Adults With HIV: Longer Life! But Complicated!

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AIDS Oral Sex And The Facts

Adults with HIV live longer if there is an early start of antiretroviral therapy in HIV patients with apparent normalization of life, only apparently normal! Only those who spend one day after another, with nights in between, know that…

… Adults with HIV live longer, but not as healthy!

Early initiation of antiretroviral therapy (ART) in HIV patients appeared to normalize life expectancy when they had high CD4 cell counts, the researchers found.

A difference of less than three years was observed between HIV-infected adults in successful ART and uninfected control subjects, based on data analyzed between 2014-2016, reported Julie Marcus, PhD, from Harvard Medical School in Boston.

However, a 16-year gap remained free from comorbidities, she reported. at the Conference on virtual retrovirus and opportunistic infections (CROI).

Marcus noted that ART has dramatically increased the life expectancy of people living with HIV, with improved treatment, meaning that gaps in life expectancy continue to decline among people living with or without HIV.

His group decided to quantify how long this period had decreased and how many of those years of life “Were healthy” Or without comorbidities for these populations.

They examined data from the Northern California axis and mid-Atlantic states between 2000 and 2016, with 1:10 frequency matching for infected individuals and uninfected controls on age, sex, race / ethnicity, care doctor.

In Frigir of Eggs Comorbidities Complicate Everything!

In addition, they examined data on specific comorbidities, such as chronic diseases of the liver, kidneys and lungs, as well as diabetes, cancer and cardiovascular diseases, and created “shortened life tables” to estimate the number of years in general and with no remaining comorbidities for these populations at age 21.

Adults With HIV Data

The cohort (In Statistics, cohort is a group of people who have in common an event that took place in the same period - Wikipedia ) comprised 39.000 people living with HIV and about 390.000 controls. The average age was 41 years, almost all were men, 45% were white, 25% were black and 24% were Latino.

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Among the group with HIV, 70% were men who sex with men (MSM), about two thirds started ART during follow-up and about 30% had a CD4 count of at least 500 at the start of ART.

Overall, the researchers found a gap that decreases overall life expectancy, as people without HIV had a life expectancy of 65 years at 21 or 86 years based on the 2014-2016 data. A person living with HIV had a life expectancy of 56 years, or living up to 77 years in the same period, for an interval of nine years.

However, the same could not be said in the years free of comorbidity between the two groups. People without HIV can be expected to be 31 years old without comorbidities or who live to 52 without being diagnosed with a serious chronic comorbidity, while people with HIV can live up to 36 years until the same diagnosis.

Life Expectancy and Comorbidities

Marcus noted that, examining each comorbidity separately, there was a persistent gap in comorbidity-free life expectancy for liver, kidney and lung disease between the two groups, with a narrow gap in comorbidity-free life expectancy for diabetes, cancer and cardiovascular disease . THE normal life expectancy it became normal! Please define the normal word for me!

But the gap in overall life expectancy almost disappeared when the analysis was restricted to people living with HIV who started ART early and had high CD4 counts, although that was not the case for staying free of comorbidities. This group had an average of 13 years without comorbidities from 21 years old, against 29 years in the controls.

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Marcus said that comorbidity-free life expectancy improved early in the ART group for cancer and cardiovascular disease - but not for diabetes, kidney, lung or liver disease. "The difference in healthier years has narrowed for some, but not all comorbidities," said Marcus. "Greater attention is needed to prevent comorbidities in people with HIV".

Last updated on March 12, 2020! Yes it is, it is possible to live with HIV. However it is much better without THAT! Opens in another tab or window!

Disclosures

This study was supported by the National Institute of Allergy and Infectious Diseases.

Marcus publicized the support of Gilead Sciences.

Conference on retroviruses and opportunistic infections.

Research advances in relation to infectious treatment!

Source reference: Marcus J, et al “Increased overall life expectancy, but not years free of comorbidity for people with HIV” CROI 2020; Summary 151.

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