Injectable Antiretrovirals Every 8 Weeks was something I published firsthand on 2016. about studies on 2016 Injectable Antiretrovirals in the article whose header I published above and the excerpt pasted below.
From 2016 Matter
- 1.1 Tests will evaluate the safety of bimonthly injection after certainty in monthly therapy!
- 1.2 Most Common Reaction Was Injection Site Pain 😉
- 1.3 Tell your friends! If you do not like it ... Tell it to enemies 😉
- 1.4 Like this:
- 1.5 Related
De Maintenance therapy with cabotegravir and rilpivirine Injectable Antiretrovirals works equally well when given monthly or every two months.
A combination of two injectable antiretrovirals, cabotegravir and rilpivirine, is equally effective in maintaining viral suppression when given once a month or every two months, the companies developing the long-acting regimen announced.
“The results of the ATLAS-2M study mean that people living with HIV they can maintain viral suppression with six total treatments a year instead of a daily oral treatment 365 times a year, ”said Kimberly Smith, MD, head of global research and development at ViiV Healthcare.
Tests will evaluate the safety of bimonthly injection after certainty in monthly therapy!
The formulations ViiV integrase injectable antiretrovirals, Cabotegravir, in addition to Janssen non-nucleoside reverse transcriptase inhibitor, Rilpivirine (sold in pill form as Edurant) have been studied both in people who have switched from standard oral antiretroviral therapy with viral load undetectable as in those who started HIV treatment for the first time.
As reported at this year's Conference on Retroviruses and Opportunistic Infections, results from the ATLAS Phase III study showed that 92,5% of people randomly assigned to switch to the injectable regimen had undetectable HIV (less than 50 copies) 48 weeks later, as well as 95.5 % of those who remained in their oral regimen.
I see here a possible hypothetical minority in the damage to the labor relationship, if there is anything left of it !!! (…)
Similarly, the FLAIR study showed similar rates of viral suppression in people new to treatment, 93,6% and 93,3%, respectively.
In both studies, treatment with injectable cabotegravir and rilpivirine was generally safe and well tolerated, and serious adverse events were rare.
Most Common Reaction Was Injection Site Pain 😉
The most common side effects were injection site reactions such as pain and swelling, but these were typically mild to moderate and decreased over time.
The results of the study presented at the International Conference of the Society of AIDS This summer's HIV Science in Mexico City showed that people taking the injectables reported a high level of satisfaction with their treatment and preferred them to daily oral medicines.
In these studies, cabotegravir and rilpivirine were administered by health care providers as two separate intramuscular injections, preferably in the buttocks.
Participants were asked to return to the clinic each month within a seven-day window. Adherence was good in both studies, with almost all receiving monthly treatment within this window.
However, returning to a clinic for injections every month can be inconvenient, and receiving treatment less often would be attractive.
The ATLAS-2M phase III study was a direct comparison, in which participants were randomly assigned to receive cabotegravir and rilpivirine injections every four weeks or every eight weeks.
They had no history of previous treatment failure. 😯🙄😔
This international study included 1.045 people with HIV who were on their first or second antiretroviral regimen, had viral suppression for at least six months and had no history of previous treatment failure.
ViiV and Janssen announced in press releases that the study achieved its primary goal by showing that the efficacy of the injectable cabotegravir / rilpivirine combo was similar at 48 weeks, regardless of whether it was administered once a month or every two months.
In other words, cabotegravir / rilpivirine administered every eight weeks was found not to be inferior to administration every four weeks.
The companies did not provide viral suppression rates or other detailed data at the time, indicating that they would be presented at an upcoming scientific conference.
“We are excited to report that for the first time since the HIV / AIDS epidemic began more than 30 years ago, our ATLAS-2M study has shown that it is possible to maintain HIV suppression with an injectable regimen containing two medicines given every two years. months, ”said Smith.
"Approval of this regime would mark a significant change in the HIV treatment paradigm."
In the wake of this, on 2017, I published it (controversial theme inside this really hard head of mine) Injectable PrEP may be on its way!
And Because History Matters, the Beginning of Study