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Capisacin Promises to Treat Neuropathic Pain

Capsaicin
It hurts for chayote
Capisacin in patches helps to mitigate pain from peripheral HIV neuropathy, difficult to control according to news Ed Susman, reporting that…

… Capisacin patch is hope of relief from Peripheral HIV neuropathy

Capisacin patch relieves pain

An 8% capisaicin patch (NGX-4010), the researchers said. Patients reported an average 27% decrease in their Numerical Pain Rating Scale if they were treated with 8% capsaicin compared to an average 15,7% reduction with the use of 0,04% capsaicin, an active control, said Stephen J. Brown, MD, of the AIDS Research Alliance in Los Angeles.

Capisacina action points

  • Note that this study was published as a summary and presented at a conference. These data and conclusions must be considered preliminary until they are published in a peer-reviewed journal.
  • Explain that HIV-associated neuropathic pain appears to be relieved for at least three months with a single 30-minute application of an 8% capsaicin patch.
  • Note that the most common side effects were pain and erythema at the application site, transient and resolved spontaneously in one week.

Pain has no measure. But…

This difference resulted in a significant reduction in pain scores (P= 0,0026), he reported at the annual meeting of the American Academy of Pain Medicine. “More than half of people with HIV infection develop neuropathy”And about 30% to 40% of them have painful neuropathy“Brown said to MedPage Today in your poster presentation. This is one more reason, I reinforce, to look for an authentic end to AIDS "So far, the drugs used to treat neuropathic pain have yielded disappointing results in large, randomized controlled trials among HIV-associated neuropathy." The only substances that have shown an impact on pain appear to be the 8% capisaicin patch, smoked cannabis and the recombinant human nerve growth factor - but none of these treatments have been approved by the FDA for this use, Brown noted. Brown gathered data from two randomized controlled trials, in which 239 patients were treated with 8% capsaicin and compared with 99 patients who received active control - a stronger capisacin treatment than capsaicin, a medicine derived from hot chili. The patients were evaluated three months after applying the capsaicin patch.
Both studies were sponsored by NeurogesX of San Mateo, Californiaa.
The company is seeking an indication for the treatment of HIV-associated neuropathy with the patch, which is approved for other indications of neuropathy. Patients were treated with 4% lidocaine for 60 minutes before applying the patch. The treatment can be painful (!!!) (???) And? Worse is sitting at two in the morning, translating that. And it's self-care too "This treatment can be painful," said David Walk, MD, of the University of Minnesota in Minneapolis. Walk has worked in other studies with the 8% capsaicin patch, but was not involved in Brown's HIV study.,
Not even with lidocaine
“Even with the lidocaine that is delivered before the patch is applied, patients report some pain associated with the patch for as long as a week later, so they usually send them home with pain relief to cover that period, Dr Walk said MedPageToday.

He said he prefers this application to be carried out in the office, to ensure that the patches are positioned and applied correctly and to treat any acute pain that may occur.

In Brown's study of HIV patients, about 36% of them also reported a 30% reduction (each 0.1 counts….) Or more on the Numeric Pain Reporting Scale, compared with 22% of patients in the active control (P= 0,0051).
Very efficient Capisaicin
About 37% of patients on the 8% capsaicin patch reported a greater than two-point reduction in pain score compared to 24% of those who received the active control agent(P= 0,0284). In the patient's overall view of his pain impressions, something devilishly damned, about 36% of patients who applied capsaicin reported that their pain impression had improved a lot or “paid off the bill (😉) much improved compared to 22% of patients in active control (P= 0,0162), Brown reported.
Twelve Weeks !!!!!! Twelve….
“These integrated analyzes show that a single application of NGX-4010 from 30 minutes can reduce neuropathic pain due to HIV-associated neuropathy 12 weeks“…. Twelve, twelve weeks, said Brown! Brown said that 98% of patients were able to tolerate at least 90% of the intended duration of adhesive application.
Side Effects Were Transient
The most common side effects were pain at the application site and erythema. These mild to moderate adverse events were transient and resolved spontaneously within a week, Brown said. Capisacina is a great promise "I think this patch holds great promise in relieving Neuropathic Pain associated with HIV infection," said Erik Shaw, DO, of the Shepherd Pain Institute in Atlanta, to the MedPage Today. “This is an application and appears to be effective for at least three months. I think we will see more use of this patch in other conditions of neuropathy ”. Disclosure
Brown's study was sponsored by NeurogesX.
Walk has disclosed financial relationships with Eli Lilly and Company, Pfizer, Aldoc Pharmaceuticals, AstraZeneca, Johnson & Johnson and NeurogesX. Shaw disclosed financial relationships with Azur, NeurogesX, Boston Scientific and Forest Laboratories. Originally translated into AAPM: Capsaicin Patch Eases HIV Neuropathy Pain primary source American Academy of Pain Medicine Source reference: Vanhove G, et al. “Effectiveness of NGX-4010 (Qutenza), an 8% capsaicin patch, applied for 30 minutes in patients with HIV-associated neuropathy: results of integrated analyzes” AAPM 2011; Summary 139.

If you need to talk and couldn't find me or Beto Volpe, this is a much more balanced option, Beto, you can also send your message. Maybe I can take a while. I check the messages at noon, shortly after, in fact, at 20:00.
It's getting harder and harder for me, this whole thing, to type.
And I end up needing an interval between one paragraph and another.

But be sure of one thing I learned:

Time and patience solve just about everything!
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