The HIV Life Cycle

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Acute HIV Infection! What is It?

You see, the life cycle of HIV, In a person who is not being treated it is something that happens, depending on the viral load of the carrier, which is growing exponentially and, exponentially, the life cycle of HIV replicates and self-exponents.

See this, it's an image resource available to everyone! And it shows the tenacity and voracity of this life cycle of HIV through Wikipedia! But…

What Guarantees the HIV Life Cycle The HIV-infected CD4 cell is a perpetual motorcycle where, in the unconscious way of living, HIV ends up killing the host.
Scanning electron micrograph of green-colored HIV-1 emerging from a cultured lymphocyte.
Photo Credit: C. Goldsmith Content Providers: CDC / C. Goldsmith, P. Feorino, EL Palmer, WR McManus - This media comes from the Centers for Disease Control and Prevention's Public Health Image Library.With identification number #10000. Note: Not all PHIL images are public domain; be sure to check copyright status and credit authors and content providers.
Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocyte. This image has been colored to highlight important features; see PHIL 1197 for original black and white view of this image. Multiple round bumps on cell surface represent sites of assembly and budding of virions.
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The text below was created by Greta Hughson on November 2017 on AIDSMAP. The text was translated faithfully and during the review I insert my personal considerations from a layman who has been working on this 19 for us on this blog and, yes, I believe I have learned a little and yet I am not a doctor or scientist. Only one person living with HIV for almost a quarter of a century!

Initially, you need to note these points:

Main points

  • The immune system is the body's natural defense system.
  • To survive, HIV needs to infect cells in which new viruses can be created.
  • Different anti-HIV drugs target different stages in the process of replication by HIV-infected cells.

ART, we establish here, is Antiretroviral Therapy, a treatment with medication that is generally known as “cocktail”

Therefore, antiretrovirals (ARVs) interfere at these life-cycle points and, for the record, it is much cheaper to treat people with HIV than to treat them when, finally and disastrously, AIDS sets in and it is necessary to treat them. opportunistic diseasesunless, as proposed by a Rio Grande do Sul health secretary, “it is not worth treating people living with HIV because they will really die!

The fact of being sick does not represent death and death is something that awaits us all around the corner.

The link to the text is above and the text itself is the work of a brilliant Jurist, Sandro Sardá and I paste this excerpt below and highlighted just to inform you initially that I disagree with the highlighted text, and I can write about it , if you wish, there is a poll for me to know your desire in 30 days! I disagree with:

HOWEVER, TODAY THE PROCESS OF “COOPTATION” BY THE STATE OF OLD LEADERS AND SEROPOSITIVE PEOPLE WORKING ON THE MUNICIPAL STD / AIDS PROGRAMS, WITH IMPORTANT VICTORIES FOR MOVEMENT.

Going back, I feel like I've broken lines, but this grudge-writing thing grabs and doesn't come out, except with the help of Seven Exorcist😜😪….

The human immune system protects the body. It is made up of many different cells that are scattered throughout the body, each playing different roles and moving around the body as needed. The fact that they are white does not mean that leukocyte counts on a bloody blood count, as one stupid doctor with a medical degree said.

I bet she got the diploma, made a cushion and sat on it.

Blood Cells

There two main types of blood cells. The most common are red blood cells or erythrocytes, which carry oxygen to body tissues and carry carbon dioxide back to the lungs, where miraculously "exchange" occurs and carbon dioxide is returned to the atmosphere and, with this, 17, of the 21% Oxygen we inspire. Keep this number, if one day you are buried, but vivid, the oxygen will surely decrease, but little by little. Keep calm and breathe slowly….

The other group are white blood cells or leukocytes. These are the cells of the immune system.

It is estimated that around 10,3 Billions of New Viral Particles (Viruses, trying to explain this is going crazy and driving you crazy to be produced every day in people who are not being treated for HIV..

Some white blood cells recognize specific foreign organisms to which the body has been exposed in the past. These specific immune cells are called lymphocytes. Other white blood cells are nonspecific and can attack a variety of different foreign organisms: these include neutrophils, eosinophils and natural killer cells.. (CTHA, by God!….)

Lymphocytes

There are two different types of lymphocytes.

B lymphocytes (sometimes called B cells only) produce antibodies. An antibody is a protein that can block in a distinct part. of a specific foreign organism.

For example, there are broadly neutralizing antibodies to block CD4 protein, but it only appears years, years and years after infection!

And yes, but unfortunately, many studies have been done in order to create a vaccine from them but, until today, 20 August 2019, there was a lot of hope, a lot of expectation and frustration.

The Fight Continues and the Search for the Healing Continues! But Use Wisely When Thinking About It.

This way, when this happens, the antibody signals other cells in the immune system to attack the body.

T lymphocytes (sometimes called just T cells) are called different names, depending on the molecules on their surface. CD4 cells, also known as CD4 T lymphocytes or helper cells.

T lymphocytes CD4 - Differentiated typing !!!

"Watch: Lymphocytes T CD4! ”

It's a LYMPHOCYTE TYPE and lymphocyte measurement can't, as some moron did, “Foreshadowing AIDS”) play a coordinating role in the immune system.

They help B lymphocytes identify foreign organisms (against which they produce antibodies). They also secrete substances that allow CD8 cells to reproduce.

CD4 cells also activate macrophages (see below) to kill certain organisms, including many of the organisms that cause AIDS-related illnesses. When the CD4 cells are destroyed by HIV, all these parts of the immune system are disrupted. CD8 cells (also known as CD8 T lymphocytes or cytotoxic T cells) bind to abnormal body cells, notably cells that have been infected with viruses, and kill them.

Other immune cells

This excerpt to Text speaks of God's Magnanimity and the Perpetual Show which is Creation Associated with Evolution! The Time the Lord of Waiting Works for Things for Itself to Reach the “exact point of the project ”me show how much patience He has for us and, quoting Bezerra de Menezes, “what is thirty years of confrontation before the Eternity Panel!? !!!!!!!!!!!”

Natural killer cells (or NK cells) attack tumor cells and virus-infected cells in a similar way to lymphocytes.

But while each lymphocyte can only recognize and attack cells infected by a specific virus, natural killer cells can attack a wider range.

God Is Fantastic

Eosinophils attack organisms that are too large to be eaten by a single phagocyte, such as worms.

Phagocytes are cells that attack and destroy foreign cells by swallowing them. There are two main types of phagocytes:

  • Macrophages travel through the body's blood and tissues (it is independent of the bloodstream and "navigates" through the tissues, killing organisms that can cause AIDS-related illnesses and virus-infected cells. Or Not !!!
  • Neutrophils leave the blood to go to the tissues where infection or inflammation is developing. They mainly attack bacteria and fungi.

HIV is a virus! The Human Disability Virus

HIV is a virus. The viruses are germs (In a way, they are not living things, and insanely, they are very specialized in the art of survival and yet, however, they are unable to reproduce (replicate) themselves. Instead, they need to find and infect a functioning cell. as a host on which new viruses can be created.

When HIV is out of a cell, it is known as virion and is surrounded by a protective envelope. The envelope involves several viral proteins and some genetic material - a "blueprint" containing all the information needed to create new viruses.

Viruses can be divided into two forms: those whose genetic material is made of DNA, and those whose genetic material consists of RNA (such as HIV). RNA viruses are called retroviruses. HIV is a retrovirus and the reproductive process of HIV and other retroviruses involves an additional step that is not necessary for DNA viruses.

Fusion

Viruses usually have a specific cell in the human, animal or plant host that they particularly like to infect. The main HIV-infected cells are those that contain a molecule called CD4 on its surface. CD4 is found in immune cells, particularly helper T cells and macrophages.

HIV enters these cells by binding to the CD4 receptor using a molecule on the surface of the virus called gp120. Since HIV binds to CD4, it activates other proteins on the surface of the human cell, known as CCR5 and CXCR4, to complete its fusion with the cell.

Reverse transcription

Once fusion has occurred, the interior of the virus (RNA and some important enzymes) is absorbed by the human cell. A viral enzyme called reverse transcriptase performs the process necessary to translate HIV genetic material (RNA) into DNA.

Integration

The newly formed viral DNA is then integrated with human host cell DNA using a viral enzyme called integrase. This allows HIV to reprogram the human cell to produce more HIV.

Transcription

At this stage, the two strands of DNA divide and form a new strand of viral RNA, sometimes called messenger RNA.

Translation

Then the protein building blocks, which will form the new HIV particle, are assembled within the human cell. These blocks are arranged in turn by translating the information contained in the messenger RNA.

Viral mount

The protein building blocks are then cut into smaller pieces by a viral enzyme called protease. These pieces form the structure of the new HIV particle, including each of the enzymes and proteins needed to repeat the reproductive process. Once this assembly has occurred, the new viral particle detaches from the human cell, floats in the bloodstream and is able to infect other cells. It is estimated that about 10,3 billion new viral viruses are produced every day in people who are not treated for HIV.

HIV Treatment: Antiretroviral Therapy:

Different types of anti-HIV drugs target these different steps.

How the treatment works is on my “! Editing table” and should be ready in a week, maybe two

This page should be reviewed in November from 2020.

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