Well, since I have been living with HIV for 22 for years, it is to be expected that I will meet some doctors, most of whom are respected and others who are anonymous, who have been on the front line for so long that it could be said that "they have seen everything" . But they and they, my doctors, know that there is still much to see and the best is yet to come.
I asked a friend, also a medical infectologist, who has been dealing with HIV and AIDS for so long that I putz cricket.
She left me this text through one of my channels of communication and I reproduce here, Ipsis literis and I take responsibility of the publication for myself and, sir, I respect the privacy of the people who help me in the task of conducting this work.
Well, having said that, I open the way to a person with a well-regarded view of AZT and all that it has generated!
Good night, Cláudio,
I find it very interesting to see how the development of anti-HIV medications has boosted medicine. But we have to think that it was necessary to isolate HIV in 1983 for the opening of the antiretroviral era.
Viral isolation has enabled the world to see AIDS in its proper proportion, a viral disease that affects the immune system, Gay plague Or other preconceived ideas of "Divine punishment".
The characterization of the viral cycle and the ability of reverse transcription of the virus from RNA to DNA were the steps that enabled the study of zidovudine as a potential drug for treatment. It was a polymerase inhibitor synthesized in 1964 for the treatment of cancer.
In 1983 the US National Cancer Institute launched a program to look for potential HIV drugs in pharmaceutical libraries. Groups of researchers have started to research in particular drugs with potential action against reverse transcriptase.
From experimental studies of 1984, which observed antiviral activity of zidovudine "In vitro", Clinical trials that observed effective antiviral activity in patients with HIV / AIDS infection were started.
In 1987 the study was published "The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial " In the New England Journal of Medicine, which culminated in the approval of zidovudine by the FDA.
It is important to realize that this was initiated by zidovudine, with subsequent development of other antiretroviral medications, has revolutionized the way we deal today with not only HIV / AIDS infection but also other viral infections. I remember the day-hospitals crowded with AIDS patients and severe opportunistic infections in the early years of the 1990 decade.
Since then, day hospitals have all been closed for lack of use.
If today we have direct action antiviral drugs against the hepatitis virus as well, if we have direct action antiviral drugs against hepatitis B virus and hepatitis C virus, we have to thank the initial success of zidovudine.
In turn, perhaps these new steps lead us to the treatment of arboviruses such as Zika fever or yellow fever, hepatitis C, we have to thank the initial success of zidovudine.
Sigrid from Sousa dos Santos
Medical Infectologist for 22 years ago
It has been "my Infection" for over ten years