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Atripla! Three HIV Medications in one pill!

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Single Pill Regimens

Atripla

Generic Name: efavirenz + tenofovir disoproxil fumarate + emtricitabine

Medication class:

Company: Bristol-Myers Squibb and Gilead Sciences

Approval Status: approved

Generic version available: yes

Medicine indication

An alternative treatment regimen for people who are virgin to antiretroviral therapies living with HIV, as directed by the US Department of Health and Human Services (DHHS)

General information

Atripla is a single pill regimen for HIV. It contains two different types of HIV drugs: a non-nucleoside reverse transcriptase inhibitor and two nucleoside reverse transcriptase inhibitors. Atripla was approved by the US Food and Drug Administration for use by people living with HIV in July 2006. THE

Atripla is a combination of three medicines: Sustiva (efavirenz), Viread (tenofovir disoproxil fumarate) and Emtriva (emtricitabine). All three medicines can be purchased individually for use in combination with other HIV medicines.

Dosage

Adult dose: One tablet once a day. Each tablet contains efavirenz 600 mg + tenofovir disoproxil fumarate 300 mg + emtricitabine 200 mg.

Pediatric Dose: 12 to 18 years old and weighing at least 88 kg (40 kg): one tablet once a day.

Dosage Information: This is a complete one-pill regimen once a day. Assume an empty stomach. The dose should be taken at bedtime to minimize dizziness, drowsiness and decreased concentration.

Collateral effects

A lot, but a lot of attention even the next stretch !!!

Many patients experience dizziness, headache, difficulty sleeping, drowsiness, difficulty concentrating and / or unusual dreams after starting treatment with Atripla. These feelings may be less insistent if you take Atripla at bedtime on an empty stomach. They also tend to disappear after you take the medicine for a few weeks. Tell your doctor immediately if any of these side effects persist or bother you.

A small number of patients experienced severe depression, strange thoughts or angry behavior while taking Sustiva, one of Atripla's medicines. Some patients had suicidal thoughts and some actually committed suicide.

These problems tend to occur more frequently in patients with a history of mental illness. You should contact your doctor immediately if you think you are experiencing these symptoms so that they can decide whether to continue taking Sustiva.

Rash is another common side effect of Atripla. These rashes usually disappear without any change in treatment. In a small number of patients, the rash can be severe. If you develop a rash, call your doctor as soon as possible.

Renal insufficiency

Atripla can lead to new or aggravated kidney problems, including kidney failure. Your doctor may perform blood tests to check your kidneys before and during treatment with Atripla. If you develop kidney problems, your doctor may need to make changes to your treatment regimen.

Atripla can lead to bone problems, including bone pain or soft or thin bones, which can lead to fractures. Your doctor may do tests to check your bones.

If you also have hepatitis B virus (HBV) and take Atripla, your hepatitis may get worse if you stop taking it. Do not stop taking Atripla without first talking to your doctor.

Drug Interactions

On the day before your appointment make a list of everything you take. No matter how insignificant and "everyday" it may seem to you to be a pedicure. There are antipyretics that lower the pressure. If in the middle of your appointment the doctor tells you that she will give you a medicine to keep your blood pressure down, if you are hypertensive, at least ask her what alternatives you have if you have a fever (watch out for a fever that comes from a delirium) psychological or paranoid).

These medications should not be taken with the following medicines while being treated with Atripla®:

  1. Antibiotics: Priftin (Rifapentin)
  2. Antifungals: standard doses of Vfend (voriconazole)
  3. Antihistamines: Hismanal (astemizole) or Seldane (terfenadine)
  4. antipsychotics: Orap (Pimozid)
  5. Acid Reflux / Heartburn Medicines: Propulsid (Cisapride)
  6. Heart Drugs: Vascor (bepridil)
  7. Sedatives: Versed (midazolam) and Halcion (triazolam)
  8. Antimigraine medications: Wigraine and Cafergot (medicines for ergot)
  9. Antivirals: Hepsera (adefovir)

Atripla should not be used at the same time as Vfend (a voriconazole), a medicine used for certain fungal infections. Efavirenz in Atripla may significantly decrease the effectiveness of Vfend; Vfend may significantly increase the risk of efavirenz side effects.

Atripla should not be combined with any HIV medicine that contains any of the active ingredients in Atripla. They include: Complera, Emtriva, Genvoya, Stribild, Sustiva or Viread. The combination of Atripla with HIV medicines containing active ingredients similar to Atripla should also be avoided. They include: Combivir, Epivir, Epzicom, Rescriptor, Triumeq, Trizivir and Viramune.

Other medicines that can be avoided during treatment with Atripla: Fortovase, Invirase (saquinavir), Biaxin (clarithromycin), Noxafil (posaconazole) and Sporanox (itraconazole).

Important drug interactions for hepatitis C treatment: May be combined with Sovaldi (sofosbuvir), Harvoni (ledipasvir / sofosbuvir), ribavirin and pegylated interferon alfa. Do not use with Olysio / Sovriad (simeprevir) or Viekira Pak (ombitasvir / paritaprevir / ritonavir / dasabuvir).

Dosage modifications of the following medicines may be required if combined with Atripla: calcium channel blockers such as Cardizem or Tiazac (diltiazem), Covera HS or Isoptin (verapamil) and others; Crixivan (indinavir), Selzentry (maraviroc); immunosuppressive drugs cyclosporine (Gengraf, Neoral, Sandimmune and others), Prograf (tacrolimus) or Rapamune (sirolimus); Methadone; Mycobutin (rifabutin); Rifampicin; cholesterol-lowering medications such as Lipitor (atorvastatin), Pravachol (pravastatin) and Zocor (simvastatin); or the antidepressant drugs bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL and Zyban) or Zoloft (sertraline).

Other drug interactions are possible. See the Atripla brochure for more details: http://packageinserts.bms.com/pi/pi_atripla.pdf

Further information

Before taking this medicine, tell your doctor if you have kidney, liver disease (including hepatitis B) or a history of depression / suicidal thoughts. Also, tell your doctor if you are pregnant or planning to become pregnant, if you are breast-feeding and all your medical conditions, including all prescription and over-the-counter medications and supplements.

Patient Care Program Information: https://www.poz.com/basics/hiv-basics/drug-assistance-programs

Translated by Claudio Souza from the original POZ in Atripla No information about author or editor of text

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