 cells and the immune defenses of the human body. If CD4 cell count drops to sufficiently low levels and HIV unfortunately does so easily, the body becomes easy prey for opportunistic infections and cancers that the previously healthy immune system can efficiently and quietly defeat in the highest part of the time.

Perhaps, surprisingly, and yet not fully understood, the process as HIV depletes CD4 cells. In addition, while antiretroviral treatment has enabled people living with HIV to be able to stay healthy, with better white blood cell counts with the CD4 receptor, in all those who are medicated and have at least ninety-two adherence. five percent (in fact my membership is one hundred percent but it can still have its life overwhelmingly annihilated, people's lives are at risk of contracting or developing opportunistic infections, such as cytomegalovirus (CMV) retinitis, which can cause a person to lose vision and their ability to see becomes inferior in quality and acuity , and that can leave you completely blind, irremissibly and there is still, for example, Pneumocystis pneumonia (PCP), problems such as cardiovascular diseases (I, Cláudio Souza, suffered two pulmonary embolisms, one of which it was massive, as well as widespread kidney diseases.The toxicities of antiretroviral treatment - such as the increase in cholesterol - do not fully explain such complications: HIV infection itself is now understood to significantly increase metabolic risks.

Several emerging concepts may shed some light on these issues. The inflammation - the prolonged state of immune activation resulting from the ongoing immune system of battle with the virus - Seems to be a key factor in metabolic disorders and cardiovascular disease (my pulmonary embolism was triggered by these triggers). Research has also revealed that the digestive tract may play a much larger role in the progression of HIV disease than previously performed and, in fact, may be one of the strongest sources of immune activation.

early infection and intestines

intestines Sketch
That's you, your girlfriend, I… Omni Similis Summus

The course of HIV infection follows largely as a characteristic pattern for most people. During the first few weeks - acute infection - the immune system has not yet learned to respond to the new intruder. HIV levels are elevated throughout the body and the number of CD4 cells in the blood plasma drops dramatically. Tests now suggest that looking at only CD4 cells in the blood, which may have underestimated the overall measure of this early fall. Only a small fraction (2%) of the body's CD4 cells are actually found in circulating blood. Most live in lymph nodes (these include the 'glands' you can sometimes feel in the neck and inguinal region when you have an infection), in the intestines associated with lymphoid tissue (GALT Note to Translator, GALT is an acronym in English for the text marked in red above, which in English is defined as: Gut-associated lymphoid tissue ) where they are present as clumps of immune cell lining throughout the intestines in mucous membranes of other organs exposed to foreign substances such as lungs and genitalia. The researchers observed a massive loss of CD4 memory cells in this bowel tissue rapidly after infection. (Note: If I left here only the text with memory cells this would not be understood in its dramatic importance and the severe loss that this represents for us people living with HIV or AIDS. I searched the net and found on Wikipedia the following definition:

memory T cells are derived from other T lymphocytes that have learned to respond to a specific invader, for example a kind of bacterium, or a type of fungus or even a allergen and were successful in eliminating them. They go live for many years, and can be re-activated for a faster response to an attacker similar to the one they fought in the past. For example, a lymphocyte that has been activated to combat measles (by direct contact or by vacina) Can follow combating new invasions by the measles virus ensuring lifelong immunity to that individual.[9] At the end of this text you will find a link that leads directly to the entire Wikipedia page

Danny Douek, researcher at US National Institute of Allergy and Infectious Diseases (NIAID), studied the process closely:

“Since we thought CD4 cells were lost slowly but surely during the course of the disease. But we note that most of the outer memory T cells - which is most CD4 cells in an adult - are lost extremely quickly. ” About 60% of memory cells can become infected, and in most people it can disappear within the first two weeks of infection (…).

Ideally, the treatment of HIV might need protection against both pacing and immunodeficiencies. It is likely that this is a complex goal, and the consensus is that considerable research is still needed.

In Stripping (removal of internal layers of less virus) with tissue CD4 many cells, HIV also causes structural damage to the intestinal tissue, and immune to the lymph nodes where many immune cells normally reside. Recent studies have found that these tissues have become marked with collagen during infection aguda.2

Researchers speculate that this damage interferes with normal cell growth and cell interactions, limiting the ability of the immune system to fully regenerate CD4 cells lost in early infection. Intestines and tissue damage can also contribute to inflammation that helps lead to later stages of HIV disease - one point we'll return to.3

Chronic infection: Why CD4 cells die?

After the intense activity of a few weeks of acute infection, the body begins to produce antibodies and immune cells that specifically target HIV. During this period (known as seroconversion), viral load levels drop and the CD4 cell count returns to near normal levels. At this point, the disease enters a prolonged phase known as Chronic infection. (That's all you can say about “chronic disease” - AIDS is a syndrome that has little or nothing to do with chronic disease… AIDS does have everything to do with Acquired Immune Deficiency - AIDS in itself is not a chronic disease)

In the early years of the epidemic, the virus was even thought to sleeping during the long period of chronic infection. This proved to be completely wrong: the advent of viral load testing in the mid-proved that the virus continues to infect actively CD4 cells and other from the time of infection on, producing millions of new copies of every day.

Lymphatic and digestive system of Female body artworkIs it the virus that directly kills CD4 cells? It is easy to assume that this should be the main reason for the eventual drop in CD4 counts. But the truth is more complex. Considerably less than 1% circulating CD4 cells are actually infected with HIV during chronic infection - too few to explain the overall loss - and millions of new CD4 cells are created each day. In recent years, researchers have discovered possible other ways in which HIV leads to CD4 cell loss. These include toxic viral proteins, flashes from infected cells, which can kill uninfected cells in the so-called bypass effect. HIV can also trigger cells in "suicide" in a process called apoptosis., or programmed cell death.

Other mechanisms are likely to be at work well, including - ironically - the immune system's own response to HIV. The virus can infect only activated CD4 cells - those that have been “linked” to fight the infection. In other words, by the very act of taking action against the virus, CD4 cells themselves become targets for infection. This paradox is inevitable to some degree, since immune cell activation is an essential part of immune function. However, there is growing evidence that prolongation and excessive immune activation - inflammation - underlie much of the continuing damage from HIV disease.5

overtaking Immune

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One person already said something !!! And you will be left out!?

Cláudio Souza do Soropositivo.Org 26/01/2018 at 23:52:30

Well, I care about dozens, maybe hundreds of people, and it's not uncommon for every once in a while to come up with a foolish person who is afraid of the truth or who may have some fear of life and its truths, because if you read me give me a break from reading you will see and have to admit to yourself what my father once said to me when I lost my grandmother:

- "To die, just be alive"!

It is a great truth and that, yes, even a rude and sometimes cruel man can teach us something good!

And while this sounds shocking and even fatalistic, this is undoubtedly the only thing we take for granted in our lives, their end, our lives.

So I had to respond to a minor comment, a thought of a fragile spirit. And I decided to share this answer more broadly. everyone who can reach this page and decide to read it from this point:

Hello! You start by writing nonsense:

Hi, I read a couple of your articles. Well I couldn't read the rest, because the way you spoke gives a verdict that death is right, and it will come the worst way.

All deaths are right. This is the only unchanging certainty we have in life.

You also talk about a death that will always be the worst way.

Well, I remember that when I was about nine years old I was coming home from school and I heard, without giving it a damn about it, several Fire Department, Military Police, and ambulance cars drove by with the siren on. , but I didn't pay attention to these things. I was a boy of just over nine and knew nothing about life… or death.

That was when I realized close to home that there had been an accident, indeed an incident. A bus driver tried to cross the railway despite the signalman warning that a train was coming and, unfortunately, the bus was "picked up" by the train and tossed like a twisted metal ball dozens of feet away. But I was alone and went “closer” to “see better”.

And indeed I saw better:

In front of me, and at this moment, when I recall these memories, I realize that I can still see, there was a head, devoid of a body, right in front of me. I was terrified and thus paralyzed. An adult saw me there and drove me away. But the harm was done and I could never forget it.

Was this the death I ever saw?

I dont know.

I experienced HIV infection at a time when we did not have the modern treatments we have today and, indeed, no treatment at all; and I saw a lot of people perish in very painful and sad ways, but I won't describe these pictures, because I don't want to shake your head and scare you even more, because if the person tests themselves, and I think every person who relates sexually unprotected should, at least twice a year, be tested for HIV, hardly the worst…

Because we, those who are being treated regularly, who take our medicine regularly and correctly, are unlikely to die, except if it is God's Will, to die this way as you described it, the "worst form."

But ... Look. There are countries where there is still the death penalty and especially our “high level of civilization - we have smartphones and internet access right? - one of the ways you use to apply the capital punishment it's the hanging and I've heard reports of it and you who read me don't delude yourself! Hanging is a very crude process of execution, because this application of justice (…) takes more than 45 minutes to complete and this is a very sad way to die and is an institutionalized death, backed by the State , the Law and the Smile of those who, in one way or another, suffered the direct or indirect consequences of the actions of the sentenced.

Understand well. A person who does not test, who is not diagnosed, who lets say, say, the HIV infection runs wild (…), with his immunity (the CD4 count) is gradually and gradually dropping, may be surprised by a disease. Opportunist - There are those who delude themselves and people that people with HIV or AIDS can die from a simple flu, they already told me, they asked me if I'm not afraid to die from the flu… lol, lol… and that's why I created it a section of the site that deals with opportunistic diseases, so that all this is accessible and can be clarified. But I tell you:

"Yes, if a person is not treated, there is truly the risk of his life ending with a sad epilogue, if you can understand me."

Well, most people looking for me for zap are not formed, as I believed it would be, when I made my ZAP available to everyone, people desperate for their reactive results.

People come to me because of their real inability to not accept their "unreactive" results.

In this context, none of them showed me any fear of the future of their health.

99.9% of them fear the judgment of society, the fear of their parents, their friends. And… Unfortunately, this is a good (secondary) reason for your concerns because I, the DJ, full of girlfriends and an agenda with more than 250 contacts found me COMPLETELY ONLY when my diagnosis was “discovered”.

These people were of no avail to me and the path I followed is here on the site. Even people who loved me, and I believe they did, fraternally, could not live with this reality, despite the fact that they had wept in the dark light of my “new condition”, and they could help me… (…)….

The story is told here, on this site. And whoever wants, can easily find.

As for you and your difficulty reading until the end, I can understand.

There are many people who cannot live with reality, even if it is only and only in the field of illations.

Yes, I know, there are people who get scared easy on all intellectual and social levels and, I confess, I do have some fears, but I won't make them stated here, because they are for the people closest to me, that deserve to have their names saved in my contact list on the Whats App and, I attest and give faith.

Few people can look at the consequences of their actions, I chose to contract HIV when I began to relate systematically without condoms, and today I had lunch with a friend I notified, twenty-some years ago that I was with HIV. My childhood nickname was Bigfoot, but this friend of mine calls me "Foot."

And he said to me:

  • Damn foot! And I said
  • “Dude, living the way I lived could only do that”!

And it's true. Me, and many people living with HIV today because they “forgot about“ self love ”(there are other ways to get HIV and I talk about myself and people who are or were like me), to take care of themselves and now in their devastating majority, are no longer in this world.

Anyway, lady, read the text to the end or click at this address and be happy 🙂 🙂 🙂 😉 😉 😉

And here we have this answer

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