09 / 07 / 2010 - Research in São Paulo indicates that among HIV-positive people, HPV is more likely to turn into cancer




09/07/2010 – 18h30

The human papillomavirus (HPV), a virus that can cause cervical cancer in women or cancer in men's penis or anus, is more harmful among men with HIV, according to a study conducted at the Reference and Training Center on Sexually Transmitted Diseases and AIDS of the State of São Paulo (CRT).

According to research conducted by urologist Roberto José Carvalho da Silva, as a doctorate, the oncogenic HPV16 virus, that is, those most likely to be transformed into tumors, presented three times higher frequency of infection in the seropositive men analyzed.

About 144 men of 18 and 70 years old participated in the analysis, being 72 HIV positive and seronegative 72, partners of women with pathology associated with HPV.

Men who were on antiretroviral treatment and with viral load do HIV high (more than 1000 copies of the virus per cubic millimeter of blood) and T cell count CD4 low (less than 200 cells) showed higher acquisition rates and persistence of infection by HPV.

The research was guided by Professor Luisa Lina Villa and defended last March at the Faculty of Medicine of the University of São Paulo.

Research method - Penile cells were collected by smears for the diagnosis of HPV by PCR (Polymerase Chain Reaction). They were followed for 180 days to assess the persistence, acquisition and elimination of DNA from HPV.

More about HPV

O ACCUMULATED CONDILOMA is an injury to the genital region caused by HPV. The disease is also known as rooster crest, fig tree or crested horse.

Signs and Symptoms - O HPV It causes cauliflower-like warts of varying sizes on the genitals. It may also be related to the appearance of some cancers, especially in the cervix, but also in the penis or anus. However, not every case of infection with HPV will cause cancer.

Forms of Contagion - Infection by HPV it is very common. This virus is transmitted by direct contact with contaminated skin, even when it has no visible lesions. Transmission may also occur during oral sex. There is also the possibility of contamination through objects such as towels, underwear, toilets or bathtubs.

Prevention - There is no safe form of 100% prevention as the HPV it can even be transmitted through a towel or other object. It is estimated that the use of CONDOM can spread between 70% and 80% of transmissions, and its effectiveness is not greater because the virus may be housed elsewhere, not necessarily on the penis, but also on the skin of the pubic, perineum and anus.

New is the arrival, still in 2006, of the first vaccine capable of preventing infection by the two most common types of HPV, 6 and 11, responsible for 90% of warts, and also the two most dangerous types, 16 and 18, responsible for 70% of cervical cancer cases. Still under discussion the values ​​for dose (3 doses), for the Brazilian private market.

Most of the time men do not manifest the disease. Still, they are transmitters of the virus.

As for women, it is important for them to have a cervical cancer screening exam, known as a “Pap smear” or a preventive exam, regularly.

Treatment - The treatment of HPV It can be done by several methods: chemical, chemotherapeutic, immunotherapeutic and surgical. Most of them will destroy the diseased tissue.

Source: STD DEPARTMENT, AIDS and Viral Hepatitis of the Ministry of Health

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