Taking dolutegravir in the morning may prevent insomnia

Dolutegravir and Insomnia

Editor's note: Do not take the initiative to change your medication schedules based solely on what is written here. When little you can show this page to your caregiver and ask him if this is possible in his current condition and talk to him / her in this regard. I'm not a doctor and I can not get over my head to Sword of Damocles on account of their personal initiatives. I reinforce: CONVERSE WITH YOUR PHYSICIAN / MEDICINE.

Italian doctors say that insomnia, after taking the integrase inhibitor, dolutegravir, occurred less often when patients took the dose of the drug in the morning.

Insomnia has been reported as a common side effect of dolutegravir, affecting at least one in a hundred people who take the drug as part of an antiretroviral combination. Nausea, diarrhea and headache are reported much more frequently than insomnia, but for those who experience it, insomnia can affect the quality of life.

Insomnia is something that the publisher of this site has the right and wrong and neither do dolutegravir


Several recently reported studies have shown that neuropsychiatric side effects - especially insomnia - appear to be common in people taking dolutegravir. Um estudo que analisou os efeitos colaterais em pessoas que iniciaram o tratamento à base de inibidor de integrase na Alemanha found that neuropsychiatric side effects that were severe enough to lead to discontinuation of dolutegravir were more common in people with 60 years and older in women and in people taking dolutegravir in combination with abacavir.

Italian researchers report in a letter to the journal HIV Medicine, that in three quarters of cases, patients reporting insomnia after starting treatment with dolutegravir, found that the problem stopped when they changed the dosage at night for morning dosing.

The Italian researchers, who treated patients at clinics in Northern Italy and Rome, started 1502 patients on dolutegravir since June of 2014. Of these, 3,5% (52 patients) reported insomnia or sleep disorders. Insomnia was more common in women and in older patients, but was not associated with the use of abacavir in this patient population.

After switching to morning dosing, insomnia disappeared in three quarters of the patients, but remained a problem for 13 in 52 (25%), and eight patients finally discontinued the drug as a result. In four of the eight patients who discontinued treatment, additional adverse events such as agitation, dyspepsia or reduced libido contributed to the decision to discontinue treatment. dolutegravir.

Switching to morning dosing did not give rise to new side effects in most patients, although three have reported some anxiety or irritability after switching.

Switching to the morning administration can generate problems for some people who need to take dolutegravir with food. Foods increase blood levels of dolutegravir, so taking the drug with food is recommended for anyone who has resistance to an integrase inhibitor. The higher the fat content of the meal, the greater the increase in drug levels.

People taking dolutegravir should avoid taking the medicine at the same time of day, such as magnesium-based or aluminum-based antacids, iron or calcium supplements, or multivitamins. Prescription counseling recommends that dolutegravir be given two hours before or six hours after taking these agents.

Keith Alcorn

Publication: 31 August 2017

Translated by Cláudio Souza from the original in Taking dolutegravir in the morning may avert insomnia

Reviewed by Mara Macedo


Capetti AF et al. Morning dosage for disorders related to sleep and insomnia-dolutegravir. Medicine against HIV, advanced online publication, 1 August 2017.

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About Claudio Souza do Soropositivo.Org (508 articles)
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2 comments on Tomar dolutegravir in the morning can prevent insomnia

  1. My name is Thiago, I have 36 years, I took Dolutegravir by prophylactic measure, I started to have insomnia and great anxiety and disorders, first I did not know what was happening to me, since I had not had this before, after a few days I went to Google research on medication, I saw that was introduced a short time in Brazil and that in the Netherlands 14% of people who took discontinued treatment with it because they felt side effects such as: insomnia, anxiety, psychosis, and others ... 14% is a very large index, and more, the bull cake of suicidal disorders! Then imagine the reaction of people who are often homosexual, who do not have a certain support of the family and with other problems take this medication, in fact, I think the doctor needs to talk more with patients about these adverse effects.

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